Cirrhosis Progression Is Not Associated with Clinically Significant Alterations in Global Hemostasis Assessed by Thromboelastography
Rareș Crăciun,
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Alina Buliarcă,
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Daniela Matei
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et al.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(21), P. 6614 - 6614
Published: Nov. 4, 2024
(1)
Background:
Cirrhosis
is
associated
with
frequent
alterations
in
standard
coagulation
tests
that
do
not
adequately
reflect
hemostasis.
Thromboelastography
provides
a
global
assessment
of
and
evaluates
the
functional
status
clotting
factors,
fibrinogen,
platelets,
fibrinolysis.
The
study
aimed
to
assess
whether
liver
disease
severity
leads
progressive
thromboelastography-based
coagulation.
(2)
Methods:
Consecutive
patients
cirrhosis
abnormal
(at
least
one
International
Normalized
Ratio
>
2,
platelet
count
<
50
×
103/µL,
fibrinogen
200
mg/dL)
were
analyzed
using
native
thromboelastography.
(3)
Results:
A
total
106
included,
whom
69
(65.1%)
had
normal
While
significantly
worse
Child
C
group
(n
=
62,
58.5%)
than
staged
B,
no
significant
differences
existed
between
any
thromboelastography
variables.
Of
(47.1%)
an
only
two
(4%)
features
hypocoagulation,
while
26%
hypercoagulability
on
Patients
103/µL
lower
function
as
assessed
by
thromboelastography,
yet
eight
(20%)
met
criteria
for
transfusion.
transfusion
protocol
might
lead
94.6%
reduction
blood
product
indications
simulation
where
included
would
require
interventional
procedures.
(4)
Conclusion:
Standard
showed
poor
correlation
Based
severe,
decompensated
have
preserved
hemostasis
balance
despite
tests.
Therefore,
should
be
used
guide
administration
products
cirrhosis.
Language: Английский
Predicting and preventing bleeding in patients with cirrhosis undergoing procedures.
The American Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
1University
of
Virginia
Health
System,
Charlottesville,
Virginia,
USA
2Gastroenterology
Unit,
Chimomo
Department,
University
Modena
and
Reggio
Emilia
Azienda
Ospedaliero-Universitaria
di
Modena,
Italy.
aCorresponding
Author:
Nicolas
Intagliata,
MD,
MS,
Medical
Center,
Division
Gastroenterology
Hepatology,
PO
Box
800708,
VA
22908.
[email
protected].
434.242.2404
Language: Английский
Safety and outcomes of an on-demand transfusion strategy versus prophylactic transfusion of platelets in patients with liver cirrhosis and severe thrombocytopenia undergoing high-risk procedures: A post-hoc analysis of two randomized controlled trials
Journal of Clinical and Experimental Hepatology,
Journal Year:
2024,
Volume and Issue:
15(3), P. 102467 - 102467
Published: Nov. 30, 2024
Language: Английский