Chemistry & Biodiversity,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Biomarkers
for
the
prediction
of
diabetic
kidney
disease
are
still
unsatisfactory.
Although
D-amino
acids
have
been
shown
to
reflect
conditions,
their
efficacy
in
treating
(DKD)
has
not
demonstrated.
This
study
explored
potential
role
as
progression
markers
DKD,
an
aspect
addressed
previously.
We
performed
comprehensive
acid
measurements
and
collected
longitudinal
estimated
glomerular
filtration
rate
(eGFR)
data
135
patients.
defined
fast
decliners
(FDs)
patients
exhibiting
>10%
decline
from
baseline
eGFR
per
year
compared
levels
FDs
non-FDs.
Then,
we
verified
that
could
predict
independent
creatinine
levels.
In
with
disease,
D-serine,
D-alanine,
D-proline
were
only
detected
blood,
while
15
urine.
Using
supervised
orthogonal
partial
least
squares
analysis,
blood
D-serine
urine
identified
features
characterizing
disease.
Baseline
ratios
did
differ
between
FD
non-FD
groups;
however,
short-term
changes
differed.
emphasized
significance
a
prognostic
marker
previous
research.
Journal of Clinical Investigation,
Journal Year:
2023,
Volume and Issue:
133(4)
Published: Feb. 14, 2023
Kidney
disease
is
a
major
driver
of
mortality
among
patients
with
diabetes
and
diabetic
kidney
(DKD)
responsible
for
close
to
half
all
chronic
cases.
DKD
usually
develops
in
genetically
susceptible
individual
as
result
poor
metabolic
(glycemic)
control.
Molecular
genetic
studies
indicate
the
key
role
podocytes
endothelial
cells
driving
albuminuria
early
diabetes.
Proximal
tubule
changes
show
strong
association
glomerular
filtration
rate.
Hyperglycemia
represents
cellular
stress
by
altering
metabolism
imposing
an
excess
workload
requiring
energy
oxygen
proximal
cells.
Changes
induce
adaptive
hypertrophy
reorganization
actin
cytoskeleton.
Later,
mitochondrial
defects
contribute
increased
oxidative
activation
inflammatory
pathways,
causing
progressive
function
decline
fibrosis.
Blockade
renin-angiotensin
system
or
sodium-glucose
cotransporter
associated
protection
slowing
decline.
Newly
identified
molecular
pathways
could
provide
basis
development
much-needed
novel
therapeutics.
Journal of Diabetes Investigation,
Journal Year:
2023,
Volume and Issue:
14(4), P. 503 - 515
Published: Jan. 14, 2023
Abstract
Type
2
diabetes
results
from
a
complex
interaction
between
genetic
and
environmental
factors.
Precision
medicine
for
type
using
data
is
expected
to
predict
the
risk
of
developing
complications
effects
medications
life‐style
intervention
more
accurately
individuals.
Genome‐wide
association
studies
(GWAS)
have
been
conducted
in
European
Asian
populations
new
loci
identified
that
modulate
diabetes.
Novel
were
discovered
by
GWAS
diabetic
with
increasing
sample
sizes.
Large‐scale
genome‐wide
analysis
polygenic
scores
biobank
information
making
it
possible
development
In
ADVANCE
clinical
trial
diabetes,
multi‐polygenic
score
was
useful
their
response
treatment.
Proteomics
metabolomics
revealed
associations
inflammatory
signals
amino
acid
synthesis.
Using
multi‐omics
analysis,
comprehensive
molecular
mechanisms
elucidated
guide
targeted
therapy
complications.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
161, P. 114465 - 114465
Published: March 3, 2023
Lipotoxicity
is
the
dysregulation
of
lipid
environment
and/or
intracellular
composition
that
leads
to
accumulation
harmful
lipids
and
ultimately
organelle
dysfunction,
abnormal
activation
signaling
pathways,
chronic
inflammation
cell
death.
It
plays
an
important
role
in
development
acute
kidney
injury
disease,
including
diabetic
nephropathy,
obesity-related
glomerulopathy,
age-related
polycystic
like.
However,
mechanisms
overload
remain
poorly
understood.
Herein,
we
discuss
two
pivotal
aspects
lipotoxic
injury.
First,
analyzed
mechanism
kidney.
Accumulating
data
indicate
different
diseases
are
inconsistent.
Second,
summarize
multiple
by
which
species
affect
behavior,
oxidative
stress,
endoplasmic
reticulum
mitochondrial
dysregulated
autophagy,
inflammation,
highlighting
central
stress.
Blocking
molecular
pathways
damage
may
be
potential
therapeutic
targets
for
antioxidant
drugs
play
a
treatment
disease
future.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10222 - 10222
Published: Sept. 23, 2024
Diabetic
kidney
disease
(DKD)
is
a
major
complication
of
diabetes
mellitus
(DM),
affecting
over
one-third
type
1
and
nearly
half
2
patients.
As
the
leading
cause
end-stage
renal
(ESRD)
globally,
DKD
develops
through
complex
interplay
chronic
hyperglycemia,
oxidative
stress,
inflammation.
Early
detection
crucial,
with
diagnosis
based
on
persistent
albuminuria
reduced
estimated
glomerular
filtration
rate
(eGFR).
Treatment
strategies
emphasize
comprehensive
management,
including
glycemic
control,
blood
pressure
regulation,
use
nephroprotective
agents
such
as
angiotensin-converting
enzyme
(ACE)
inhibitors,
angiotensin
II
receptor
blockers
(ARBs),
sodium-glucose
cotransporter-2
(SGLT2)
glucagon-like
peptide-1
(GLP-1)
agonists.
Ongoing
research
explores
novel
therapies
targeting
molecular
pathways
non-coding
RNAs.
Preventive
measures
focus
rigorous
control
hyperglycemia
hypertension,
aiming
to
mitigate
progression.
Despite
therapeutic
advances,
remains
ESRD,
highlighting
need
for
continued
identify
new
biomarkers
innovative
treatments.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 4, 2024
Abstract
The
mitochondrial
electron
transport
chain
(ETC)
is
a
highly
adaptive
process
to
meet
metabolic
demands
of
the
cell,
and
its
dysregulation
has
been
associated
with
diverse
clinical
pathologies.
However,
role
nature
impaired
ETC
in
kidney
diseases
remains
poorly
understood.
Here,
we
generate
diabetic
mice
podocyte-specific
overexpression
Ndufs4,
an
accessory
subunit
complex
I,
as
model
investigate
integrity
disease
(DKD).
We
find
that
conditional
male
genetic
Ndufs4
exhibit
significant
improvements
cristae
morphology,
dynamics,
albuminuria.
By
coupling
proximity
labeling
super-resolution
imaging,
also
identify
shaping
protein
STOML2
linking
NDUFS4
improved
morphology.
Together,
provide
evidence
on
central
regulator
remodeling
function
podocytes.
propose
targeting
represents
promising
approach
slow
progression
DKD.
Phytomedicine,
Journal Year:
2024,
Volume and Issue:
130, P. 155705 - 155705
Published: May 3, 2024
Senolytic
combination
of
dasatinib
and
quercetin
(DQ)
is
the
most
studied
senolytics
drugs
used
to
treat
various
age-related
diseases.
However,
its
protective
activity
against
diabetic
kidney
disease
(DKD)
underlying
mechanisms
are
uncertain.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(11)
Published: June 1, 2024
Abstract
Diabetic
kidney
disease
(DKD)
is
a
leading
cause
of
end
stage
renal
with
unmet
clinical
demands
for
treatment.
Lipids
are
essential
cell
survival;
however,
cells
have
limited
capability
to
metabolize
overloaded
lipids.
Dyslipidaemia
common
in
DKD
patients
and
ectopic
lipid
accumulation
associated
progression.
Unveiling
the
molecular
mechanism
involved
regulation
crucial
exploring
potential
therapeutic
targets.
In
this
review,
we
focused
on
underlying
cholesterol,
oxysterol
fatty
acid
metabolism
disorder
context
DKD.
Specific
regulators
different
compartment
TREM2
macrophages,
lipid‐related
macrophages
DKD,
were
discussed.
The
role
sodium‐glucose
transporter
2
inhibitors
improving
was
summarized.
