Micro/nanoplastics in aquaponic systems: sources, features and and their effects on the immune system of fish

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118158 - 118158

Published: Jan. 1, 2025

Language: Английский

---

Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109109 - 109109

Published: Nov. 1, 2024

Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.

Language: Английский

---

Toxicological effects and mechanisms of renal injury induced by inhalation exposure to airborne nanoplastics

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137393 - 137393

Published: Jan. 30, 2025

Language: Английский

---

Effects of microplastics on the immune system: How much should we worry?

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

---

Postbiotic Sodium Butyrate Mitigates Hypertension and Kidney Dysfunction in Juvenile Rats Exposed to Microplastics

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 276 - 276

Published: Feb. 26, 2025

Plastic production has led to widespread microplastic (MP) pollution, with children more vulnerable MPs than adults. However, the mechanisms linking MP exposure hypertension and kidney disease in remain unclear. This study explored whether sodium butyrate, a short-chain fatty acid (SCFA) antioxidant anti-inflammatory properties, could mitigate MP-induced damage juvenile rats. Male Sprague-Dawley rats (3 weeks old) were randomly assigned four groups (n = 8/group): control, low-dose (1 mg/L), high-dose (10 butyrate (400 mg/kg/day). Rats euthanized at 12 weeks. High-dose impaired function increased blood pressure, which alleviated by through reduced oxidative stress, modulation of gut microbiota, plasma butyric levels, enhanced renal SCFA-sensing G protein-coupled receptor 43 expression. Sodium holds potential for mitigating reducing modulating elevating levels.

Language: Английский

---

Identification of microplastics in the aquatic environment, or in the presence of algae Chlorella sp., by comparison of biophotonic methods

Polymer Testing, Journal Year: 2025, Volume and Issue: unknown, P. 108749 - 108749

Published: Feb. 1, 2025

Language: Английский

---

Polystyrene microplastics induce nephrotoxicity through DDIT4-mediated autophagy and apoptosis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118066 - 118066

Published: March 23, 2025

Language: Английский

---

Mechanism of Nano‐Microplastics Exposure‐Induced Myocardial Fibrosis: DKK3‐Mediated Mitophagy Dysfunction and Pyroptosis

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 22, 2025

ABSTRACT Nano‐microplastics (NMPs), as environmental pollutants, are widely present in nature and pose potential threats to biological health. This study aims investigate the mechanisms by which NMPs inhibit mitophagy through suppression of dickkopf‐related protein 3 (DKK3) expression, leading NOD‐like receptor family, pyrin domain containing (NLRP3) inflammasome‐mediated cardiomyocyte pyroptosis promoting myocardial fibrosis. Healthy adult male C57BL/6 mice were administered NMP solution via gavage, their cardiac function was monitored. The results showed that exposure significantly reduced left ventricular ejection fraction (LVEF) fractional shortening (LVFS) increased extent Transcriptome sequencing identified 14 differentially expressed genes (DEGs), including MYL7. Using random forest algorithm functional enrichment analysis, DKK3 a key gene. In Vitro experiments further confirmed downregulate thereby inhibiting pyroptosis. elucidates molecular induce fibrosis provides new theoretical bases targets for diagnosis treatment heart diseases.

Language: Английский

---

Can plastics in urine serve as a noninvasive marker of systemic accumulation?

Kidney International, Journal Year: 2024, Volume and Issue: 106(4), P. 757 - 757

Published: Sept. 18, 2024

Language: Английский

---

Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1457 - 1457

Published: Nov. 27, 2024

Global pollution stems from the degradation of plastic waste, leading to generation microplastics (MPs). While environmental pollutants increase risk developing hypertension and kidney disease, effects MP exposure on these conditions in children remain unclear. Resveratrol, a phenolic compound known for its antihypertensive renoprotective properties, has gained attention as potential nutraceutical. This study investigates resveratrol disease induced by juvenile rat model. Three-week-old male Sprague–-Dawley (SD) rats were randomly allocated into four groups (n = 8 per group): control group, low-dose group (1 mg/L), high-dose (10 receiving (50 mg/L). By 9 weeks age, resulted elevated blood pressure increased creatinine levels, both which mitigated treatment. The damage linked oxidative stress, effectively prevented. Additionally, resveratrol’s protective against associated with acetic acid reduced renal expression Olfr78, decreased various components renin-angiotensin system (RAS). Low- exposure, well treatment, differentially influence gut microbiota composition. Our findings suggest that targeting microbiota, RAS through holds therapeutic preventing exposure. However, further research is needed translate results clinical applications.

Language: Английский

---