Prof. Dr. Giovanni De Toni—Editorial for the Commemoration of a Pediatric Luminary

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3198 - 3198

Published: March 30, 2025

Living in Liguria, acknowledging that the sea may be a metaphor for human condition is not difficult [...]

Language: Английский

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Fibroblast growth factor 23 as a risk factor for incident diabetes

Current Opinion in Nephrology & Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Purpose of review Diabetes is a major global health concern, affecting millions and increasing morbidity mortality. Recent research highlights fibroblast growth factor 23 (FGF23) as potential contributor to type 2 diabetes its cardiovascular complications. This explores the role FGF23 in metabolic dysfunction discusses possible therapeutic interventions. findings Deregulated linked insulin resistance, pancreatic β-cell dysfunction, systemic inflammation. Studies suggest influences glucose metabolism via signaling, oxidative stress, Epidemiological data indicate that elevated levels are associated with an increased risk posttransplant diabetes, independent traditional factors. Higher have also been patients even without chronic kidney disease. Summary emerging key cardiovascular-kidney-metabolic syndrome, connecting While studies consistent associations, causal mechanisms remain unclear. No therapies specifically target lower risk, but receptor 4 (FGFR4) inhibitors show promise. Future should examine individuals normal function explore whether modifying could reduce risk.

Language: Английский

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Fibroblast growth factor (FGF) 23 and FGF receptor 4 induced cardiac mitochondrial dysfunction as a new target in CKD?

Kidney International, Journal Year: 2025, Volume and Issue: 107(5), P. 782 - 784

Published: April 18, 2025

Language: Английский

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