Persistent Exertional Intolerance After COVID-19

CHEST Journal, Journal Year: 2021, Volume and Issue: 161(1), P. 54 - 63

Published: Aug. 11, 2021

Language: Английский

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Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 5, 2022

About 10% of people infected by severe acute respiratory syndrome coronavirus 2 experience post COVID-19 disease. We analysed data from 968 adult patients (5350 person-months) with a confirmed infection enroled in the ComPaRe long COVID cohort, disease prevalent prospective e-cohort such France. Day-by-day prevalence symptoms was determined patients' responses to Long Symptom Tool, validated self-reported questionnaire assessing 53 symptoms. Among symptomatic after months, 85% still reported one year their symptom onset. Evolution showed decreasing over time for 27/53 (e.g., loss taste/smell); stable 18/53 dyspnoea), and an increasing 8/53 paraesthesia). The impact on lives began 6 months Our results are importance understand natural history

Language: Английский

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Neurological manifestations of long-COVID syndrome: a narrative review

Therapeutic Advances in Chronic Disease, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 1, 2022

Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, is conceptualized as multi-organ disorder with wide spectrum clinical manifestations that may be indicative underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or disease. Involvement the central peripheral nervous system noted in more than one-third patients antecedent severe acute respiratory syndrome 2 (SARS-CoV-2) infection, while an approximately threefold higher incidence recorded observational studies including patient-reported data. The most frequent encompass fatigue; 'brain fog'; headache; cognitive impairment; sleep, mood, smell, taste disorders; myalgias; sensorimotor deficits; and dysautonomia. Although limited exists to date on pathophysiological mechanisms implicated manifestation 'long-COVID', neuroinflammatory oxidative stress processes thought prevail propagating sequelae. In this narrative review, we sought present comprehensive overview our current understanding features, risk factors, Moreover, propose diagnostic therapeutic algorithms aid prompt recognition management causes persist beyond resolution COVID-19. Furthermore, causal treatments currently unavailable, approaches symptom-oriented symptoms. addition, emphasize collaborative research initiatives urgently needed expedite development preventive strategies

Language: Английский

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Post-acute COVID-19 syndrome

European Respiratory Review, Journal Year: 2022, Volume and Issue: 31(163), P. 210185 - 210185

Published: March 9, 2022

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the disease 2019 (COVID-19) pandemic that has resulted in millions of deaths and a major strain on health systems worldwide. Medical treatments COVID-19 (anticoagulants, corticosteroids, anti-inflammatory drugs, oxygenation therapy ventilation) vaccination have improved patient outcomes. The majority patients will recover spontaneously or after acute-phase management, but clinicians are now faced long-term complications including large variety symptoms, defined as “post-acute syndrome”. Most studies focused hospitalised COVID-19, not restricted to these exists outpatients. Given diversity symptoms high prevalence persistent management requires multidisciplinary team approach, which result consumption amounts resources coming months. In this review, we discuss presentation, prevalence, pathophysiology evolution other organ-related injuries associated post-acute syndrome.

Language: Английский

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Post-COVID syndrome. A case series and comprehensive review

Autoimmunity Reviews, Journal Year: 2021, Volume and Issue: 20(11), P. 102947 - 102947

Published: Sept. 10, 2021

Language: Английский

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One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China

JAMA Neurology, Journal Year: 2022, Volume and Issue: 79(5), P. 509 - 509

Published: March 8, 2022

Importance

Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in research and health policy.

Objective

To investigate 1-year trajectory cognitive changes older survivors.

Design, Setting, Participants

This cohort study recruited 3233 survivors 60 years who were discharged from 3 COVID-19–designated hospitals Wuhan, China, February 10 April 10, 2020. Their uninfected spouses (N = 466) as a control population. Participants with preinfection impairment, concomitant neurological disorder, or family history dementia excluded, well those severe cardiac, hepatic, kidney disease any kind tumor. Follow-up monitoring functioning decline took place at 6 12 months. A total 1438 438 individuals included final follow-up. was categorized nonsevere following American Thoracic Society guidelines.

Main Outcomes Measures

The main outcome change 1 year after patient discharge. Cognitive during first second 6-month follow-up periods assessed using Informant Questionnaire Decline Elderly Telephone Interview Status-40, respectively. Based observed 2 periods, trajectories classified into 4 categories: stable cognition, early-onset decline, late-onset progressive decline. Multinomial conditional logistical regression models used identify factors associated risk

Results

Among 1317 screened, participants treated for (691 male [48.05%] 747 female [51.95%]; median [IQR] age, 69 [66-74] years) (222 [50.68%] 216 [49.32%]; 67 completed 12-month incidence impairment months discharge 12.45%. Individuals cases had lower Status-40 scores than (median [IQR]: severe, 22.50 [16.00-28.00]; nonsevere, 30.00 [26.00-33.00]; control, 31.00 [26.00-33.00]). Severe higher (odds ratio [OR], 4.87; 95% CI, 3.30-7.20), (OR, 7.58; 3.58-16.03), 19.00; 9.14-39.51), while 1.71; 1.30-2.27) when adjusting sex, education level, body mass index, comorbidities.

Conclusions Relevance

In this study, survival an increase longitudinal highlighting importance measures deal challenge.

Language: Английский

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Long COVID following Mild SARS-CoV-2 Infection: Characteristic T Cell Alterations and Response to Antihistamines

Journal of Investigative Medicine, Journal Year: 2021, Volume and Issue: 70(1), P. 61 - 67

Published: Oct. 5, 2021

Long COVID is characterized by the emergence of multiple debilitating symptoms following SARS-CoV-2 infection. Its etiology unclear and it often follows a mild acute illness. Anecdotal reports gradual clinical responses to histamine receptor antagonists (HRAs) suggest histamine-dependent mechanism that distinct from anaphylaxis, possibly mediated T cells, which are also regulated histamine. cell perturbations have been previously reported in post-viral syndromes, but landscape patients who recovered COVID-19 its relationship both long any symptomatic response HRA remain underexplored. We addressed these questions an observational study 65 individuals had COVID-19. Participants were surveyed between 87 408 days after onset symptoms; none required hospitalization, 16 uneventfully, 49 developed COVID. Symptoms quantified using structured questionnaire subsets enumerated standard diagnostic assay. Patients with long-COVID reduced CD4+ CD8+ effector memory (EM) numbers increased PD-1 (programmed death protein 1) expression on central (CM) whereas asymptomatic participants EM cells only CD28 CM cells. 72% received improvement, although profiling did not clearly distinguish those responded HRA. This demonstrates persist for several months associated symptoms.

Language: Английский

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Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: June 30, 2022

The duration and severity of COVID-19 are related to age, comorbidities, cytokine synthesis. This study evaluated the impact these factors on patients with clinical presentations in a Brazilian cohort. A total 317 diagnosed were included; cases distributed according status as severe (n=91), moderate (n=56) mild (n=170). Of patients, 92 had acute at sample collection, 90 already recovered from without sequelae, 135 sequelae (long COVID syndrome). In group, form higher IL-6 levels (p=0.0260). post-COVID-19 there was no significant difference between groups different conditions. younger TNF-α, comorbidities IL-4 IL-2 (p<0.05). contrast, over age 60 IL-6. subjects long IL-17 (p<0.05), IL-10, IL- 4 Our results suggest that advanced elevated serum associated good markers differentiate cases. Furthermore, high low IL-10 appear constitute profile COVID-19, potential targets for treatment prevention strategies.

Language: Английский

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Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID‐19

Clinical & Experimental Allergy, Journal Year: 2021, Volume and Issue: 51(9), P. 1107 - 1120

Published: Aug. 5, 2021

The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with and potential risk factors.

Language: Английский

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Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 22, 2023

COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, cognitive dysfunction that last for months impact everyday functioning, is referred to Long COVID under the general category post-acute sequelae SARS-CoV-2 infection (PASC). PASC highly heterogenous may be associated multisystem tissue damage/dysfunction including acute encephalitis, cardiopulmonary syndromes, fibrosis, hepatobiliary damages, gastrointestinal dysregulation, myocardial infarction, neuromuscular neuropsychiatric disorders, pulmonary damage, renal failure, stroke, vascular endothelial dysregulation. A better understanding pathophysiologic mechanisms underlying essential guide prevention treatment. This review addresses potential hypotheses connect long-term health consequences. Comparisons between other virus-initiated chronic syndromes myalgic encephalomyelitis/chronic fatigue syndrome postural orthostatic tachycardia will addressed. Aligning identifying potentially regulated common underlining pathways necessary true nature PASC. The discussed contributors include from injury one or more organs, reservoirs replicating virus its remnants in several tissues, re-activation latent pathogens Epstein-Barr herpes viruses COVID-19 immune-dysregulated environment, interactions host microbiome/virome communities, clotting/coagulation dysfunctional brainstem/vagus nerve signaling, dysautonomia autonomic dysfunction, ongoing activity primed immune cells, autoimmunity due molecular mimicry pathogen proteins. individualized suggests different therapeutic approaches required best manage specific patients.

Language: Английский

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