Journal of Neurology, Journal Year: 2024, Volume and Issue: 272(1)
Published: Dec. 21, 2024
Language: Английский
Gait & Posture, Journal Year: 2025, Volume and Issue: 119, P. 171 - 177
Published: March 20, 2025
Greater gait variability is associated with falls in aging and multiple sclerosis. However, whether older adults MS (OAMS), show higher relative to healthy (HOA), under single dual-task walking conditions, has not been reported. Furthermore, it unclear practice may improve both groups. Is OAMS HOA, particularly DTW compared STW? does result decreased groups, notably We examined the effect of within-session on during (STW) dual (DTW) task conditions. (n = 97, mean±SD age: 65 ± 5 years, 66 females) HOA 113, 68 7 73 were recruited. Practice effects evaluated over three repeated counterbalanced STW trials. Gait measures included Coefficient Variation (CV) stride velocity, length, swing time. demonstrated variability, all measures, (P < 0.001). was STW, 0.05). resulted 0.01) HOA. temporal as measured by time CV, particular In conclusion, exhibited greater than yet groups decreases spatial after practice, DTW, which turn reduce fall risk.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113641 - 113641
Published: March 1, 2025
Language: Английский
Citations
0
Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
Objective To compare clinical and radiological outcomes among relapsing multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT), alemtuzumab (ATZ), ocrelizumab (OCR). Methods From a London (UK) hospital‐based observational cohort, modeled data were obtained from 621 relapsing–remitting patients, who AHSCT (n = 103), ATZ 204), OCR 314), followed up for 43, 32 median months, respectively. The annualized relapse rate, new magnetic resonance imaging (MRI) lesions, disability progression on Expanded Disability Status Scale assessed. Results showed superior efficacy compared OCR. After 5‐year follow up, the mean rate (0.026 vs 0.087; p < 0.001), risk of relapses (HR 0.29, 95% CI 0.13–0.63; 0.002), MRI activity 0.33, 0.15–0.72; 0.006) significantly lower in versus group. Compared OCR, after 3‐year follow‐up (0.028 0.073; 0.02) trend to reduced 0.45, 0.18–1.14; 0.09), but similar low rates (6%) 0.86, 0.28–2.67; 0.80). In addition, there was AHSCT, both 1.19, 0.71–2.00; 0.50) 1.08, 0.57–2.04; 0.82) groups. Interpretation by greater prevention suppressed more profoundly than ATZ, similarly albeit shorter up. accumulating Studies larger sample sizes longer may enable confirmation these findings or detection any additional differential effects. ANN NEUROL 2025
Language: Английский
Citations
0
Sclerosis, Journal Year: 2025, Volume and Issue: 3(2), P. 15 - 15
Published: April 29, 2025
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system affecting over 2.8 million people around world. Artificial intelligence (AI) becoming increasingly utilised in many areas, including patient care for MS. AI revolutionising diagnosis and treatment MS by enhancing accuracy efficiency both processes. algorithms, particularly those based on machine learning, are being used to analyse medical imaging data, such as MRI scans, detect early signs MS, monitor progression assess response with greater precision. can help identify subtle changes brain spinal cord that may be missed human clinicians, leading earlier more personalised plans. Additionally, employed predict outcomes, which could allow clinicians tailor therapies individual patients their unique characteristics. In drug development, accelerating identification potential therapeutic targets optimisation clinical trial designs, potentially faster development new treatments also playing a critical role fundamental research promoting efficient analysis vast amounts single-cell data. Through these advancements, improve overall management offering timely interventions better outcomes. this review, we discuss topics whether influence diagnosis, change future field.
Language: Английский
Citations
0
Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(6)
Published: May 18, 2025
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0312421 - e0312421
Published: Dec. 5, 2024
Background Multiple sclerosis (MS) is a central nervous system disorder marked by progressive neurological impairments. Magnetic resonance imaging (MRI) parameters are key paraclinical measures that play crucial role in the diagnosis, prognosis, and monitoring of MS-related disability. This study aims to analyze summarize existing literature on correlation between MRI disability people with MS (pwMS). Methods The PubMed/MEDLINE, Embase, Scopus, Web Science databases were searched from inception July 19, 2024, meta-analysis was carried out using R software version 4.4.0 random effects model used determine pooled coefficient, its 95% confidence interval (CI), measurements scales. Results Among 5741 studies, 383 studies 39707 pwMS included. demonstrated Expanded Disability Status Scale (EDSS) had significant correlations cervical cord volume (r = -0.51, CI: -0.62 -0.38, I 2 0%, p -heterogeneity 0.86, -value<0.01), cortical lesion 0.45, 0.36 0.53, 68%, -heterogeneity<0.01, brain -0.40, -0.47 -0.33, 41%, 0.05, -value<0.05), grey matter (GMV) -0.36, -0.49 -0.21, respectively. Conclusion offers evidence suggesting volume, GMV, spinal may constitute reliable indicators for assessing pwMS.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 884 - 884
Published: Jan. 21, 2025
In multiple sclerosis (MS), there is significant evidence indicating that both progression independent of relapse activity (PIRA) and relapse-related worsening events contribute to the accumulation progressive disability from onset disease throughout its course. Understanding compartmentalized pathophysiology MS would enhance comprehension mechanisms, overcoming traditional distinction in phenotypes. Smoldering thought be maintained by a continuous interaction between parenchymal chronic processes neuroinflammation neurodegeneration intrathecal compartment. This review provides comprehensive up-to-date overview neuropathological immunological related mechanisms underlying PIRA phenomena MS, with focus on studies investigating impact currently available therapies these complex mechanisms.
Language: Английский
Citations
0
BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 6, 2025
Previous studies have examined the various outcomes of expressive writing intervention in different populations. The purpose this study was to evaluate effect on sexual self-concept men with multiple sclerosis. This parallel randomized controlled clinical trial conducted 70 attending an MS clinic Tehran 2022. participants were randomly assigned and control groups. For two weeks, group disclosed their emotions expressed feelings twice a week. Sexual evaluated using Multidimensional Self-Concept Questionnaire three occasions, before, after, 4-week follow-up. data ware analyzed SPSS software version 22 (IBM Corp., Armonk, N.Y., USA). analysis employed Chi-squared test, Fisher's exact independent t-test, repeated measured ANOVA. A p-value < 0.05 considered be statistically significant. mean age 38.6 ± 6.85 years, while it 38.94 6.07 years. There no significant differences between groups, terms these characteristics. According results, dimensions SSC did not change over time assessments, except for problem self-blame (p = 0.011) fear/apprehension 0.042) group, motivation 0.002). On other hand, before intervention, significantly higher compared 0.046). Our findings support general effectiveness 2-week dimensions. However, further research is needed better understand effects sclerosis, controlling limitations our study. present has been registered Iranian Registry Clinical Trials (IRCT) at https://irct.behdasht.gov.ir/trial/59664 November 17, 2021, code IRCT20211028052892N1.
Language: Английский
Citations
0
Internal Medicine Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
The global prevalence of multiple sclerosis (MS) is increasing, and early diagnosis treatment essential in mitigating disability. While recent therapeutic advancements have significantly reduced relapse rates, the progressive degenerative aspects MS continue to pose major challenges. This year updates McDonald diagnostic criteria aim enhance sensitivity facilitate earlier use disease-modifying therapies asymptomatic patients. Additionally, novel biomarkers will gain ground clinical practice offer new approaches optimising care. Following widespread cell depleting immunosuppressive agents, innovative directions such as chimeric antigen receptor T-cell therapy Epstein-Barr virus (EBV) vaccination represent promising management MS. perspective provides a comprehensive overview disease while highlighting important shaping future field.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3889 - 3889
Published: April 20, 2025
Multiple sclerosis (MS) is a chronic, immune-mediated disease that affects young adults, leading to neurological disability. Regardless of the studies and research involved in developing an efficient disease-modifying therapy (DMT), relapsing-remitting multiple (RRMS) will transition progressive phenotype. The moment from RRMS secondary (SPMS) difficult predict, diagnosis based on accumulation disabilities evolution disease. Research microRNAs' (miRNAs) role MS began early 2000s, with miR-155 frequently cited for its link blood-brain barrier dysfunction neurodegeneration, making it biomarker SPMS. purpose this review reveal importance finding molecular field be able identify phase so patients can receive high-efficacy treatments cease clinical progression.
Language: Английский
Citations
0