Population Behavior Changes Underlying Phasic Shifts of SARS-CoV-2 Exposure Settings Across 3 Omicron Epidemic Waves in Hong Kong: Prospective Cohort Study (Preprint) DOI
Chin Pok Chan, Shui Shan Lee, Tsz Ho Kwan

et al.

Published: Aug. 2, 2023

BACKGROUND Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. OBJECTIVE This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. METHODS From March June 2022, invitation letters were posted 41,132 randomly selected residential addresses for recruitment households into a prospective population cohort. Through web-based monthly surveys coupled email reminders, representative from each enrolled household self-reported incidents infections, COVID-19 vaccination uptake, their activity pattern workplace, daily preceding month. As proxy risk, reported trend setting differentiated trajectories based on latent class growth analyses. associations overall wave (wave 1: February-April; 2: May-September; 3: October-December) 2022 evaluated using Cox proportional hazards models Kaplan-Meier analysis. RESULTS In total, 33,501 responses observation period February-December collected 5321 individuals, 41.7% (2221/5321) being male median age 46 (IQR 34-57) years. Against an expanding coverage 81.9% 95.9% 2 doses 20% 77.7% doses, cumulative incidence escalated <0.2% 25.3%, 32.4%, 43.8% end 1, 2, 3, respectively. Throughout 52.2% (647/1240) participants had worked regularly on-site, 28.7% (356/1240) remotely, 19.1% (237/1240) showed assorted pattern. For settings, 4 5 identified, respectively, 11.5% (142/1240) 14.6% (181/1240) gauged high risk. Compared remote working, working on-site (adjusted hazard ratio [aHR] 1.47, 95% CI 1.19-1.80) living larger (aHR 1.12, 1.06-1.18) associated higher 1. Those highest 1.46, 1.07-2.00) second 1.52, 1.18-1.97) also at increased relative lowest trajectory. CONCLUSIONS infection-naive population, transmission predominantly initiated accelerated household, perpetuated environments, as stringent restrictions scaled down. These patterns highlight phasic shift which is important informing effective calibration targeted measures alternative lockdown.

Language: Английский

Immune escape of SARS-CoV-2 variants to therapeutic monoclonal antibodies: a system review and meta-analysis DOI Creative Commons

Huichun Shi,

Jiajia Sun,

Yigang Zeng

et al.

Virology Journal, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 15, 2023

Abstract Background Omicron's high transmissibility and variability present new difficulties for COVID-19 vaccination prevention therapy. In this article, we analyzed the sensitivity of vaccine-induced antibodies as well effect booster vaccinations against Omicron sublineages. Methods We looked Randomized Controlled Trials cohort studies that reported vaccines sublineages up to 28 July 2022 through PubMed, Cochrane Library, EMBASE, Web Science. Quantitative synthesis was carried out using Stata 16.0 RevMa5.3, then serum NT50 antibody neutralize were assessed before after vaccination. This study registered with PROSPERO number CRD42022350477. Results meta-analysis included 2138 patients from 20 studies, showed a significant difference compared 2 dosage: BA.1/BA.1.1 (SMD = 0.80, 95% CI: 0.75–0.85, P 0.00), BA.2/BA.2.12.1 0.77, 0.69–0.85, BA.3 0.91, 0.83–1.0, BA.4/5 0.60–0.94, 0.00). The vaccines-induced decreased by at least 5-folds vaccination, particularly in case which had most notable decline vaccine effectiveness. Conclusion After neutralization ability increased, but susceptibility control virus, may be clue future prevention.

Language: Английский

Citations

1
Mutational basis of serum cross-neutralization profiles elicited by infection or vaccination with SARS-CoV-2 variants DOI Open Access
Kshitij Wagh, Xiaoying Shen, James Theiler

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

SUMMARY A series of SARS-CoV-2 variants emerged during the pandemic under selection for neutralization resistance. Convalescent and vaccinated sera show consistently different cross-neutralization profiles depending on infecting or vaccine variants. To understand basis this heterogeneity, we modeled serum titers 165 after infection vaccination with historically prominent lineages tested against 18 variant pseudoviruses. Cross-neutralization were well captured by models incorporating autologous neutralizing combinations specific shared differing mutations between infecting/vaccine Infecting/vaccine variant-specific identified that significantly impacted quantified their relative contributions. Unified explained across all provided accurate predictions holdout data comprising untested as variants, test Finally, comparative modeling 2-dose versus 3-dose mRNA-1273 revealed third dose overcame key resistance to improve breadth. HIGHLIGHTS Modeled using at sites Identified impact Accurately predicted convalescent/vaccine Showed overcomes

Language: Английский

Citations

0
Durability of immune response against omicron BA.2 and BA.4/5 and T cell responses after boosting with mRNA and adenoviral vector-based vaccines following heterologous CoronaVac/ChAdOx-1nCov-19 vaccination DOI Creative Commons
Nungruthai Suntronwong, Sitthichai Kanokudom,

Thaksaporn Thatsanathorn

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(3)

Published: Nov. 28, 2023

Heterologous vaccination with inactivated vaccine followed by adenoviral vector-based has shown superiority in enhancing immune response compared to homologous primary series. However, data comparing immunity decline after a third booster following heterologous CoronaVac/ChAdOx-1nCov-19 been limited. Here, we assessed neutralizing activity against omicron variant and T cell at 3 months monitoring 96 individuals who received ChAdOx-1nCov-19, BNT162b2, or mRNA-1273 as dose CoronaVac/ChAdOx-1nCov-19. Comparing the antibody levels 1 month(s) booster, results showed persistence of anti-RBD IgG all regimens, level waning slower ChAdOx-1nCov-19 boosted group (geometric mean ratio (GMR): 0.64 (95%CI: 0.59–0.70)) BNT162b2 (0.34 (95%CI:0.31–0.38)) groups (0.32 0.29–0.36)). Neutralizing BA.2 BA.4/5 dropped 1.2 1.5-fold but remained detectable, highest observed group, groups, respectively. Furthermore, number reactivity decreased while it increased 3-month post-boost month. Data on durability could help comprehensively optimize strategy.

Language: Английский

Citations

0
Population Behavior Changes Underlying Phasic Shifts of SARS-CoV-2 Exposure Settings Across 3 Omicron Epidemic Waves in Hong Kong: Prospective Cohort Study (Preprint) DOI
Chin Pok Chan, Shui Shan Lee, Tsz Ho Kwan

et al.

Published: Aug. 2, 2023

BACKGROUND Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. OBJECTIVE This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. METHODS From March June 2022, invitation letters were posted 41,132 randomly selected residential addresses for recruitment households into a prospective population cohort. Through web-based monthly surveys coupled email reminders, representative from each enrolled household self-reported incidents infections, COVID-19 vaccination uptake, their activity pattern workplace, daily preceding month. As proxy risk, reported trend setting differentiated trajectories based on latent class growth analyses. associations overall wave (wave 1: February-April; 2: May-September; 3: October-December) 2022 evaluated using Cox proportional hazards models Kaplan-Meier analysis. RESULTS In total, 33,501 responses observation period February-December collected 5321 individuals, 41.7% (2221/5321) being male median age 46 (IQR 34-57) years. Against an expanding coverage 81.9% 95.9% 2 doses 20% 77.7% doses, cumulative incidence escalated <0.2% 25.3%, 32.4%, 43.8% end 1, 2, 3, respectively. Throughout 52.2% (647/1240) participants had worked regularly on-site, 28.7% (356/1240) remotely, 19.1% (237/1240) showed assorted pattern. For settings, 4 5 identified, respectively, 11.5% (142/1240) 14.6% (181/1240) gauged high risk. Compared remote working, working on-site (adjusted hazard ratio [aHR] 1.47, 95% CI 1.19-1.80) living larger (aHR 1.12, 1.06-1.18) associated higher 1. Those highest 1.46, 1.07-2.00) second 1.52, 1.18-1.97) also at increased relative lowest trajectory. CONCLUSIONS infection-naive population, transmission predominantly initiated accelerated household, perpetuated environments, as stringent restrictions scaled down. These patterns highlight phasic shift which is important informing effective calibration targeted measures alternative lockdown.

Language: Английский

Citations

0