Health benefits of a five-day at-home modified fasting program: a randomised controlled trial DOI Creative Commons
Franziska Grundler, Quinten R. Ducarmon,

Alfred Holley

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT Background Fasting has been shown to be one of the most cost-effective methods improve cardiometabolic health. We studied a 5-day hypocaloric (∼600 kcal/day) and ketogenic, modified fasting program (MFP) for at-home interventions. hypothesised that this MFP induces metabolic changes comparable 5 days prolonged (75-250kcal/day). Methods tested in two-arm randomised controlled trial where sixty-four healthy subjects were or control group. Serum biochemistry analyses questionnaires allowed determining effects on risk factors. Emotional well-being, possible side physical activity assessed with questionnaires. Biological pathways processes explored nuclear magnetic resonance blood metabolomics gut metagenomics analyses. Results participants (n=32) experienced weight loss (−3.1 ± 1.1 kg) persisting month after intervention. The induced significant, but transient reductions, systolic (−6.4 11.5 mmHg) diastolic (−4.4 7.7 pressure, glucose levels, HbA1c coagulation led greater reductions BMI (p=0.006), pressure (p = 0.009), cholesterol 0.02), LDL 0.02) individuals at diseases compared individuals. Total cholesterol, LDL-C HDL-C levels continued decreasing during food reintroduction. also increased emotional well-being. Blood revealed significant decrease chronic inflammation markers. Shotgun microbiome showed trends relative abundance majority bacterial species their genomic repertoire carbohydrate-active enzymes (CAZymes). This reflected families metabolising dietary fibre substrates an increase host-derived glycan substrates. Comparing previous cohort’s similar changes. Conclusion is safe effectively improves health well-being It offers benefits those observed clinic. practised home, widely accessible compatible individuals’ everyday life.

Language: Английский

Interconnected epidemics: obesity, metabolic syndrome, diabetes and cardiovascular diseases—insights from research and prevention strategies DOI Creative Commons
Abhishek Gupta,

Komal Shah,

Vani Gupta

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 17, 2025

Language: Английский

Citations

0
Health benefits of a five-day at-home modified fasting program: a randomised controlled trial DOI Creative Commons
Franziska Grundler, Quinten R. Ducarmon,

Alfred Holley

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT Background Fasting has been shown to be one of the most cost-effective methods improve cardiometabolic health. We studied a 5-day hypocaloric (∼600 kcal/day) and ketogenic, modified fasting program (MFP) for at-home interventions. hypothesised that this MFP induces metabolic changes comparable 5 days prolonged (75-250kcal/day). Methods tested in two-arm randomised controlled trial where sixty-four healthy subjects were or control group. Serum biochemistry analyses questionnaires allowed determining effects on risk factors. Emotional well-being, possible side physical activity assessed with questionnaires. Biological pathways processes explored nuclear magnetic resonance blood metabolomics gut metagenomics analyses. Results participants (n=32) experienced weight loss (−3.1 ± 1.1 kg) persisting month after intervention. The induced significant, but transient reductions, systolic (−6.4 11.5 mmHg) diastolic (−4.4 7.7 pressure, glucose levels, HbA1c coagulation led greater reductions BMI (p=0.006), pressure (p = 0.009), cholesterol 0.02), LDL 0.02) individuals at diseases compared individuals. Total cholesterol, LDL-C HDL-C levels continued decreasing during food reintroduction. also increased emotional well-being. Blood revealed significant decrease chronic inflammation markers. Shotgun microbiome showed trends relative abundance majority bacterial species their genomic repertoire carbohydrate-active enzymes (CAZymes). This reflected families metabolising dietary fibre substrates an increase host-derived glycan substrates. Comparing previous cohort’s similar changes. Conclusion is safe effectively improves health well-being It offers benefits those observed clinic. practised home, widely accessible compatible individuals’ everyday life.

Language: Английский

Citations

0