ACE2 and TMPRSS2 genetic polymorphisms as potential predictors of COVID−19 severity and outcome in females DOI Creative Commons
Sanja Matić, Dragan Milovanović, Željko Mijailović

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 18, 2024

ACE2 and TMPRSS2 represent the major gateways for SARS-CoV-2 cell entry. The presence of functional genetic polymorphisms that affect gene expression may risk severe form COVID-19 its fatal outcome.

Language: Английский

Managing Labour in Women with COVID-19 DOI Open Access
Victor N. Chilaka, Osric Navti, Albert A. Opoku

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 3980 - 3980

Published: June 12, 2023

Since first reported in December 2019 Wuhan, China, COVID-19 caused by Severe Acute Respiratory Syndrome (SARS) Corona virus2 (SARS CoV-2) quickly spread to become a pandemic that has significant morbidity and mortality. The rapidity of the virus high mortality at outset threatened overwhelm health systems worldwide, and, indeed, this significantly impacted maternal health, especially since there was minimal experience draw from. Experience with Covid 19 grown exponentially as unique needs pregnant labouring women infection have more evident. Managing parturients requires multidisciplinary team consisting anaesthesiologists, obstetricians, neonatologists, nursing staff, critical care infectious disease control experts. There should be clear policy on triaging patients depending severity their condition stage labour. Those risk respiratory failure managed tertiary referral centre facilities for intensive assisted respiration. Staff delivery suites operating rooms protected enforcing protection principles such offering dedicated theatres SARS CoV-2 positive using personal protective equipment. All hospital staff must trained measures which updated regularly. Breastfeeding new-born part healthcare package offered parturient mothers.

Language: Английский

Citations

2
Modelling the Potential Public Health Impact of Different COVID-19 Vaccination Strategies with an Adapted Vaccine in Singapore DOI Creative Commons
Karan Thakkar, Júlia Spinardi, Moe H. Kyaw

et al.

Expert Review of Vaccines, Journal Year: 2023, Volume and Issue: 23(1), P. 16 - 26

Published: Dec. 4, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 has been a dynamically changing virus, requiring the development of adapted vaccines. This study estimated potential public health impact alternative vaccination strategies for in Singapore.

Language: Английский

Citations

2
Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1 DOI Creative Commons

Qiushi Jin,

Ruixue Liu, Wenqi Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Abstract With the SARS-CoV-2 Omicron XBB.1.9 sublineage circulating worldwide, two variants, EG.5.1 and HK.3 spread rapidly became dominant from middle 2023. However, spike features, pathogenicity, transmissibility of are largely unknown. Here, we performed multiscale investigations to reveal virological features subvariants, especially newly emerging HK.3. revealed high replication efficiency in vitro. The exhibited enhanced processing, although its infectivity, fusogenicity, hACE2 binding affinity were comparable those EG.5 XBB.1 spikes. All XBB.1.9.1, strains demonstrated efficient transmission hamsters, XBB.1.9.1 stronger fitness upper airways. greater pathogenicity than BA.2 H11-K18-hACE2 hamsters. Our studies provide insight into pathogens EG.5.1. Importance In animal models, ongoing attenuated poor subvariants seems reach a consensus. our results that including one key variants interest, with another subvariant HK.3, universally both increased highly transmission. This study reemphasized importance surveillance characteristics epidemic subvariants.

Language: Английский

Citations

0
Clinical features of and severity risk factors for COVID-19 in adults during the predominance of SARS-CoV-2 XBB variants in Okinawa, Japan DOI Creative Commons
Shuhei Ideguchi, Kazuya Miyagi, Wakaki Kami

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0309808 - e0309808

Published: Oct. 31, 2024

Since 2023, COVID-19 induced by SARS-CoV-2 XBB variants have been a global epidemic. The variant-induced epidemic was largest in the Okinawa Prefecture among areas Japan, and healthcare institutions burdened increased hospitalizations. This study aimed to evaluate clinical features of risk factors for severe COVID-19.

Language: Английский

Citations

0
ACE2 and TMPRSS2 genetic polymorphisms as potential predictors of COVID−19 severity and outcome in females DOI Creative Commons
Sanja Matić, Dragan Milovanović, Željko Mijailović

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 18, 2024

ACE2 and TMPRSS2 represent the major gateways for SARS-CoV-2 cell entry. The presence of functional genetic polymorphisms that affect gene expression may risk severe form COVID-19 its fatal outcome.

Language: Английский

Citations

0