Global, regional, and national burden of young COPD, 1990–2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Young chronic obstructive pulmonary disease (COPD) refers to people with COPD between the ages of 20 and 50 years. Current epidemiological studies focus on local geography, there is a lack global-level analysis. This study provides in-depth analyses burden young at global, regional, national levels. used Global Burden Disease Study 2021 (GBD). The age-standardised prevalence rate (ASPR), incidence (ASIR), death (ASDR), disability-adjusted life years (DALYs) were describe burden. estimated annual percentage change (EAPC) during period was calculated. Joinpoint regression analysis examined time trend from 1990 2021. Annual (APC) average (AAPC) Risk factors reported by region sex. In 2021, global number cases 30,384,539, ASPR, ASIR, ASDR, DALYs rates fell slightly. Oceania highest rate. High-income North America has ASIR. prevalence, incidence, death, exhibited similar trends, increasing age. From both showed consistent downward across all age groups. indicated slight increase in ASPR (APC: 0.13; 95% CI: 0.06 0.19) ASIR 0.17; 0.10 0.24) 1994. leading attributable risk for are household air pollution solid fuels (20.4%), ambient particulate matter (17.9%), smoking (13.5%). decreased, however, absolute patients increased. shows noticeable regional differences, particularly high burdens observed Oceania. Improving quality, promoting cessation, access lung function tests, raising awareness key strategies alleviating COPD.

Language: Английский

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Intervention in Disease: Study Design (Preprint)

Published: Jan. 12, 2025

Early identification and monitoring of preserved ratio impaired spirometry (PRISm) population active intervention can reduce the incidence rate chronic obstructive pulmonary disease (COPD) delay process. However, there is no evidence on best treatments, effectiveness safety pharmacological interventions poor. Traditional Chinese medicine (TCM) has been used to treat COPD for many years. To clarify clinical efficacy Bufei granules establish a preventive treatment programme reducing with granules, so that provide high-quality evidence-based diagnosis treatment. This multicenter, randomized, double-blind, placebo-controlled trial targeting PRISm population. Volunteers will be randomly divided into two groups, experimental group receiving control placebo granules. The main outcome was COPD, secondary lung function, screening score, quality life, symptoms, 6-minute walking distance (6MWD), dyspnea scor, biochemical indicators economic evaluation. plan last 2 years followed up every 6 months. Compared group, expected improve function life patients, dyspnea, increase exercise tolerance, progression, by approximately 40%. Data released upon completion study. results this study valid in PRISm, resulting high-level TCM prevention slow progression morbidity. promoted use health management departments medical units at all levels expenditure burden disease. ClinicalTrials.gov registration number: NCT06375824.

Language: Английский

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Pulmonary function tests: an integrated approach to interpreting results in the search for treatable traits

Expert Review of Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Introduction Technological advances have led to the proliferation of lung function assessment techniques beyond spirometry in most countries. At same time, new knowledge respiratory physiology has allowed an expansion parameters, requiring integrated approach interpreting results.

Language: Английский

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Research Progress of Clinical Application of Pulmonary Function Test

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1533 - 1543

Published: Jan. 1, 2025

Language: Английский

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Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study

International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 287 - 302

Published: Feb. 1, 2025

Background: Preserved ratio impaired spirometry (PRISm) is defined as forced expiratory volume in one second (FEV 1 )/forced vital capacity (FVC)≥ 0.70 and FEV < 80% predicted. Previous studies have shown that individuals with PRISm may develop airflow obstruction an increased mortality risk. However, long-term follow-up are lacking, this topic has not been evaluated the general population. We explored all-cause risk of a large sample Methods: used data from National Health Nutrition Examination Survey III 2007– 2012. Participants aged 20– 79 years at baseline who underwent were included. Normal was prebronchodilator /FVC≥ ≥ Cox proportional hazards regression models to compare between groups. performed sensitivity analyses stratified by lower limit normal definition criteria. Subgroup sex, age, smoking status, race, body mass index, level education, poverty-to-income ratio, respiratory symptoms, comorbidities participants different classifications. Results: Overall, 24,691 included, median time 25.7 years. Of these, 19,969 had 1,452 PRISm. associated high (unadjusted hazard [HR]=2.47, 95% confidence interval [CI]: 2.25– 2.71, P< 0.001; adjusted HR=1.69, CI: 1.54– 1.86, 0.001) compared spirometry. Sensitivity subgroup showed similar Conclusion: Our finding revealed significantly population Further research needed explore intervention effect Keywords: PRISm, preserved spirometry, mortality, symptom, comorbidity

Language: Английский

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Plasma IgG Glycosylation Profiling Reveals the Biological Features of Early Chronic Obstructive Pulmonary Disease

Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Chronic inflammatory and immune dysregulation are critical drivers of the development progression chronic obstructive pulmonary disease (COPD). Posttranslational modifications, such as glycosylation Immunoglobulin G (IgG), crucial in modulating systemic homeostasis. This study aims to profile plasma IgG glycopeptides (IgGPs) COPD patients uncover new insights into their pathogenesis identify novel biomarkers. An integrated platform that combines Fe3O4@PDA@DETA nanospheres enrichment with high-resolution mass spectrometry measurement was employed analyze N-glycopeptides from 90 patients, 45 clinically defined early (CECOPD) healthy individuals. To explore underlying mechanism progression, correlations between N-glycoforms clinical parameters were assessed. Disease-specific IgGPs identified both ECOPD cohorts. Notably, it glycopattern, rather than levels themselves, underwent changes progressed. In there a decrease bisection, accompanied by an increase site-specific afucosylated galactosylation fucosylation IgG, indicating anti-inflammatory state. Conversely, inflammation observed, which characterized reduced sialylation. Interestingly, subset controls displayed IgGP patterns similar those COPD, possibly reflecting impact smoking associated responses. We finally 6 2 pro-inflammatory ECOPD-specific indicators. Collectively, these findings suggest holds great potential biomarker for diagnosis, providing valuable system during progression. The raw data files publicly accessible via ProteomeXchange Consortium identifier PXD056374.

Language: Английский

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Associations between life’s essential 8 and preserved ratio impaired spirometry

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 10, 2025

Preserved ratio impaired spirometry (PRISm) is a prevalent yet under-researched state of diminished lung function, which has been proposed as pre-clinical abnormal associated with chronic obstructive pulmonary disease (COPD) or early-stage COPD. PRISm closely cardiovascular disease. Preventing and improving quality life in subjects important. We aimed to examined the relationship between American Heart Association's Life's Essential 8 (LE8) PRISm. This cross-sectional study utilized data 2,869 adults aged ≥ 20 years from National Health Nutrition Examination Survey (NHANES) 2007–2012. Multivariable logistic regression models were employed examine association LE8 score, health behavior factor each component Moreover, explored this correlation greater depth using restricted cubic spline curves subgroup analyses. Of participants, mean age was 44.09 ± 0.44 years, 316 (11.01%) defined having In fully adjusted models, higher scores reduced odds for (OR = 0.97; 95% CI, 0.96–0.98). A linear score observed. Similar patterns emerged subscores, particularly stronger factors analysis, inverse significantly more pronounced among those high income. lower likelihood developing Promoting optimal adherence metrics may improve offers meaningful approach its prevention management.

Language: Английский

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The Effect of Out‐of‐Hospital Extended Care on the Prognosis of Patients With Chronic Obstructive Pulmonary Disease

Journal of Evaluation in Clinical Practice, Journal Year: 2025, Volume and Issue: 31(2)

Published: March 1, 2025

ABSTRACT Objective Nursing services are crucial for the recovery and prognosis of patients with chronic obstructive pulmonary disease (COPD). This study is to evaluate impact out‐of‐hospital extended care on COPD. Methods A total 67 COPD were enroled in this study, divided into a control group an intervention group. The was provided 6 months, at end follow‐up visit, patients' psychological status, function, exercise endurance assessed. Results Compared group, showed significant improvement as reflected FVC, FEV1, FEV1%, FEV1/FVC. Meanwhile, after months services, endurance, increase 6‐min walking distance. In addition, experienced reduction anxiety depression services. Conclusions Extended service new model can significantly improve patients.

Language: Английский

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Associated Factors and Pulmonary Function Outcomes of Preserved Ratio Impaired Spirometry: A Scoping Review

International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 767 - 784

Published: March 1, 2025

Preserved ratio impaired spirometry (PRISm) is a common but understudied abnormal pulmonary function state and strongly associated with poor health outcomes. However, there lack of uniformity in defining the factors outcomes PRISm. This scoping review aims to elucidate PRISm, thereby enhancing healthcare professionals' understanding PRISm laying groundwork for its prevention treatment. follows 5-step framework developed by Arksey O'Malley. Literature on was systematically searched from databases including PubMed, Embase, CINAHL, Cochrane Library, Web Science, CNKI, Wan Fang, spanning inception July 2024. Inclusion exclusion criteria were applied enroll relevant studies. Data extracted, collected, summarized, reported. A total 38 studies included. The analysis revealed that encompass possible pathogenic (older age, female, lower education level, smoking, obesity, etc), comorbidity associations (asthma, diabetes, cardiovascular diseases, disease characteristic (disease burden, physical performance, radiological characteristics, etc). status population unstable, making progression airflow obstruction (AFO) more likely than normal population. exhibits multiple subgroups (incident or stable definite AFO, non-restrictive restrictive etc) significant differences exist among different subgroups. offers comprehensive It recommended future research focus deeper investigation elucidating pathophysiological proposing new strategies Furthermore, needed low-income middle-income economies understand comprehensively.

Language: Английский

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AutoCOPD–A novel and practical machine learning model for COPD detection using whole-lung inspiratory quantitative CT measurements: a retrospective, multicenter study

EClinicalMedicine, Journal Year: 2025, Volume and Issue: 82, P. 103166 - 103166

Published: April 1, 2025

The rate of diagnosis for chronic obstructive pulmonary disease (COPD) is low worldwide. Quantitative computed tomography (QCT) parameters add value to quantify alterations in airway and lung parenchyma COPD. This study aimed assess the performance QCT features COPD detection using a whole-lung inspiratory CT model. multicenter retrospective was performed on 4106 participants. derivation cohort containing 1950 participants who enrolled Guangzhou communities from August 2017 December 2019, separated training internal validation cohorts, three external cohorts 1703 were recruited public hospitals (Cohort 1: First Affiliated Hospital Medical University; Cohort 2: Xiangyang central hospital; 3: Second Xi'an Jiaotong University) China between April May 2024. Questionnaire information, reports, derived extracted model development. A novel multimodal framework eXtreme gradient boosting hybrid feature selection established detection. National Lung Screening Trial (NLST) (n = 453) applied validate multiracial extrapolation robustness low-dose scans. (referred as AutoCOPD) with ten achieved highest AUC 0·860 (95% CI: 0·823-0·898) cohort, showed excellent discrimination when externally validated [Cohort 0·915 0·898-0·931); 0·903 0·864-0·943); 0·914 0·882-0·947); NLST: 0·881 0·846-0·915)]. Decision curve analysis demonstrated that AutoCOPD valuable across range risk thresholds 0·12 0·66 compared intervention all patients or no intervention. Heterogeneous can be well identified (https://lwj-lab.shinyapps.io/autocopd/) constructed by subset only features. It may generalizable clinical settings serve feasible tool early detecting mild asymptomatic reduce delayed routine practice. Natural Science Foundation China, Laboratory, Guangdong Province, Municipal Technology grant, State Key Laboratory Respiratory Disease.

Language: Английский

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