Prevalence, Risk Factors of Preserved Ratio Impaired Spirometry in adult in plateau: A Cross-Sectional Study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0318546 - e0318546

Published: April 10, 2025

Background Preserved ratio impaired spirometry(PRISm) is considered to be a precursor of COPD. The purpose our study investigate the prevalence and risk factors PRISm in high-altitude areas. Methods adult residents Hongyuan County were selected by random sampling method, lung function tests, questionnaires, blood tests conducted. was compared among different investigation, binary logistic regression analysis used determine independent influencing PRISm. Results 627 participants qualified for quality control, 10.06%. age 40–49 years old(OR = 4.322,95%CI: 1.149–16.262),age ≧ 60 (OR 4.453, 95% CI: 1.003–19.762),Body mass index 30(OR: 3.745, 1.611–8.707),Smoking (OR: 2.591, 1.305–5.146), Diabetes 3.894, 1.043–14.199), history pulmonary tuberculosis 13.678, 5.495–34.049), hypertension(OR: 3.447, 1.529–7.771), White cell count(OR: 1.414, 1.164–1.717), Red volume distribution width 1.098, 1.009–1.196). Conclusion 10.03%; included age, smoking, tuberculosis, diabetes,hypertension,body 30,Red width.

Language: Английский

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Epidemiological trends and risk factors of chronic obstructive pulmonary disease in young individuals based on the 2021 global burden of disease data (1990–2021)

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 12, 2025

Language: Английский

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COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study

BMC Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 15, 2024

Abstract Chronic obstructive pulmonary disease (COPD) has been associated with alterations in the brain cortical structure. Nonetheless, causality between COPD and structure not determined. In present study, we used Mendelian randomization (MR) analysis to explore causal effects of genetic predicated on structure, namely surface area (SA) thickness (TH). Genetic association summary data for were obtained from FinnGen consortium ( N = 358,369; Ncase 20,066). PRISm retrieved a case–control GWAS conducted UK Biobank 296,282). Lung function indices, including forced expiratory volume one second (FEV1), vital capacity (FVC), FEV1/FVC, extracted meta-analysis SpiroMeta 400,102). Brain ENIGMA 51,665). Inverse-variance weighted (IVW) method was as primary analysis, series sensitivity tests exploited evaluate heterogeneity pleiotropy our results. The results identified potential several specifications, pars orbitalis, cuneus inferior parietal gyrus. Furthermore, lung index (FEV1, FVC FEV1/FVC), well PRISm, also According results, total 15 functional specifications influenced by PRISm. These findings contribute understanding

Language: Английский

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Exploring the pathways of urban green space exposure on respiratory health: An empirical study in Nanjing, China

Urban forestry & urban greening, Journal Year: 2024, Volume and Issue: 101, P. 128536 - 128536

Published: Oct. 5, 2024

Language: Английский

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Effects and mechanism of combination of Platycodon grandiflorum polysaccharides and Platycodon saponins in the treatment of chronic obstructive pulmonary disease rats through the gut-lung axis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119305 - 119305

Published: Dec. 1, 2024

Language: Английский

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Association between impaired diffusion capacity and small airway dysfunction: a cross-sectional study

ERJ Open Research, Journal Year: 2024, Volume and Issue: 11(1), P. 00910 - 2023

Published: Aug. 1, 2024

Background Small airway dysfunction (SAD) and impaired diffusion capacity of the lungs for carbon monoxide ( D LCO ) are positively associated with a worse prognosis. Individuals both dysfunctions have been identified in clinical practice it is unknown whether they health status or need management. We conducted this study to explore association between SAD , difference groups two dysfunctions, either one no dysfunction. Methods This involved subjects partly from those who had returned third-year follow-up (up December 2022) Early Chronic Obstructive Pulmonary Disease newly participated. assessed capacity, questionnaire, exacerbations, spirometry, impulse oscillometry (IOS) computed tomography (CT). Impaired was defined as <80% predicted. Spirometry-defined using percent predicted values maximal mid-expiratory flow, forced expiratory flow at 50% 75% vital least these three being <65% after use bronchodilator. IOS-defined when resistance 5 20 Hz >0.07 kPa·L −1 ·s. CT-defined percentage low-attenuation areas <−856 HU comprised ≥15% total lung volume. Covariate analyses logistic regression were performed assess SAD. Results 581 subjects. The occurrence spirometry- significantly higher than normal . Subjects preceding year's exacerbations controls. Conclusions may additional

Language: Английский

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Research Progress in Preserved Ratio Impaired Spirometry

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(08), P. 1162 - 1168

Published: Jan. 1, 2024

Language: Английский

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Associations Between Physical Activity and Preserved Ratio Impaired Spirometry: A Cross-Sectional NHANES Study

International Journal of COPD, Journal Year: 2024, Volume and Issue: Volume 19, P. 2517 - 2528

Published: Nov. 1, 2024

Preserved ratio impaired spirometry (PRISm) is considered to be one of the early chronic obstructive pulmonary disease states, and there are few studies on PRISm prevention. We aimed evaluate relationship between physical activity risk PRISm.

Language: Английский

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