Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Background The relationship between COVID-19 infection and a possible increased likelihood of older adults developing new-onset dementia (NOD) remains elusive. Methods A thorough search was performed across several databases including MEDLINE/PubMed, PsycINFO, Scopus, medRxiv, PQDT Global for studies published in English from January 2020 to December 2023. Only original investigations exploring the link NOD were selected inclusion. We assessed risk NOD, using Risk Ratio (RR) measurement. Control groups categorized as: (i) non-COVID cohort with other respiratory infections [control group (C1)]; (ii) otherwise unspecified health status (C2)]. Follow-up periods divided into intervals 3, 6, 12, 24 months post-COVID. Results 11 (involving 939,824 post-COVID-19 survivors 6,765,117 controls) included review. Across median observation period 12 post-COVID, overall incidence about 1.82% COVID-infected group, compared 0.35% non-COVID-infected group. pooled meta-analysis showed significantly among adult non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). Similar risks observed subgroup analyses restricted an observational 1.56, 1.21–2.01), as well five that employed propensity score matching sufficiently effectively control multiple confounding covariates 1.46, 1.10–1.94). C1 shared comparably (overall RR 1.13, 0.92–1.38). Discussion Under normal circumstances, we believe is likely be factor over time. While due appears similar associated infections, it warrants necessitates investigation longer observations.

Language: Английский

COVID-19 Infection Associated with Increased Risk of New-Onset Vascular Dementia in Adults Aged 50 Years and Older: A Longitudinal Cohort Study Using Data from the UK Biobank

Published: Jan. 1, 2025

Language: Английский