Frontiers in Physiology,
Journal Year:
2021,
Volume and Issue:
12
Published: Sept. 6, 2021
Fatigue
poses
an
important
safety
risk
to
civil
and
military
aviation.
In
addition
decreasing
performance
in-flight
(chronic)
fatigue
has
negative
long-term
health
effects.
Possible
causes
of
include
sleep
loss,
extended
time
awake,
circadian
phase
irregularities
work
load.
Despite
regulations
limiting
flight
enabling
optimal
rostering,
cannot
be
prevented
completely.
Especially
in
operations,
where
limits
may
due
operational
necessities,
it
is
impossible
rely
solely
on
prevent
fatigue.
management,
consisting
preventive
strategies
countermeasures,
such
as
pre-flight
naps
pharmaceuticals
that
either
promote
adequate
(hypnotics
or
chronobiotics)
enhance
(stimulants),
required
mitigate
challenging
(military)
aviation
operations.
This
review
describes
the
pathophysiology,
epidemiology
effects
its
impact
aviation,
well
several
aspects
management
recommendations
for
future
research
this
field.
Abstract
Great
progress
made
by
heteroepitaxial
growth
technology
encourages
rapid
development
of
III‐nitride
structures
and
their
applications
in
extensive
fields.
Particularly,
innate
bandgap
tunability
materials
renders
them
attractive
for
white
light‐emitting
diodes
(WLEDs)
that
are
considered
as
next‐generation
solid‐state
lighting
sources.
However,
commercial
phosphor‐converted
WLEDs
suffer
from
poor
color
rendering
index
(CRI)
intense
blue
component,
hard
to
fulfill
demanding
requirements
simultaneously
energy
efficiency
healthy
lighting.
Here,
an
efficient
full‐spectrum
WLED
excited
monolithically
integrated
quantum
structure
is
reported,
which
trichromatic
InGaN/GaN
multiple
wells
constructed
engineering
heteroepitaxy
allowing
flexible
regulation
indium
composition
barrier
thickness
manipulate
carrier
transport
behavior.
Furthermore,
relationship
between
structural
parameters
emission
characteristics
well
impact
on
light
performance
systematically
demonstrated.
Combined
with
commonly
used
green‐red
phosphor
mixture,
the
fabricated
warm/cold
can
emit
broadband
continuous
spectra
low‐ratio
first
exhibiting
superior
CRI
(>
97/98),
fidelity
(97/97),
saturation
(100/99),
luminous
efficacy
(>120/140
lm
W
−1
).
This
work
demonstrates
advantages
bandgap‐engineered
applied
excitation
source,
opens
up
new
avenues
exploration
high‐quality
JAMA Internal Medicine,
Journal Year:
2019,
Volume and Issue:
179(8), P. 1061 - 1061
Published: June 10, 2019
Importance
Short
sleep
has
been
associated
with
obesity,
but
to
date
the
association
between
exposure
artificial
light
at
night
(ALAN)
while
sleeping
and
obesity
is
unknown.
Objective
To
determine
whether
ALAN
prevalence
risk
of
obesity.
Design,
Setting,
Participants
This
baseline
prospective
analysis
included
women
aged
35
74
years
enrolled
in
Sister
Study
all
50
US
states
Puerto
Rico
from
July
2003
through
March
2009.
Follow-up
was
completed
on
August
14,
2015.
A
total
43
722
no
history
cancer
or
cardiovascular
disease
who
were
not
shift
workers,
daytime
sleepers,
pregnant
analysis.
Data
analyzed
September
1,
2017,
December
31,
2018.
Exposures
Artificial
reported
enrollment,
categorized
as
light,
small
nightlight
room,
outside
television
room.
Main
Outcomes
Measures
Prevalent
based
measured
general
(body
mass
index
[BMI]
≥30.0)
central
(waist
circumference
[WC]
≥88
cm,
waist-to-hip
ratio
[WHR]
≥0.85,
waist-to-height
[WHtR]≥0.5).
evaluate
incident
overweight
self-reported
BMI
enrollment
compared
follow-up
(mean
[SD]
follow-up,
5.7
[1.0]
years).
Generalized
log-linear
models
robust
error
variance
used
estimate
multivariable-adjusted
ratios
(PRs)
relative
risks
(RRs)
95%
CIs
for
prevalent
Results
Among
population
age,
55.4
[8.9]
years),
having
any
positively
a
higher
baseline,
using
(PR,
1.03;
CI,
1.02-1.03),
WC
1.12;
1.09-1.16),
WHR
1.04;
1.00-1.08),
WHtR
1.07;
1.04-1.09),
after
adjusting
confounding
factors,
withP
<
.001
trend
each
measure.
Having
also
(RR,
1.19;
1.06-1.34).
Compared
ALAN,
room
gaining
5
kg
more
1.17;
1.08-1.27;P
trend),
increase
10%
1.13;
1.02-1.26;P
=
.04
1.22;
CI,1.06-1.40;
P
.03
1.33;
1.13-1.57;P
trend).
Results
supported
by
sensitivity
analyses
additional
multivariable
including
potential
mediators
such
duration
quality,
diet,
physical
activity.
Conclusions
Relevance
These
results
suggest
that
may
be
factor
weight
gain
development
Further
interventional
studies
could
help
elucidate
this
clarify
lowering
can
promote
prevention.
Journal of Pineal Research,
Journal Year:
2020,
Volume and Issue:
69(3)
Published: July 13, 2020
Abstract
Almost
all
living
organisms
have
evolved
autoregulatory
transcriptional‐translational
feedback
loops
that
produce
oscillations
with
a
period
of
approximately
24‐h.
These
endogenous
time
keeping
mechanisms
are
called
circadian
clocks.
The
main
function
these
clocks
is
to
drive
overt
rhythms
in
the
physiology
ensure
physiological
functions
synchrony
external
environment.
Disruption
caused
by
genetic
or
environmental
factors
has
long‐term
consequences
for
metabolic
health.
Of
relevance,
host
rhythmicity
and
lipid
metabolism
increasingly
recognized
cross‐regulate
clock‐lipid
interplay
may
involve
development
obesity.
Multiple
systemic
molecular
mechanisms,
such
as
hormones
(ie,
melatonin,
leptin,
glucocorticoid),
gut
microbiome,
energy
metabolism,
link
clock
predictably,
deregulation
can
increase
risk
obesity,
which
turn
exacerbate
disorganization.
Feeding
dietary
nutrients
two
key
Zeitgebers
affecting
rhythm‐lipid
interplay,
influencing
obesity
highlighted
this
review.
Together,
characterization
machinery
aimed
at
producing
healthy
lifestyle
improve
care.
Journal of Translational Medicine,
Journal Year:
2020,
Volume and Issue:
18(1)
Published: Aug. 18, 2020
Abstract
Background
COVID
19
-
related
quarantine
led
to
a
sudden
and
radical
lifestyle
changes,
in
particular
eating
habits.
Objectives
of
the
study
were
investigate
effect
on
sleep
quality
(SQ)
body
mass
index
(BMI),
if
change
SQ
was
working
modalities.
Materials
We
enrolled
121
adults
(age
44.9
±
13.3
years
35.5%
males).
Anthropometric
parameters,
modalities
physical
activity
studied.
Sleep
evaluated
by
Pittsburgh
Quality
Index
(PSQI)
questionnaire.
At
baseline,
subjects
assessed
outpatient
clinic
after
40
days
quarantine/lockdown
phone
interview.
Results
Overall,
49.6%
good
sleepers
(PSQI
<
5)
at
baseline
significantly
decreased
(
p
0.001).
In
detail,
onset
latency
0.001),
efficiency
=
0.03),
disturbances
daytime
dysfunction
0.001)
worsened.
There
also
significant
increase
BMI
values
normal
weight
0.023),
grade
I
0.027)
II
obesity
0.020).
all
cohort,
0.004).
However,
analyzing
data
according
gender
difference,
males
as
well
females
which
there
only
trend
without
reaching
statistical
significance
(53.5%
vs
25.6%;
0.015
50.0%
35.9%,
0.106;
females,
respectively).
addition,
smart
resulted
worsening
SQ,
particularly
Conclusions
Quarantine
associated
doing
working,
an
values.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(16), P. 5804 - 5804
Published: Aug. 13, 2020
Ionizing
radiation
(IR)
has
found
widespread
application
in
modern
medicine,
including
medical
imaging
and
radiotherapy.
As
a
result,
both
patients
healthcare
professionals
are
exposed
to
various
IR
doses.
To
minimize
the
negative
side
effects
of
associated
with
oxidative
imbalance,
antioxidant
therapy
been
considered.
In
this
review,
studies
on
melatonin
vitamin
D
radiation-induced
stress
discussed.
According
research
data,
substances
meet
conditions
for
use
as
agents
that
protect
humans
against
IR-induced
tissue
damage.
Numerous
have
confirmed
melatonin,
hydro-
lipophilic
hormone
strong
properties,
can
potentially
be
used
radioprotectant
humans.
Less
is
known
about
radioprotective
D,
but
results
date
promising.
Deficiencies
common
societies
may
contribute
severity
adverse
exposure.
Hence,
supporting
supplementation
seems
first
importance.
Interestingly,
selectively
radiosensitise
cancer
cells,
which
makes
them
promising
adjuvants
More
needed
area,
especially