Fatigue in Aviation: Safety Risks, Preventive Strategies and Pharmacological Interventions DOI Creative Commons
Yara Q. Wingelaar-Jagt, Thijs T. Wingelaar, Wim J. Riedel

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 6, 2021

Fatigue poses an important safety risk to civil and military aviation. In addition decreasing performance in-flight (chronic) fatigue has negative long-term health effects. Possible causes of include sleep loss, extended time awake, circadian phase irregularities work load. Despite regulations limiting flight enabling optimal rostering, cannot be prevented completely. Especially in operations, where limits may due operational necessities, it is impossible rely solely on prevent fatigue. management, consisting preventive strategies countermeasures, such as pre-flight naps pharmaceuticals that either promote adequate (hypnotics or chronobiotics) enhance (stimulants), required mitigate challenging (military) aviation operations. This review describes the pathophysiology, epidemiology effects its impact aviation, well several aspects management recommendations for future research this field.

Language: Английский

Monolithically Integrating III‐Nitride Quantum Structure for Full‐Spectrum White LED via Bandgap Engineering Heteroepitaxial Growth DOI

Benjie Fan,

Xiaoyu Zhao, Jingqiong Zhang

et al.

Laser & Photonics Review, Journal Year: 2023, Volume and Issue: 17(3)

Published: Jan. 1, 2023

Abstract Great progress made by heteroepitaxial growth technology encourages rapid development of III‐nitride structures and their applications in extensive fields. Particularly, innate bandgap tunability materials renders them attractive for white light‐emitting diodes (WLEDs) that are considered as next‐generation solid‐state lighting sources. However, commercial phosphor‐converted WLEDs suffer from poor color rendering index (CRI) intense blue component, hard to fulfill demanding requirements simultaneously energy efficiency healthy lighting. Here, an efficient full‐spectrum WLED excited monolithically integrated quantum structure is reported, which trichromatic InGaN/GaN multiple wells constructed engineering heteroepitaxy allowing flexible regulation indium composition barrier thickness manipulate carrier transport behavior. Furthermore, relationship between structural parameters emission characteristics well impact on light performance systematically demonstrated. Combined with commonly used green‐red phosphor mixture, the fabricated warm/cold can emit broadband continuous spectra low‐ratio first exhibiting superior CRI (> 97/98), fidelity (97/97), saturation (100/99), luminous efficacy (>120/140 lm W −1 ). This work demonstrates advantages bandgap‐engineered applied excitation source, opens up new avenues exploration high‐quality

Language: Английский

Citations

88

Night Shift Work and Risk of Breast Cancer DOI
Johnni Hansen

Current Environmental Health Reports, Journal Year: 2017, Volume and Issue: 4(3), P. 325 - 339

Published: Aug. 2, 2017

Language: Английский

Citations

151

Light at night as an environmental endocrine disruptor DOI
Kathryn L.G. Russart, Randy J. Nelson

Physiology & Behavior, Journal Year: 2017, Volume and Issue: 190, P. 82 - 89

Published: Sept. 7, 2017

Language: Английский

Citations

147

Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women DOI Open Access
Yong‐Moon Park, Alexandra J. White, Chandra L. Jackson

et al.

JAMA Internal Medicine, Journal Year: 2019, Volume and Issue: 179(8), P. 1061 - 1061

Published: June 10, 2019

Importance

Short sleep has been associated with obesity, but to date the association between exposure artificial light at night (ALAN) while sleeping and obesity is unknown.

Objective

To determine whether ALAN prevalence risk of obesity.

Design, Setting, Participants

This baseline prospective analysis included women aged 35 74 years enrolled in Sister Study all 50 US states Puerto Rico from July 2003 through March 2009. Follow-up was completed on August 14, 2015. A total 43 722 no history cancer or cardiovascular disease who were not shift workers, daytime sleepers, pregnant analysis. Data analyzed September 1, 2017, December 31, 2018.

Exposures

Artificial reported enrollment, categorized as light, small nightlight room, outside television room.

Main Outcomes Measures

Prevalent based measured general (body mass index [BMI] ≥30.0) central (waist circumference [WC] ≥88 cm, waist-to-hip ratio [WHR] ≥0.85, waist-to-height [WHtR]≥0.5). evaluate incident overweight self-reported BMI enrollment compared follow-up (mean [SD] follow-up, 5.7 [1.0] years). Generalized log-linear models robust error variance used estimate multivariable-adjusted ratios (PRs) relative risks (RRs) 95% CIs for prevalent

Results

Among population age, 55.4 [8.9] years), having any positively a higher baseline, using (PR, 1.03; CI, 1.02-1.03), WC 1.12; 1.09-1.16), WHR 1.04; 1.00-1.08), WHtR 1.07; 1.04-1.09), after adjusting confounding factors, withP < .001 trend each measure. Having also (RR, 1.19; 1.06-1.34). Compared ALAN, room gaining 5 kg more 1.17; 1.08-1.27;P trend), increase 10% 1.13; 1.02-1.26;P = .04 1.22; CI,1.06-1.40; P .03 1.33; 1.13-1.57;P trend). Results supported by sensitivity analyses additional multivariable including potential mediators such duration quality, diet, physical activity.

Conclusions Relevance

These results suggest that may be factor weight gain development Further interventional studies could help elucidate this clarify lowering can promote prevention.

Language: Английский

Citations

128

Circadian rhythms and obesity: Timekeeping governs lipid metabolism DOI
Yuying Li, Jie Ma, Yao Kang

et al.

Journal of Pineal Research, Journal Year: 2020, Volume and Issue: 69(3)

Published: July 13, 2020

Abstract Almost all living organisms have evolved autoregulatory transcriptional‐translational feedback loops that produce oscillations with a period of approximately 24‐h. These endogenous time keeping mechanisms are called circadian clocks. The main function these clocks is to drive overt rhythms in the physiology ensure physiological functions synchrony external environment. Disruption caused by genetic or environmental factors has long‐term consequences for metabolic health. Of relevance, host rhythmicity and lipid metabolism increasingly recognized cross‐regulate clock‐lipid interplay may involve development obesity. Multiple systemic molecular mechanisms, such as hormones (ie, melatonin, leptin, glucocorticoid), gut microbiome, energy metabolism, link clock predictably, deregulation can increase risk obesity, which turn exacerbate disorganization. Feeding dietary nutrients two key Zeitgebers affecting rhythm‐lipid interplay, influencing obesity highlighted this review. Together, characterization machinery aimed at producing healthy lifestyle improve care.

Language: Английский

Citations

123

Health and wellness in commercial buildings: Systematic review of sustainable building rating systems and alignment with contemporary research DOI
J.J. McArthur, Colin Powell

Building and Environment, Journal Year: 2020, Volume and Issue: 171, P. 106635 - 106635

Published: Jan. 6, 2020

Language: Английский

Citations

121

The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease DOI
Hao Wu,

Sophie Dunnett,

YS Ho

et al.

Frontiers in Neuroendocrinology, Journal Year: 2019, Volume and Issue: 54, P. 100764 - 100764

Published: May 15, 2019

Language: Английский

Citations

118

Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats DOI

Tao Wu,

Luna Yang, Jian‐Guo Jiang

et al.

Life Sciences, Journal Year: 2017, Volume and Issue: 192, P. 173 - 182

Published: Dec. 1, 2017

Language: Английский

Citations

116

Does Sars-Cov-2 threaten our dreams? Effect of quarantine on sleep quality and body mass index DOI Creative Commons
Luigi Barrea,

Gabriella Pugliese,

Lydia Framondi

et al.

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Aug. 18, 2020

Abstract Background COVID 19 - related quarantine led to a sudden and radical lifestyle changes, in particular eating habits. Objectives of the study were investigate effect on sleep quality (SQ) body mass index (BMI), if change SQ was working modalities. Materials We enrolled 121 adults (age 44.9 ± 13.3 years 35.5% males). Anthropometric parameters, modalities physical activity studied. Sleep evaluated by Pittsburgh Quality Index (PSQI) questionnaire. At baseline, subjects assessed outpatient clinic after 40 days quarantine/lockdown phone interview. Results Overall, 49.6% good sleepers (PSQI < 5) at baseline significantly decreased ( p 0.001). In detail, onset latency 0.001), efficiency = 0.03), disturbances daytime dysfunction 0.001) worsened. There also significant increase BMI values normal weight 0.023), grade I 0.027) II obesity 0.020). all cohort, 0.004). However, analyzing data according gender difference, males as well females which there only trend without reaching statistical significance (53.5% vs 25.6%; 0.015 50.0% 35.9%, 0.106; females, respectively). addition, smart resulted worsening SQ, particularly Conclusions Quarantine associated doing working, an values.

Language: Английский

Citations

105

Ionizing Radiation as a Source of Oxidative Stress—The Protective Role of Melatonin and Vitamin D DOI Open Access
Jarosław Nuszkiewicz, Alina Woźniak, Karolina Szewczyk‐Golec

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(16), P. 5804 - 5804

Published: Aug. 13, 2020

Ionizing radiation (IR) has found widespread application in modern medicine, including medical imaging and radiotherapy. As a result, both patients healthcare professionals are exposed to various IR doses. To minimize the negative side effects of associated with oxidative imbalance, antioxidant therapy been considered. In this review, studies on melatonin vitamin D radiation-induced stress discussed. According research data, substances meet conditions for use as agents that protect humans against IR-induced tissue damage. Numerous have confirmed melatonin, hydro- lipophilic hormone strong properties, can potentially be used radioprotectant humans. Less is known about radioprotective D, but results date promising. Deficiencies common societies may contribute severity adverse exposure. Hence, supporting supplementation seems first importance. Interestingly, selectively radiosensitise cancer cells, which makes them promising adjuvants More needed area, especially

Language: Английский

Citations

103