Journal of Traditional Chinese Medical Sciences,
Journal Year:
2021,
Volume and Issue:
8(4), P. 267 - 279
Published: Oct. 1, 2021
In
addition
to
the
respiratory
system,
severe
acute
syndrome
coronavirus
2
(SARS-CoV-2)
strikes
other
systems,
including
digestive,
circulatory,
urogenital,
and
even
central
nervous
as
its
receptor
angiotensin-converting
enzyme
(ACE2)
is
expressed
in
various
organs,
such
lungs,
intestine,
heart,
esophagus,
kidneys,
bladder,
testis,
liver,
brain.
Different
mechanisms,
particular,
massive
virus
replication,
extensive
apoptosis
necrosis
of
lung-related
epithelial
endothelial
cells,
vascular
leakage,
hyper-inflammatory
responses,
overproduction
pro-inflammatory
mediators,
cytokine
storm,
oxidative
stress,
downregulation
ACE2,
impairment
renin-angiotensin
system
contribute
COVID-19
pathogenesis.
Currently,
a
global
pandemic
with
no
specific
anti-viral
treatment.
The
favorable
capabilities
ginger
were
indicated
patients
suffering
from
osteoarthritis,
neurodegenerative
disorders,
rheumatoid
arthritis,
type
diabetes,
distress,
liver
diseases
primary
dysmenorrheal.
Ginger
or
compounds
exhibited
strong
anti-inflammatory
anti-oxidative
influences
numerous
animal
models.
This
review
provides
evidence
regarding
potential
effects
against
SARS-CoV-2
infection
highlights
antiviral,
anti-inflammatory,
antioxidative,
immunomodulatory
impacts
an
attempt
consider
this
plant
alternative
therapeutic
agent
for
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 10, 2021
Macrophages
are
cells
that
mediate
both
innate
and
adaptive
immunity
reactions,
playing
a
major
role
in
physiological
pathological
processes.
Systemic
SARS-CoV-2-associated
complications
include
acute
respiratory
distress
syndrome
(ARDS),
disseminated
intravascular
coagulation
syndrome,
edema,
pneumonia.
These
predominantly
effects
of
massive
macrophage
activation
collectively
can
be
defined
as
syndrome.
In
this
review
we
focus
on
the
macrophages
COVID-19,
pathogenesis
new
coronavirus
infection,
especially
cases
complicated
by
ARDS,
largely
depends
phenotypes
functionalities.
We
describe
participation
monocytes,
monocyte-derived
resident
lung
ARDS
discuss
possible
utility
cell
therapies
for
its
treatment,
notably
use
reprogrammed
with
stable
pro-
or
anti-inflammatory
phenotypes.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(24), P. 9644 - 9644
Published: Dec. 17, 2020
Cell-cell
fusion
between
eukaryotic
cells
is
a
general
process
involved
in
many
physiological
and
pathological
conditions,
including
infections
by
bacteria,
parasites,
viruses.
As
obligate
intracellular
pathogens,
viruses
use
machineries
pathways
for
efficient
replication
their
host
target
cells.
Interestingly,
certain
viruses,
and,
more
especially,
enveloped
belonging
to
different
viral
families
human
can
mediate
cell-cell
infected
neighboring
non-infected
Depending
of
the
cellular
environment
tissue
organization,
this
virus-mediated
leads
merge
membrane
cytoplasm
contents
formation
multinucleated
cells,
also
called
syncytia,
that
express
high
amount
antigens
tissues
organs
hosts.
This
ability
some
trigger
as
virus-donor
surrounding
mainly
related
virus-encoded
proteins,
known
fusogens
displaying
fusogenic
properties,
expressed
at
cell
surface
Virus-induced
then
mediated
interactions
these
proteins
with
molecules
or
receptors
virus
entry
on
Thus,
goal
review
give
an
overview
animal
families,
special
focus
fusion.
Journal of Traditional Chinese Medical Sciences,
Journal Year:
2021,
Volume and Issue:
8(4), P. 267 - 279
Published: Oct. 1, 2021
In
addition
to
the
respiratory
system,
severe
acute
syndrome
coronavirus
2
(SARS-CoV-2)
strikes
other
systems,
including
digestive,
circulatory,
urogenital,
and
even
central
nervous
as
its
receptor
angiotensin-converting
enzyme
(ACE2)
is
expressed
in
various
organs,
such
lungs,
intestine,
heart,
esophagus,
kidneys,
bladder,
testis,
liver,
brain.
Different
mechanisms,
particular,
massive
virus
replication,
extensive
apoptosis
necrosis
of
lung-related
epithelial
endothelial
cells,
vascular
leakage,
hyper-inflammatory
responses,
overproduction
pro-inflammatory
mediators,
cytokine
storm,
oxidative
stress,
downregulation
ACE2,
impairment
renin-angiotensin
system
contribute
COVID-19
pathogenesis.
Currently,
a
global
pandemic
with
no
specific
anti-viral
treatment.
The
favorable
capabilities
ginger
were
indicated
patients
suffering
from
osteoarthritis,
neurodegenerative
disorders,
rheumatoid
arthritis,
type
diabetes,
distress,
liver
diseases
primary
dysmenorrheal.
Ginger
or
compounds
exhibited
strong
anti-inflammatory
anti-oxidative
influences
numerous
animal
models.
This
review
provides
evidence
regarding
potential
effects
against
SARS-CoV-2
infection
highlights
antiviral,
anti-inflammatory,
antioxidative,
immunomodulatory
impacts
an
attempt
consider
this
plant
alternative
therapeutic
agent
for
