The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury DOI Creative Commons
Ping Zhou, Shun Zhang,

Maohua Wang

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(5), P. 820 - 820

Published: May 11, 2023

Cell death includes programmed and nonprogrammed cell death. The former mainly ferroptosis, necroptosis, pyroptosis, autophagy, apoptosis, while the latter refers to necrosis. Accumulating evidence shows that pyroptosis play essential regulatory roles in development of intestinal diseases. In recent years, incidence inflammatory bowel disease (IBD), colorectal cancer (CRC), injury induced by ischemia-reperfusion (I/R), sepsis, radiation have gradually increased, posing a significant threat human health. advancement targeted therapies for diseases based on provides new strategies treating Herein, we review with respect regulation highlight underlying molecular mechanisms potential therapeutic applications.

Language: Английский

Ferroptosis in infection, inflammation, and immunity DOI Creative Commons
Xin Chen, Rui Kang, Guido Kroemer

et al.

The Journal of Experimental Medicine, Journal Year: 2021, Volume and Issue: 218(6)

Published: May 12, 2021

Ferroptosis is a type of regulated necrosis that triggered by combination iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers ferroptosis can be divided into two categories (biological versus chemical) activate major pathways (the extrinsic/transporter the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death implicated in growing list physiological pathophysiological processes, coupled to dysregulated immune response. This review focuses on new discoveries related how cells their spilled contents shape innate adaptive immunity health disease. Understanding immunological characteristics activity not only illuminates an intersection between but may also lead development novel treatment approaches for immunopathological diseases.

Language: Английский

Citations

541
Targeting ferroptosis opens new avenues for the development of novel therapeutics DOI Creative Commons

Shumin Sun,

Jie Shen, Jianwei Jiang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 21, 2023

Abstract Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types, neurodegenerative disease, involving tissue and/or organ injury, inflammatory infectious diseases. Although precise regulatory networks underlie are largely unknown, particularly respect to initiation progression diseases, recognized bona fide target for further development treatment prevention strategies. Over past decade, considerable progress has been made developing pharmacological agonists antagonists these ferroptosis-related conditions. Here, we provide detailed overview our current knowledge regarding ferroptosis, its pathological roles, regulation during disease progression. Focusing on use chemical tools preclinical studies, also summarize recent advances targeting across growing spectrum ferroptosis-associated Finally, discuss new challenges opportunities potential strategy treating

Language: Английский

Citations

235
The emerging role of ferroptosis in intestinal disease DOI Creative Commons

Shu Xu,

Yao He, Lihui Lin

et al.

Cell Death and Disease, Journal Year: 2021, Volume and Issue: 12(4)

Published: March 17, 2021

Ferroptosis is a newly recognised type of regulated cell death (RCD) characterised by iron-dependent accumulation lipid peroxidation. It significantly distinct from other RCDs at the morphological, biochemical, and genetic levels. Recent reports have implicated ferroptosis in multiple diseases, including neurological disorders, kidney injury, liver cancer. Ferroptotic has also been associated with dysfunction intestinal epithelium, which contributes to several diseases. Research on may provide new understanding disease pathogenesis that benefits clinical treatment. In this review, we an overview its underlying mechanisms, then describe emerging role ischaemia/reperfusion (I/R) inflammatory bowel (IBD), colorectal cancer (CRC).

Language: Английский

Citations

182
Molecular mechanisms of ferroptosis and relevance to inflammation DOI Open Access

Liyan Deng,

Shasha He,

Nuoqing Guo

et al.

Inflammation Research, Journal Year: 2022, Volume and Issue: 72(2), P. 281 - 299

Published: Dec. 19, 2022

Language: Английский

Citations

139
Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota DOI
Yi Wu,

Lei Ran,

Yue Yang

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 314, P. 121312 - 121312

Published: Dec. 21, 2022

Language: Английский

Citations

126
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway DOI
Yanjun Chen, Jiayu Wang, Juntao Li

et al.

European Journal of Pharmacology, Journal Year: 2021, Volume and Issue: 911, P. 174518 - 174518

Published: Sept. 23, 2021

Language: Английский

Citations

121
Ferroptosis in health and disease DOI Creative Commons
Carsten Berndt, Hamed Alborzinia,

Vera Skafar Amen

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103211 - 103211

Published: May 30, 2024

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark ferroptosis uncontrolled overwhelming peroxidation polyunsaturated fatty acids contained membrane phospholipids, which eventually leads to rupture the plasma membrane. unique that it essentially spontaneous, uncatalyzed chemical process based on perturbed iron redox homeostasis contributing process, but nonetheless modulated by many metabolic nodes impinge cells' susceptibility ferroptosis. Among affecting sensitivity, several have emerged as promising candidates for pharmacological intervention, rendering ferroptosis-related proteins attractive targets treatment numerous currently incurable diseases. Herein, current members Germany-wide research consortium focusing research, well key external experts who made seminal contributions this rapidly growing exciting field gathered provide comprehensive, state-of-the-art review Specific topics include: basic mechanisms, vivo relevance, specialized methodologies, tools, potential contribution disease etiopathology progression. We hope article will not only established scientists newcomers with an overview multiple facets ferroptosis, also encourage additional efforts characterize further molecular pathways modulating ultimate goal develop novel pharmacotherapies tackle associated - or caused

Language: Английский

Citations

75
The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

et al.

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

Citations

64
The Mechanisms of Ferroptosis Under Hypoxia DOI Creative Commons
Xīn Gào, Wei Hu, Dianlun Qian

et al.

Cellular and Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 43(7), P. 3329 - 3341

Published: July 17, 2023

Abstract Ferroptosis is a new form of programmed cell death, which characterized by the iron-dependent accumulation lipid peroxidation and increase ROS, resulting in oxidative stress death. Iron, lipid, multiple signaling pathways precisely control occurrence implementation ferroptosis. The mainly include Nrf2/HO-1 pathway, p62/Keap1/Nrf2 pathway. Activating pathway inhibits promotes Furthermore, some factors also participate ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, related with hypoxia-related diseases, MIRI, cancers, AKI. Accordingly, appears to be therapeutic target for diseases.

Language: Английский

Citations

62
Ferroptosis in ulcerative colitis: Potential mechanisms and promising therapeutic targets DOI Open Access

Dan Long,

Chenhan Mao,

Yingtao Huang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722

Published: May 9, 2024

Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.

Language: Английский

Citations

17