Physiological Research,
Journal Year:
2023,
Volume and Issue:
72(3)
Published: June 30, 2023
Reactive
oxygen
species
(ROS)
are
small
reactive
molecules
produced
by
cellular
metabolism
and
regulate
various
physiological
pathological
functions.
Many
studies
have
shown
that
ROS
plays
an
essential
role
in
the
proliferation
inhibition
of
tumor
cells.
Different
concentrations
can
a
“double-edged
sword”
effect
on
occurrence
development
tumors.
A
certain
concentration
activate
growth-promoting
signals,
enhance
invasion
cells,
cause
damage
to
biomacromolecules
such
as
proteins
nucleic
acids.
However,
body's
antitumor
signal
at
higher
levels
initiating
oxidative
stress-induced
apoptosis
autophagy
This
review
analyzes
ROS's
unique
bidirectional
regulation
mechanism
focusing
key
signaling
pathways
regulatory
factors
affect
tumors
providing
ideas
for
in-depth
understanding
action
its
clinical
application.
Foods,
Journal Year:
2022,
Volume and Issue:
11(6), P. 800 - 800
Published: March 10, 2022
This
study
aimed
to
characterize
the
structure
of
Chinese
yam
(Dioscoreae
Rhizoma)
polysaccharide
(CYP)
and
investigate
its
protective
effect
against
H2O2-induced
oxidative
damage
in
IEC-6
cells.
The
chemical
composition
structural
characteristics
samples
were
analyzed
by
instrumental
methods,
including
high-performance
gel
permeation
chromatography,
anion-exchange
chromatography
(HPAEC),
Fourier
transformed
infrared
(FT-IR),
ultraviolet
(UV),
scanning
electron
microscopy
(SEM).
Antioxidant
activity
was
evaluated
establishing
a
cellular
model
damage.
molecular
weight
CYP
20.89
kDa.
Analysis
monosaccharide
revealed
that
primarily
comprised
galactose
(Gal),
glucose
(Glu),
galacturonic
acid
(GalA),
ratio
between
them
28.57:11.28:37.59.
Pretreatment
with
able
improve
cell
viability,
superoxide
dismutase
(SOD)
activity,
reduce
intracellular
reactive
oxygen
species
(ROS)
production
malondialdehyde
(MDA)
content
after
H2O2
injury.
also
attenuated
cells
through
mitogen-activated
protein
kinase
(MAPK)
signaling
pathway.
showed
an
acidic
heteropolysaccharide
good
damage,
it
thus
has
prospects
food
biopharmaceutical
industries.
Inorganic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1639 - 1667
Published: Jan. 1, 2024
Oxaliplatin(
iv
)
prodrugs,
classified
by
the
role
of
their
axial
ligands,
are
presented
with
a
focus
on
in
vitro
stability
and
activity
vivo
models,
illustrating
potential
to
address
current
Pt-based
chemotherapy's
main
limitations.
Physiological Research,
Journal Year:
2023,
Volume and Issue:
72(3)
Published: June 30, 2023
Reactive
oxygen
species
(ROS)
are
small
reactive
molecules
produced
by
cellular
metabolism
and
regulate
various
physiological
pathological
functions.
Many
studies
have
shown
that
ROS
plays
an
essential
role
in
the
proliferation
inhibition
of
tumor
cells.
Different
concentrations
can
a
“double-edged
sword”
effect
on
occurrence
development
tumors.
A
certain
concentration
activate
growth-promoting
signals,
enhance
invasion
cells,
cause
damage
to
biomacromolecules
such
as
proteins
nucleic
acids.
However,
body's
antitumor
signal
at
higher
levels
initiating
oxidative
stress-induced
apoptosis
autophagy
This
review
analyzes
ROS's
unique
bidirectional
regulation
mechanism
focusing
key
signaling
pathways
regulatory
factors
affect
tumors
providing
ideas
for
in-depth
understanding
action
its
clinical
application.
