Angiotensin‐converting enzyme inhibitors attenuate circulating CAF22 and physical decline in congestive heart failure: Diagnostic implications of CAF22

British Journal of Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Aims Age‐associated muscle loss, termed sarcopenia is the major cause of physical disability in patients with congestive heart failure (CHF). Angiotensin‐converting enzyme inhibitors (ACEi) are commonly used to treat CHF patients; however, their impacts on neuromuscular junction (NMJ) and remain poorly understood. We aim investigate potential impact ACEi NMJ CHF‐induced sarcopenia. Methods The cardiac function, short performance battery, handgrip strength (HGS), appendicular skeletal mass index, gait speed (GS) plasma c‐terminal agrin fragment‐22 (CAF22), a marker degradation, were assessed controls ( n = 81) treated 134) or without 145) ACEi. Results Irrespective treatment, HGS GS, indicators sarcopenia, profoundly declined vs . controls. However, demonstrated significantly better GS compared non‐ACEi P < .001). level CAF22 was lower .0001) ACEi‐treated patients. Further, inversely correlated R 2 .33, both patients, while battery only but not other therapies receiver operating characteristic curve analysis revealed as diagnostic (95% confidence interval: 0.785–0.883; for CHF. Conclusion Collectively, these findings strongly suggest that limits disjunction has shown implications

Language: Английский

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The Importance of Diaphragmatic Function in Neuromuscular Expression in Patients With Chronic Heart Failure

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 4, 2023

Chronic heart failure (CHF) is a set of symptoms and physical manifestations caused by the inability to perform its normal contractile function satisfy blood needs all organs. This dysfunction leads non-physiological adaptation body systems, including skeletal muscles diaphragm. The myopathy found in patients brings such as fatigue intolerance exercise, with an entity not always attributable cardiac function. Neuromuscular incoordination one related CHF, causing increased risk mortality hospitalization. article reviews diaphragmatic presence CHF seeks emphasize importance diaphragm understanding muscle patients.

Language: Английский

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Role of Intestinal Inflammation and Permeability in Patients with Acute Heart Failure

Medicina, Journal Year: 2023, Volume and Issue: 60(1), P. 8 - 8

Published: Dec. 20, 2023

Background and Objectives: Heart failure (HF) represents a major health burden. Although several treatment regimens are available, their effectiveness is often unsatisfactory. Growing evidence suggests pivotal role of the gut in HF. Our study evaluated prognostic intestinal inflammation permeability older patients with acute HF (AHF), correlation common parameters traditionally used diagnostic-therapeutic management Materials Methods: In single-center observational, prospective, longitudinal study, we enrolled 59 admitted to Emergency Department (ED) then hospitalized diagnosis AHF, from April 2022 2023. Serum routine laboratory transthoracic echocardiogram were assayed within first 48 h ED admission. Fecal calprotectin (FC) both serum fecal levels zonulin measured, respectively, as markers permeability. The combined clinical outcome included rehospitalizations for AHF and/or death 90 days. Results: Patients increased FC values (>50 µg/g) showed significantly worse outcomes (p < 0.001) higher median NT-proBNP 0.05). No significant was found between outcome. Median TAPSE lower those After multivariate analysis, > 50 µg/g resulted independent predictors Conclusions: preliminary finding supports hypothesis close relationship heart, recognizing specific marker such FC, an predictive AHF. Further studies needed confirm these results, well investigate reliability new strategies targeted at modulation inflammatory response, which able impact course diseases, mainly frail patients.

Language: Английский

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Association of neuromuscular disjunction with cachexia in patients with gynecological cancers

Archives of Gerontology and Geriatrics Plus, Journal Year: 2024, Volume and Issue: 1(3), P. 100034 - 100034

Published: May 7, 2024

The potential contributions of neuromuscular junction (NMJ) degradation to muscle loss in cancer remain poorly understood. We investigated the biomarkers NMJ decline patients with gynecological carcinomas. recruited women endometrial (n=37, 56-73 years old) or ovarian (n=40, 55-72 carcinomas along age-matched controls (n=47, 55-71 controls, divided into two subgroups based on presence age-associated loss, termed sarcopenia. measured plasma c-terminal agrin-fragment-32 (CAF22; biomarker loss), neurofilament light chain (NF-L; neurodegeneration), handgrip strength (HGS), appendicular skeletal mass index (AMMI), and short physical performance battery (SPPB; marker capacity). Patients exhibits low HGS, AMMI, SPPB higher NF-L levels than (all p<0.05). found a modest elevation CAF22 but not sarcopenia was associated further levels. Higher carcinoma stages were both groups patients. Collectively, may have contribution strategies counter target intrinsic changes within independent NMJ.

Language: Английский

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Intestinal permeability in human cardiovascular diseases: a systematic review and meta-analysis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 17, 2024

There is a link between cardiovascular diseases and intestinal permeability, but it not clear. This review aimed to elucidate permeability in by meta-analysis.

Language: Английский

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