A Comprehensive Overview of Organ Inflammatory Responses: Genesis, Possible Mechanisms, and Mediators of Inflammation

Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 29(4), P. 397 - 416

Published: July 15, 2023

An immune system response known as inflammation can be carried on by a variety of things, such infections, damaged cells, and noxious substances. These factors may cause acute or chronic inflammatory responses in the heart, pancreas, liver, kidney, lungs, brain, colon, reproductive system, which disease tissue damage. Inflammatory cells signaling pathways are activated both pathogenic non-pathogenic agents, cell injury, infectious agents. The most ubiquitous types these include tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), High mobility group box 1 protein (HMGB1), mitogen-activated kinase (MAPK), monocyte chemoattractant (MCP1), interleukin beta (IL1β), Janus kinase-signal transducer activator transcription (JAK-STAT). Severe has potential to systemic syndrome. severe forms this condition characterized hyperinflammation organ damage, shock, even death. We concentrate origin inflammation, all conceivable mechanisms, organ-specific study reactions inside organs.

Language: Английский

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Exploring the Function of Inflammatory Routes in Insulin Resistance: Interpreting the Inflammatory Veil of Medusa

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: June 24, 2024

A common component of metabolic diseases including syndrome and type 2 diabetes, insulin resistance is now known to be closely linked persistent low-grade inflammation. This chapter explores the intricate connection between inflammatory pathways, clarifying molecular processes that underlie inflammation-induced resistance. We examine part important mediators play in upsetting signalling pathways encouraging resistance, cytokines, chemokines, adipokines. also go over how cascades, like JNK NF-κB affect sensitivity cellular metabolism. Understanding interaction inflammation can help better understand pathogenesis identify possible treatment targets. In people who are at risk developing issues associated with strategies targeted reducing responses may able reduce enhance health.

Language: Английский

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Cadmium exposure elicited dynamic RNA m6A modification and epi-transcriptomic regulation in the Pacific whiteleg shrimp Litopenaeus vannamei

Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Journal Year: 2024, Volume and Issue: 52, P. 101307 - 101307

Published: Aug. 6, 2024

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“NO” controversy?: A controversial role in insulin signaling of diabetic encephalopathy

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 593, P. 112346 - 112346

Published: Aug. 14, 2024

Language: Английский

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