Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100910 - 100910
Published: April 13, 2024
The
early
diagnosis
of
cancer
is
vital
for
effective
treatment
and
improved
prognosis.
Tumor
biomarkers,
which
can
be
used
the
diagnosis,
treatment,
prognostic
evaluation
cancer,
have
emerged
as
a
topic
intense
research
interest
in
recent
years.
Nucleic
acid,
type
tumor
biomarker,
contains
genetic
information,
great
significance
occurrence
development
cancer.
Currently,
living
cell
nucleic
acid
probes,
enable
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 4, 2025
Introduction:
Gastric
cancer
(GC)
exhibits
high
invasiveness,
delayed
diagnosis,
and
poor
prognosis.
Chronic
atrophic
gastritis
(CAG),
an
initial
stage
within
the
Correa
cascade,
induces
gastric
mucosal
inflammation
atrophy,
promoting
genetic
epigenetic
alterations.
MicroRNAs
(miRNAs)
dysregulation
has
been
implicated
in
tumorigenesis,
yet
their
specific
roles
CAG
progression
to
GC
remain
unclear.
Methods:
Using
clinical
data
from
GEO
database,
we
identified
miRNAs
differentially
expressed
mucosa
serum
samples
patients.
Murine
models
were
established
through
administration
of
N-methyl-N-nitrosourea
(MNU)
high-salt
diet
(HSD).
In
vitro
functional
assays
evaluated
proliferation
migration
after
miRNA
modulation
cell
lines.
MiRNA
target
validation
involved
luciferase
reporter
assays.
Results:
MiR-3613-5p
expression
was
significantly
elevated
patients,
tissues
tumor
tissues,
human
demonstrated
increased
miR-3613-5p
following
MNU
HSD-induced
CAG.
Functionally,
overexpression
promoted
vitro,
whereas
silencing
alleviated
pathological
alterations
(atrophy,
hyperplasia,
inflammatory
infiltration)
vivo.
Mechanistically,
inhibited
Aquaporin
4
(AQP4)
by
directly
targeting
its
3'UTR.
Discussion:
Our
findings
provide
first
evidence
that
facilitates
toward
via
negative
regulation
AQP4.
These
results
highlight
as
a
promising
biomarker
therapeutic
target,
suggesting
antagomiR-3613-5p
potential
novel
strategy
prevent
carcinogenesis.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Cancer
remains
a
significant
global
health
challenge,
with
its
progression
driven
by
both
genetic
mutations
and
reversible
epigenetic
modifications.
This
review
highlights
the
potential
of
phytochemicals
to
modulate
mechanisms
for
cancer
prevention
treatment.
Natural
compounds
such
as
quercetin,
EGCG,
genistein,
β-elemene
interact
key
processes
DNA
methylation,
histone
modifications,
non-coding
RNA
regulation.
These
enable
reactivation
tumor
suppressor
genes,
increased
sensitivity
conventional
therapy
mitigation
drug
resistance.
For
instance,
EGCG
improves
efficacy
cisplatin
altering
methylation
patterns,
while
genistein
influences
breast
through
HER2
pathway
However,
challenges
low
bioavailability,
variability
in
compound
composition,
need
robust
clinical
validation
remain.
Further
high-quality
trials
are
required
confirm
safety
these
therapy.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100910 - 100910
Published: April 13, 2024
The
early
diagnosis
of
cancer
is
vital
for
effective
treatment
and
improved
prognosis.
Tumor
biomarkers,
which
can
be
used
the
diagnosis,
treatment,
prognostic
evaluation
cancer,
have
emerged
as
a
topic
intense
research
interest
in
recent
years.
Nucleic
acid,
type
tumor
biomarker,
contains
genetic
information,
great
significance
occurrence
development
cancer.
Currently,
living
cell
nucleic
acid
probes,
enable
