BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 15, 2024
Parkinson's disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship between renal function and the risk of PD remains poorly understood. This study aims to explore association kidney developing PD.
Language: Английский
Blood Purification, Journal Year: 2024, Volume and Issue: 53(10), P. 824 - 837
Published: Aug. 7, 2024
Introduction: Uremic patients exhibit remarkably increased rates of mortality and cardiovascular (CV) events, but risk prediction in this setting remains difficult. Systemic mitochondrial dysfunction is pervasive end-stage kidney disease may contribute to CV complications. We tested the clinical significance circulating MOTS-c, a small mitochondrial-derived peptide, as biomarker for improving hemodialysis (HD) patients. Methods: conducted prospective, observational, multicenter study on 94 prevalent HD The endpoint was composite all-cause non-fatal events. diagnostic prognostic capacities predictive models based cohort-related factors were before after inclusion MOTS-c. Results: MOTS-c levels higher than controls (p < 0.001) even more elevated = 0.01) 53 individuals experiencing combined during follow-up (median duration: 26.5 months). independently associated with at either multivariate logistic (OR 1.020; 95% CI: 1.011–1.109; p 0.03) or Cox regression analyses (HR 1.004; 1.000–1.025; 0.05) addition including other predictors (age, left ventricular mass, evidence diastolic dysfunction, diabetes, pulse pressure) significantly improved calibration, variability explanation, discrimination (receiver operating characteristic area under curve from 0.727 0.743; C-index 0.658 0.700), particularly, overall reclassification capacity (NRI 15.87%; 0.01). Conclusions: In patients, peptide impart significant information refine prediction, beyond factors. Future investigations are needed generalize these findings larger heterogeneous cohorts.
Language: Английский
Citations
2
Urolithiasis, Journal Year: 2024, Volume and Issue: 52(1)
Published: Aug. 13, 2024
Language: Английский
Citations
2
Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111450 - 111450
Published: Oct. 11, 2024
Language: Английский
Citations
2
Mitochondrial Communications, Journal Year: 2024, Volume and Issue: 2, P. 21 - 37
Published: Jan. 1, 2024
Kidney diseases are a growing health problem worldwide, causing millions of deaths. Acute kidney injury (AKI) commonly evolves into chronic disease (CKD) and fibrosis, which is feature CKD predisposing to end-stage renal disease. Thus, treatments that avoid this transition urgently necessary. Mitochondria the hub energy house cells, provides in adenosine triphosphate (ATP) form, obtained from β-oxidation through fatty acids degradation mitochondrial matrix. plastic organelles constantly change according cell's requirements. For this, mitochondria carry out biogenesis, fission, fusion, mitophagy/autophagy, processes highly regulated maintain bioenergetics homeostasis. Alterations one or more these might cause detrimental consequences affect cell function. In sense, it widely accepted dysfunction associated with oxidative stress plays crucial role developing diseases. Therefore, antioxidants target be an excellent strategy ameliorate dysfunction, selecting another antioxidant could depend on AKI This review focuses potent such as sulforaphane (SFN), N-acetyl cysteine (NAC), resveratrol, curcumin, quercetin, α-mangostin improvement function pathologies.
Language: Английский
Citations
1
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 15, 2024
Parkinson's disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship between renal function and the risk of PD remains poorly understood. This study aims to explore association kidney developing PD.
Language: Английский
Citations
1