Causal association of inflammatory bowel disease with sarcoidosis and the mediating role of primary biliary cholangitis DOI Creative Commons

Jiazhi Yi,

Shuyun Wu,

Hongxia He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Objectives Previous observational epidemiological studies have identified a potential association between inflammatory bowel disease (IBD) and sarcoidosis. Nonetheless, the precise biological mechanisms underlying this remain unclear. Therefore, we adopted Mendelian randomization (MR) approach to investigate causal relationship IBD with genetic susceptibility sarcoidosis, as well explore mediating role. Methods The associations were obtained from publicly available genome-wide (GWASs) of European ancestry. dataset has 31,665 cases 33,977 controls, consisting 13,768 individuals ulcerative colitis (UC) 17,897 Crohn’s (CD). sarcoidosis 4,854 446,523 controls. A bidirectional causality was implemented be determined by two-sample MR approach. inverse variance weighted (IVW) method utilized main statistical method, series sensitivity analyses performed detect heterogeneity horizontal pleiotropy. two-step used whether pathway mediated PBC. Results forward analysis indicated that predisposition significantly linked an increased risk (OR = 1.088, 95% CI: 1.023–1.158, p IBD-sar 7.498e-03). Similar observed in CD 1.082, 1.028–1.138, CD-sar 2.397e-03) UC 1.079, 1.006–1.158, UC-sar 0.034). Reverse revealed correlated augmented 1.306, 1.110–1.537, sar-CD 1.290e-03) but not or UC. mediation via showed influence on effects partly PBC, effect 0.018 (95% 0.005–0.031, 7.596e-03) proportion 21.397% IBD, 0.014 0.004–0.024, 7.800e-03) 17.737% CD. Conclusions provided evidence substantiating (CD UC) PBC playing role However, only enhances developing CD, These findings illuminate etiology contribute management patients.

Language: Английский

Combination of Youhua Kuijie Prescription and sulfasalazine can alleviate experimental colitis via IL-6/JAK2/STAT3 pathway DOI Creative Commons
Lili Tang,

Yuedong Liu,

Hongwu Tao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 10, 2024

Youhua Kuijie prescription (YHKJ) is a hospital preparation that composed of nine kinds herbs. Sulfasalazine (SASP) widely used as first-line clinical treatment for UC. Traditional Chinese medicine and Western have their own advantages in the UC, mechanism YHKJ combined with SASP UC needs to be investigated.

Language: Английский

Citations

1
Mixed Th1/Th2/Th17 Responses Induced by Plant Oil Adjuvant-Based B. bronchiseptica Vaccine in Mice, with Mechanisms Unraveled by RNA-Seq, 16S rRNA and Metabolomics DOI Creative Commons

Xuemei Cui,

Qiuyu Xiang,

Yee Huang

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1182 - 1182

Published: Oct. 17, 2024

Background/Objectives: The current Bordetella bronchiseptica (Bb) vaccine, when adjuvanted with alum, does not elicit adequate robust cellular immunity or effective antibody defense against Bb attacks. Unfortunately, antibiotic treatment generally represents an ineffective strategy due to the development of resistance a broad range antibiotics. Methods: present study was designed investigate immune response, protective capabilities and underlying mechanisms plant oil-based adjuvant E515 formulated inactivated antigen as potential vaccine candidate bronchiseptica. Results: Immunization studies revealed that combination SO, VE GS (E515) exhibited good synergistic effect. proven be highly efficacious induced mixed Th1/Th2/Th17 response in mice, leading significant increase Bb-specific IgG, IgG1 IgG2a antibodies, proliferative lymphocyte responses cytokine levels (by lymphocytes serum) effectively by CD4+ TE, TM cells B cells. significantly enhanced protection provided mice model, indicated reduced bacterial burden lungs. Multi-omics sequencing analysis functions modulating critical pathways, including cytokine–cytokine receptor interaction, IL-17 signaling pathway chemokine pathway. This modulation also included interactions beneficial species bacteria Alistipes, Odoribacter Colidextribacter, well energy lipid-related metabolites, thus highlighting its role immunomodulatory agent. Conclusion: Collectively, our results demonstrate huge E515-Bb candidates, vegetable oil original promising agent for new veterinary vaccines.

Language: Английский

Citations

1
Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment DOI Creative Commons
Samantha Hsieh,

Arun Chandnani,

Siyan Cao

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2910 - 2910

Published: Dec. 20, 2024

Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles bile acids (BAs) play in IBD may lead to development of novel treatments independent direct immunosuppression. This review discusses latest discoveries BAs pathogenesis explores how these offer promising therapeutic targets treat improve patient outcomes. Several discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, mesenchymal stem cell have all been shown decrease activity.

Language: Английский

Citations

1
Harnessing nature’s pharmacy: investigating natural compounds as novel therapeutics for ulcerative colitis DOI Creative Commons
You Huang, Qiuhong Wu, Sha Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 14, 2024

Backgrounds Ulcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research development new drugs for treatment are urgent, natural compounds an important source. However, there lack systematic summarization their mechanisms UC. Methods We reviewed literature in databases below from inception until July 2023: Web Science, PubMed, China National Knowledge Infrastructure, Wanfang Data, obtain information on relationship between Results results showed that 279 treat through four main mechanisms, including regulating gut microbiota metabolites (Mechanism I), protecting intestinal mucosal barrier II), immune response III), as well other Ⅳ) such cellular autophagy modulation ferroptosis inhibition. Of these, Mechanism III regulated by all compounds. compounds, 62 terpenoids, 57 alkaloids, 52 flavonoids, 26 phenols, 19 phenylpropanoids, 9 steroids, saponins, 8 quinonoids, 6 vitamins, 31 others, can effectively ameliorate flavonoids have greatest potential treating It noteworthy highlight total 54 exhibit therapeutic effects modulating Mechanisms I, II, III. Conclusion This review serves comprehensive resource pharmaceutical industry, researchers, clinicians seeking novel approaches combat Harnessing these may significantly contribute improvement quality life patients with promotion disease-modifying therapies future.

Language: Английский

Citations

1
Causal association of inflammatory bowel disease with sarcoidosis and the mediating role of primary biliary cholangitis DOI Creative Commons

Jiazhi Yi,

Shuyun Wu,

Hongxia He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Objectives Previous observational epidemiological studies have identified a potential association between inflammatory bowel disease (IBD) and sarcoidosis. Nonetheless, the precise biological mechanisms underlying this remain unclear. Therefore, we adopted Mendelian randomization (MR) approach to investigate causal relationship IBD with genetic susceptibility sarcoidosis, as well explore mediating role. Methods The associations were obtained from publicly available genome-wide (GWASs) of European ancestry. dataset has 31,665 cases 33,977 controls, consisting 13,768 individuals ulcerative colitis (UC) 17,897 Crohn’s (CD). sarcoidosis 4,854 446,523 controls. A bidirectional causality was implemented be determined by two-sample MR approach. inverse variance weighted (IVW) method utilized main statistical method, series sensitivity analyses performed detect heterogeneity horizontal pleiotropy. two-step used whether pathway mediated PBC. Results forward analysis indicated that predisposition significantly linked an increased risk (OR = 1.088, 95% CI: 1.023–1.158, p IBD-sar 7.498e-03). Similar observed in CD 1.082, 1.028–1.138, CD-sar 2.397e-03) UC 1.079, 1.006–1.158, UC-sar 0.034). Reverse revealed correlated augmented 1.306, 1.110–1.537, sar-CD 1.290e-03) but not or UC. mediation via showed influence on effects partly PBC, effect 0.018 (95% 0.005–0.031, 7.596e-03) proportion 21.397% IBD, 0.014 0.004–0.024, 7.800e-03) 17.737% CD. Conclusions provided evidence substantiating (CD UC) PBC playing role However, only enhances developing CD, These findings illuminate etiology contribute management patients.

Language: Английский

Citations

0