O uso irracional e prolongado de benzodiazepínicos como potenciais causadores de demência em idosos DOI Creative Commons

LARISSA MARCHI,

Luís Fernando Piovesan,

Dallila Brandão dos Santos Bianchi

et al.

Revista Master Ensino Pesquisa e Extensão, Journal Year: 2023, Volume and Issue: 8(16)

Published: Dec. 14, 2023

Introdução: Os benzodiazepínicos são as drogas psiquiátricas mais utilizadas em todo o mundo possuindo propriedades farmacológicas com efeitos sedativos, hipnóticos, ansiolíticos, anticonvulsivantes e relaxantes musculares. No entanto uso prolongado pode estar associado à demência, sobretudo entre os idosos. Objetivo: Investigar a associação demência de Materiais Métodos: Foi feita uma revisão bibliográfica caráter narrativo dos artigos publicados nos últimos dez anos (2013 2023), utilizando bases dados SciELO, PubMed, BVS Google Acadêmico. Resultados: O estudo das bibliografias selecionadas mostrou que idosos tem alta prevalência. Além disso, essa classe medicamentos não é recomendada para por idosos, agravando suas consequências ainda quando tratamento realizado longo prazo, exacerbando série eventos adversos sem apresentar eficácia nesse formato uso. Grande parte estudos fármacoepidemiológicos realizados até momento concluíram usuários apresentam maior risco desenvolver mas permanecem obscuros mecanismos pelos quais possivelmente ocorre aumento do Conclusão: É importante buscar formas menos prejudiciais sanar queixas relação sono ansiedade capacitar profissionais saúde, fim identificar recomendado propor otimizar prescrições. Portanto, há necessidade aprofundados sobre assunto, observar possíveis riscos existentes no irracional benzodiazepínicos.

BDNF/TrkB activators in Parkinson's disease: A new therapeutic strategy DOI Creative Commons

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(10)

Published: May 1, 2024

Parkinson's disease (PD) is a neurodegenerative disorder of the brain and manifested by motor non-motor symptoms because degenerative changes in dopaminergic neurons substantia nigra. PD neuropathology associated with mitochondrial dysfunction, oxidative damage apoptosis. Thus, modulation apoptosis growth factors could be novel boulevard management PD. Brain-derived neurotrophic factor (BDNF) its receptor tropomyosin kinase type B (TrkB) are chiefly involved neuropathology. BDNF promotes survival nigra enhances functional activity striatal neurons. Deficiency TrkB triggers degeneration accumulation α-Syn As well, BDNF/TrkB signalling reduced early phase Targeting specific activators may attenuate this review aimed to discuss potential role against In conclusion, decreased linked severity long-term complications. Activation

Language: Английский

Citations

17
Metformin role in Parkinson’s disease: a double-sword effect DOI
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular and Cellular Biochemistry, Journal Year: 2023, Volume and Issue: 479(4), P. 975 - 991

Published: June 2, 2023

Language: Английский

Citations

41
The beneficial role of autophagy in multiple sclerosis: Yes or No? DOI
Hayder M. Al‐kuraishy, Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 20(2), P. 259 - 274

Published: Sept. 15, 2023

Multiple sclerosis (MS) is a chronic progressive demyelinating disease of the central nervous system (CNS) due to an increase abnormal peripherally auto-reactive T lymphocytes which elicit autoimmunity. The main pathophysiology MS myelin sheath damage by immune cells and defect in generation oligodendrocytes. Macroautophagy/autophagy critical degradation process that eliminates dysfunctional or superfluous cellular components. Autophagy has property double-edged sword it may have both beneficial detrimental effects on neuropathology. Therefore, this review illustrates protective harmful autophagy with regard disease. prevents progression reducing oxidative stress inflammatory disorders. In contrast, over-activated associated neuropathology case use inhibitors alleviate pathogenesis MS. Furthermore, provokes activation different supporting play intricate role functions modulation regulating cell proliferation related demyelination remyelination. enhances remyelination increasing activity oligodendrocytes, astrocytes. However, induces activating microglia cells. conclusion, specific autophagic activators astrocytes, dendritic (DCs), induce against

Language: Английский

Citations

37
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation DOI Open Access

Haydar M. Al‐kuraishy,

Majid S. Jabir,

Ali K. Albuhadily

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

Citations

35
The Molecular Pathway of p75 Neurotrophin Receptor (p75NTR) in Parkinson’s Disease: The Way of New Inroads DOI

Naif H. Ali,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(5), P. 2469 - 2480

Published: Oct. 28, 2023

Language: Английский

Citations

29
Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel DOI
Hayder M. Al‐kuraishy, Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 92, P. 102119 - 102119

Published: Nov. 4, 2023

Language: Английский

Citations

26
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways DOI

Haydar M. Al‐kuraishy,

Majid S. Jabir, Ali I. Al‐Gareeb

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102075 - 102075

Published: Sept. 14, 2023

Language: Английский

Citations

23
Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer’s disease DOI Creative Commons
Rui Mao,

Mengsha Hu,

Xuan Liu

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 22, 2024

Abstract Background Patients with Alzheimer’s disease (AD) are often co-morbid unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD epilepsy, abnormal γ-aminobutyric acid (GABA)ergic transmission is recognized only as a compensative change for glutamatergic damage. Neuregulin 1 (NRG1)-ErbB4 signaling can promote GABA release suppress epileptogenesis, but its effects on cognition still controversial. Methods Four-month-old APPswe/PS1dE9 mice (APP mice) were used animal models the early stage of this study. Acute/chronic chemical-kindling epilepsy established pentylenetetrazol. Electroencephalogram Racine scores performed to assess seizures. Behavioral tests emotion. Electrophysiology, western blot immunofluorescence detect alterations synapses, GABAergic system components NRG1-ErbB4 signaling. Furthermore, NRG1 was administrated intracerebroventricularly into APP then antiepileptic cognitive evaluated. Results had increased susceptibility resulting hippocampal synaptic damage impairment. Electrophysiological analysis revealed decreased hippocampus. This involved reduction number parvalbumin interneurons (PV + Ins) levels synthesis transport. We also found impaired which mediated by PV Ins loss. And administration could effectively reduce seizures improve four-month-old mice. Conclusion Our results indicated that hyperexcitability, further excitation/inhibition imbalance, promoted epileptogenesis AD. Appropriate down-regulate seizure rescue function. study provided potential direction intervening co-morbidity epilepsy.

Language: Английский

Citations

10
Role of fenofibrate in multiple sclerosis DOI Creative Commons
Ahmad Abulaban, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Feb. 9, 2024

Abstract Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of central nervous system (CNS). The underlying pathophysiology MS destruction myelin sheath by immune cells. formation plaques, inflammation, injury neuronal characterizes its neuropathology. plaques are multiple focal regions demyelination disseminated in brain's white matter, spinal cords, deep grey cerebral cortex. Fenofibrate a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates reactions MS. inhibits differentiation Th17 inhibiting expression pro-inflammatory signaling. According to these findings, this review intended illuminate mechanistic immunoinflammatory role fenofibrate mitigating In conclusion, can attenuate neuropathology modulating different pathways, including oxidative stress, autophagy, mitochondrial dysfunction, inflammatory-signaling neuroinflammation.

Language: Английский

Citations

9
Synthesis of novel MOF-on-MOF composite as a magnetic sorbent to dispersive micro solid phase extraction of benzodiazepine drugs prior to determination with HPLC-UV DOI

Mojgan Ojaghzadeh Khalil Abad,

Mahboubeh Masrournia, Ali Javid

et al.

Microchemical Journal, Journal Year: 2023, Volume and Issue: 197, P. 109797 - 109797

Published: Dec. 12, 2023

Language: Английский

Citations

17