A scoping review of preclinical intensive care unit-acquired weakness models DOI Creative Commons

Qingmei Yu,

Jiamei Song,

Luying Yang

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

Background Animal models focusing on neuromuscular outcomes are crucial for understanding the mechanisms of intensive care unit-acquired weakness (ICU-AW) and exploring potential innovative prevention treatment strategies. Aim To analyse evaluate preclinical ICU-AW models. Methods We manually searched five English four Chinese databases from 1 January 2002, to February 2024, reviewed related study references. Full-text publications describing animal muscle atrophy in critical illness were included. Detailed information about model types, species, sex, age, induction methods, outcome measures, drawbacks strengths was extracted each included study. Results A total 3,451 citations initially retrieved, with 84 studies final analysis. The most frequently studied rodents (86.9%), 64.3% which male animals. mostly induced by comprehensive unit (ICU) interventions (38.1%) sepsis (51.2%). Most focused limb muscles (66.7%), diaphragm (21.4%) or both (9.5%). Reported primarily muscular pathological changes (83.3%), electrophysiological examinations (57.1%) grip strength (16.6%). However, details such as mortality data, experimental design, randomisation, blinding, sample size group and/or control inadequately reported. Conclusion Many used ICU-AW, but reporting methodological is often incomplete. Although current ICU can mimic characteristics human there no standard model. Future should develop a enhance reproducibility improve scientific rigor ICU-AW.

Language: Английский

A scoping review of preclinical intensive care unit-acquired weakness models DOI Creative Commons

Qingmei Yu,

Jiamei Song,

Luying Yang

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

Background Animal models focusing on neuromuscular outcomes are crucial for understanding the mechanisms of intensive care unit-acquired weakness (ICU-AW) and exploring potential innovative prevention treatment strategies. Aim To analyse evaluate preclinical ICU-AW models. Methods We manually searched five English four Chinese databases from 1 January 2002, to February 2024, reviewed related study references. Full-text publications describing animal muscle atrophy in critical illness were included. Detailed information about model types, species, sex, age, induction methods, outcome measures, drawbacks strengths was extracted each included study. Results A total 3,451 citations initially retrieved, with 84 studies final analysis. The most frequently studied rodents (86.9%), 64.3% which male animals. mostly induced by comprehensive unit (ICU) interventions (38.1%) sepsis (51.2%). Most focused limb muscles (66.7%), diaphragm (21.4%) or both (9.5%). Reported primarily muscular pathological changes (83.3%), electrophysiological examinations (57.1%) grip strength (16.6%). However, details such as mortality data, experimental design, randomisation, blinding, sample size group and/or control inadequately reported. Conclusion Many used ICU-AW, but reporting methodological is often incomplete. Although current ICU can mimic characteristics human there no standard model. Future should develop a enhance reproducibility improve scientific rigor ICU-AW.

Language: Английский

Citations

0