The
treatment
of
osteoporotic
bone
defect
remains
a
big
clinical
challenge
because
osteoporosis
(OP)
is
associated
with
oxidative
stress
and
high
levels
reactive
oxygen
species
(ROS),
condition
detrimental
for
formation.
Anti-oxidative
nanomaterials
such
as
selenium
nanoparticles
(SeNPs)
have
positive
effect
on
osteogenesis
owing
to
their
pleiotropic
pharmacological
activity
which
can
exert
anti-oxidative
functions
prevent
loss
facilitate
regeneration
in
OP.
In
the
current
study
strategy
one-pot
method
by
introducing
Poly
(lactic
acid-carbonate)
(PDT)
β-Tricalcium
Phosphate
(β-TCP)
SeNPs,
developed
prepare
an
injectable,
anti-collapse,
shape-adaptive
highly
adhesive
artificial
material
(PDT-TCP-SE).
PDT-TCP-SE
exhibits
sufficient
adhesion
biological
microenvironments
good
biocompatibility,
osteogenic
effect,
angiogenic
anti-inflammatory
well
vitro
vivo.
Moreover,
protect
BMSCs
from
erastin-induced
ferroptosis
through
Sirt1/Nrf2/GPX4
antioxidant
pathway,
which,
together,
demonstrated
novel
biomaterial
potential
application
future
defects.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 395 - 395
Published: March 26, 2024
Central
neurological
disorders
are
significant
contributors
to
morbidity,
mortality,
and
long-term
disability
globally
in
modern
society.
These
encompass
neurodegenerative
diseases,
ischemic
brain
traumatic
injury,
epilepsy,
depression,
more.
The
involved
pathogenesis
is
notably
intricate
diverse.
Ferroptosis
neuroinflammation
play
pivotal
roles
elucidating
the
causes
of
cognitive
impairment
stemming
from
these
diseases.
Given
concurrent
occurrence
ferroptosis
due
metabolic
shifts
such
as
iron
ROS,
well
their
critical
central
nervous
disorders,
investigation
into
co-regulatory
mechanism
has
emerged
a
prominent
area
research.
This
paper
delves
mechanisms
along
with
interrelationship.
It
specifically
emphasizes
core
molecules
within
shared
pathways
governing
neuroinflammation,
including
SIRT1,
Nrf2,
NF-κB,
Cox-2,
iNOS/NO·,
how
different
immune
cells
structures
contribute
dysfunction
through
mechanisms.
Researchers’
findings
suggest
that
mutually
promote
each
other
may
represent
key
factors
progression
disorders.
A
deeper
comprehension
common
pathway
between
cellular
holds
promise
for
improving
symptoms
prognosis
related
Journal of Material Science and Technology,
Journal Year:
2024,
Volume and Issue:
211, P. 159 - 170
Published: June 19, 2024
As
a
typical
bioflavonoid,
diosmetin
is
desirable
in
the
field
of
natural
medicine,
healthy
food,
and
cosmetics
by
anti-cancer,
antibacterial,
antioxidant,
estrogen-like
anti-inflammatory
activities,
it
comes
from
wide
range
sources
traditional
Chinese
medicine
like
spider
fragrance,
spearmint
chrysanthemum,
as
well
Citrus
fruit.
However,
analytical
methods
such
silica
gel
column
chromatography
face
multiple
challenges
selective
extraction
biological
materials
medicinal
materials.
Therefore,
urgent
to
develop
new
type
absorbent
with
high
efficiency,
recyclability
good
specificity
diosmetin.
In
this
investigation,
magnetic
surface
molecularly
imprinted
polymer
(labeled
Diosmetin/SMIPs)
was
synthesized
employing
nanoparticles
carrier
4-vinylpyridinyl
(4-VP)
functional
monomer
imprinting
technology.
The
screened
binding
energy
(ΔE)
between
monomers
template
molecules
via
computational
simulation.
Diosmetin/SMIPs
had
level
specific
recognition
adsorption
capability
towards
20.25
mg
g-1
capacity
an
factor
(IF)
2.28.
Additionally,
demonstrated
excellent
regeneration
performance
8
adsorption/desorption
cycles.
addition,
91.20%–94.16%
spiked
recovered
lemon
peel
samples.
strategy
constructing
based
on
simulation
can
effectively
enhance
Meanwhile,
polymerization
showed
anti-interference
reusability,
realized
efficient
targeted
results
investigation
provide
promising
adsorbent
for
enrichment
fruit
complicated
Acta Biomaterialia,
Journal Year:
2024,
Volume and Issue:
180, P. 82 - 103
Published: April 15, 2024
The
treatment
of
osteoporotic
bone
defect
remains
a
big
clinical
challenge
because
osteoporosis
(OP)
is
associated
with
oxidative
stress
and
high
levels
reactive
oxygen
species
(ROS),
condition
detrimental
for
formation.
Anti-oxidative
nanomaterials
such
as
selenium
nanoparticles
(SeNPs)
have
positive
effect
on
osteogenesis
owing
to
their
pleiotropic
pharmacological
activity
which
can
exert
anti-oxidative
functions
prevent
loss
facilitate
regeneration
in
OP.
In
the
current
study
strategy
one-pot
method
by
introducing
Poly
(lactic
acid-carbonate)
(PDT)
β-Tricalcium
Phosphate
(β-TCP)
SeNPs,
developed
prepare
an
injectable,
anti-collapse,
shape-adaptive
adhesive
graft
substitute
material
(PDT-TCP-SE).
PDT-TCP-SE
exhibits
sufficient
adhesion
biological
microenvironments
osteoinductive
activity,
angiogenic
anti-inflammatory
well
vitro
vivo.
Moreover,
protect
BMSCs
from
erastin-induced
ferroptosis
through
Sirt1/Nrf2/GPX4
antioxidant
pathway,
which,
together,
demonstrated
emerging
biomaterial
potential
application
future
defects.
Injectable,
adhesive,
plastic
bioactive
was
successfully
synthesized.
Incorporation
SeNPs
PDT
into
β-TCP
regenerated
new
in-situ
moderating
defects
area.
reduced
ROS
microenvironment.
could
also
moderate
inhibit
via
pathway
vitro.
alleviate
inflammatory
environment
promote
This
has
advantages
simple
synthesis,
biocompatibility,
regulation
level,
value
tissue
engineering.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(3), P. 334 - 334
Published: March 10, 2024
Ferroptosis
is
a
recently
discovered
type
of
programmed
cell
death
that
mechanistically
different
from
other
types
such
as
apoptosis,
necroptosis,
and
autophagy.
It
characterized
by
the
accumulation
intracellular
iron,
overproduction
reactive
oxygen
species,
depletion
glutathione,
extensive
lipid
peroxidation
lipids
in
membrane.
was
ferroptosis
interconnected
with
many
diseases,
neurodegenerative
ischemia/reperfusion
injury,
cancer,
chronic
kidney
disease.
Polyphenols,
plant
secondary
metabolites
known
for
bioactivities,
are
being
extensively
researched
context
their
influence
on
which
resulted
great
number
publications
showing
need
systematic
review.
In
this
review,
an
literature
search
performed.
Databases
(Scopus,
Web
Science,
PubMed,
ScienceDirect,
Springer)
were
searched
time
span
2017
to
November
2023,
using
keyword
“ferroptosis”
alone
combination
“flavonoid”,
“phenolic
acid”,
“stilbene”,
“coumarin”,
“anthraquinone”,
“chalcone”;
after
selection
studies,
we
had
311
papers
143
phenolic
compounds.
total,
53
compounds
showed
ability
induce
ferroptosis,
110
able
inhibit
out
those
compounds,
20
both
abilities
depending
model
system.
The
most
shikonin,
curcumin,
quercetin,
resveratrol,
baicalin.
common
modes
action
modulation
Nrf2/GPX4
Nrf2/HO-1
axis
iron
metabolism.
Foods,
Journal Year:
2024,
Volume and Issue:
13(8), P. 1274 - 1274
Published: April 21, 2024
Yellowhorn
(Xanthoceras
sorbifolium
Bunge)
is
a
unique
oilseed
tree
in
China
with
high
edible
and
medicinal
value.
However,
the
application
potential
of
yellowhorn
has
not
been
adequately
explored.
In
this
study,
widely
targeted
metabolomics
(HPLC-MS/MS
GC-MS)
network
pharmacology
were
applied
to
investigate
nutritional
leaves
flowers.
The
results
suggested
that
leaf
contains
948
non-volatile
metabolites
638
volatile
metabolites,
while
flower
976
636,
respectively.
A
metabolite
analysis
revealed
flowers
contain
variety
functional
components
beneficial
human
body,
such
as
terpenoids,
flavonoids,
alkaloids,
lignans
coumarins,
phenolic
acids,
amino
nucleotides.
An
indicated
combined
action
various
compounds,
2-furanmethanol,
β-icon,
2-methyl-3-furanthiol,
provides
special
flavor
showed
have
wide
range
biological
activities.
This
study
deepens
our
understanding
theoretical
basis
data
support
for
whole
resource
yellowhorn.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1887 - 1898
Published: Feb. 1, 2025
Background:
Cystic
neutrophilic
granulomatous
mastitis
(CNGM)
poses
a
significant
threat
to
the
physical
and
mental
health
of
women
due
its
increasing
incidence,
complex
clinical
manifestations.
Developing
an
appropriate
animal
model
will
help
further
study
pathogenesis
CNGM.
Methods:
Seventy-two
rats
were
randomly
assigned
seven
groups:
group
A
(n=12,
tissue
suspension
0.2mL),
B
1×
10^8
CFU/mL
Corynebacterium
kroppenstedtii
(
CK
)
0.1mL),
C
10^9
D
0.1mL
+
E
F
(n=6,
phosphate
buffer
saline
solution
G
physiological
Complete
Freund's
adjuvant
0.1mL).
Groups
constitute
experimental
groups
with
12
each,
while
served
as
control
6
each.
Tissue
patients
different
concentrations
injected
into
fourth
pair
mammary
glands
rats.
samples
harvested
on
3rd,
7th,
14th
days
post-implantation.
The
breast
specimens
stained
HE
stain
Gram
observe
histopathological
characteristics
presence
Gram-positive
bacteria.
Bacterial
culture
was
performed
.
expression
levels
C-reactive
protein
interleukin-1
beta
detected.
Results:
Rats
in
A,
D,
exhibited
masses
erythema,
some
showing
ulceration,
structures
pathological.
Lipid
vacuoles
rods
observed
E.
Pus
cultures
from
showed
growth
Histopathology
revealed
minimal
inflammatory
cell
infiltration
no
formation
C.
Group
or
infiltration.
presented
without
only
chronic
acute
Levels
significantly
elevated
at
day
14.
Conclusion:
Components
pathological
tissues
patient
combined
suspension,
can
successfully
induce
CNGM
rat
models.
Keywords:
cystic
mastitis,
,
model,
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 7, 2025
Mastitis
is
a
common
inflammation
of
mammary
glands
that
has
significantly
impact
on
dairy
production
and
animal
health,
causing
considerable
economic
burdens
worldwide.
Elevated
reactive
oxygen
species
(ROS)
followed
by
oxidative
stress,
apoptosis,
inflammatory
changes
suppressed
immunity
are
considered
the
key
biomarkers
observed
during
mastitis.
The
Nrf2/KEAP1
signaling
pathway
plays
critical
role
in
regulating
antioxidant
responses
cellular
defense
mechanisms.
When
activated
bioactive
compound
treatment,
Nrf2
translocates
to
nucleus
induces
expression
its
target
genes
exert
responses.
This
reduces
pathogen-induced
stress
inhibiting
NF-kB
glands,
one
prominent
pro-inflammatory
pathway.
Here,
we
summarize
recent
studies
highlight
therapeutic
potential
prevention
treatment
Collectively
this
review
article
aims
explore
compounds
mitigating
mastitis
targeting
