Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Mitochondria
are
essential
double-membrane
organelles
with
intricate
structures
and
diverse
functions
within
cells.
Under
normal
physiological
conditions,
mitochondria
regulate
cellular
metabolism
maintain
energy
homeostasis
via
the
electron
transport
chain,
mediate
stem
cell
fate,
modulate
reactive
oxygen
species
production,
playing
a
pivotal
role
in
supply
lifespan
extension.
However,
mitochondrial
dysfunction
can
lead
to
various
pathological
changes,
including
aging,
necrosis,
dysregulated
tumor
immunity,
initiation
progression
of
cancer.
Moreover,
abnormal
is
closely
associated
numerous
diseases,
such
as
neurodegenerative
disorders,
metabolic
syndromes,
cancers.
In
recent
years,
targeting
has
emerged
promising
anticancer
strategy,
aiming
for
therapeutic
benefits.
Nonetheless,
approaches
face
limitations,
low
delivery
efficiency
insufficient
specificity.
This
review
systematically
explores
structure
function,
their
roles,
potential
challenges
mitochondria-targeted
strategies
cancer
therapy,
providing
insights
future
research
directions.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Abstract
Mitochondria,
known
as
the
powerhouse
of
cell,
are
essential
for
cellular
energy
production.
Dysfunction
in
mitochondrial
function
can
significantly
affect
various
organs.
Transplanting
healthy
mitochondria
enhance
bioenergetics
diseased
cells
and
treat
conditions,
yet
limits
transplantation
still
unknown.
Our
study
reveals
that
source
transplanted
is
not
restricted
by
species,
recipient
show
no
significant
immune
response
to
from
different
lineages.
We
also
found
metabolic
compatibility
between
exogenous
crucial,
transplanting
species
endow
with
distinct
characteristics
combat
diseases.
Furthermore,
our
data
indicate
there
competition
among
varying
functions,
more
powerful
yielding
better
therapeutic
effects.
Notably,
we
have
an
upper
limit
bio-enhancement
provided
mitochondria.
research
proposes
a
feasible
path
human
through
transplantation—adaptive
bio-enhancement.
Mitochondrial
highly
clinically
valuable
technique.
I
further
expanded
variety
sources
demonstrated
potential
adaptively
biological
functions.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(47), P. 32705 - 32722
Published: Nov. 15, 2024
Pulmonary
fibrosis
(PF)
is
an
interstitial
lung
disease
tightly
associated
with
the
disruption
of
mitochondrial
pool
homeostasis,
a
delicate
balance
influenced
by
functional
and
dysfunctional
mitochondria
within
cells.
Mitochondrial
transfer
emerging
technology
to
increase
via
exogenous
delivery;
however,
therapeutic
effect
on
hampered
during
PF
process
persistence
mitochondria,
which
attributed
impaired
mitophagy.
Herein,
we
reported
engineering
Medical Radiology and radiation safety,
Journal Year:
2024,
Volume and Issue:
69(2), P. 12 - 17
Published: April 1, 2024
Radiotherapy
remains
one
of
the
main
methods
cancer
treatment.
At
same
time,
formation
radioresistance
(RR)of
cells
to
ionizing
radiation
leads
a
loss
therapy
effectiveness.
The
toxicity
radiotherapy
is
determined
by
mitochondria,
and
use
mitochondria
or
their
components
in
combination
with
chemo-radio
immunotherapy
can
increase
effectiveness
In
this
review,
we
have
reviewed
new,
experimental
for
using
therapy.
Literature
data
indicate
that
although
physiological
transport
promotes
carcinogenesis
resistance
chemotherapy,
transplantation
exogenous
on
contrary,
induces
radiosensitivity
inhibits
tumor
growth
mouse
models
cancer.
Therefore,
inhibition
endogenous
transfer
development
delivery
promising
area
anti-cancer
drugs.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Background
The
tumor
microenvironment
(TME)
plays
a
pivotal
role
in
supporting
growth
and
metastasis
via
several
inhibitory
mechanisms,
which
diminish
the
effectiveness
of
cancer
immunotherapy.
Central
to
metabolic
reprogramming
tumors,
mitochondria
orchestrate
immunosuppressive
landscape
TME.
Methods
We
extracted
data
spanning
from
1994
2024
Web
Science
Core
Collection
database,
focusing
on
literature
pertinent
this
field.
To
maintain
dataset
consistency,
we
re-evaluated
original
research
articles
compared
them
across
various
types.
Results
study
identified
3,947
publications,
with
comprising
67.29%
(2,656
articles).
overall
trend
publications
increased
2010
onwards,
surge
2020.
Cancers
is
core
journal
most
publications.
Cell
Metabolism
has
total
citations
influential
journal.
Among
individual
contributors,
Zhang
J
highest
number
Vander
Heiden
MG
leads
local
citations.
Key
figures
such
as
Lisanti
MP,
Sotgia
F,
Thompson
CB
are
prominent
authors.
Thomas
Jefferson
University
noted
for
pioneering
sustaining
efforts,
whereas
Fudan
tops
publication
volume.
While
China
quantity,
USA
excels
encompasses
studies
enzymes,
oncogenes,
Warburg
effect,
related
themes.
Conclusion
last
three
years
have
seen
burgeoning
interest
field,
key
areas
gene
expression,
glycolysis,
glutamine
metabolism,
oxidative
phosphorylation
emerging
central
Journal of Pharmaceutical Analysis,
Journal Year:
2024,
Volume and Issue:
15(3), P. 101141 - 101141
Published: Nov. 8, 2024
Mitochondria
play
a
crucial
role
as
organelles,
managing
several
physiological
processes
such
redox
balance,
cell
metabolism,
and
energy
synthesis.
Initially,
the
assumption
was
that
mitochondria
primarily
resided
in
host
cells
could
exclusively
transmit
from
oocytes
to
offspring
by
mechanism
known
vertical
inheritance
of
mitochondria.
Recent
scholarly
works,
however,
suggest
certain
types
their
other
developmental
via
referred
intercellular
or
horizontal
mitochondrial
transfer.
This
review
details
process
which
are
transferred
across
explains
impact
transfer
between
on
efficacy
functionality
cancer
various
forms.
Specifically,
we
regulating
cellular
metabolism
restoration,
excess
reactive
oxygen
species
(ROS)
generation,
proliferation,
invasion,
metastasis,
mitophagy
activation,
DNA
(mtDNA)
inheritance,
immune
system
modulation
therapeutic
resistance
cancer.
Additionally,
highlight
possibility
using
approach
treat
enhance
treatments.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 23, 2024
Mitochondria
are
essential
double-membrane
organelles
with
intricate
structures
and
diverse
functions
within
cells.
Under
normal
physiological
conditions,
mitochondria
regulate
cellular
metabolism
maintain
energy
homeostasis
via
the
electron
transport
chain,
mediate
stem
cell
fate,
modulate
reactive
oxygen
species
production,
playing
a
pivotal
role
in
supply
lifespan
extension.
However,
mitochondrial
dysfunction
can
lead
to
various
pathological
changes,
including
aging,
necrosis,
dysregulated
tumor
immunity,
initiation
progression
of
cancer.
Moreover,
abnormal
is
closely
associated
numerous
diseases,
such
as
neurodegenerative
disorders,
metabolic
syndromes,
cancers.
In
recent
years,
targeting
has
emerged
promising
anticancer
strategy,
aiming
for
therapeutic
benefits.
Nonetheless,
approaches
face
limitations,
low
delivery
efficiency
insufficient
specificity.
This
review
systematically
explores
structure
function,
their
roles,
potential
challenges
mitochondria-targeted
strategies
cancer
therapy,
providing
insights
future
research
directions.
