Psychiatric Annals, Journal Year: 2024, Volume and Issue: 54(8)
Published: Aug. 1, 2024
Language: Английский
npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 22, 2025
An imbalance between oxidative and antioxidant processes in the host can lead to excessive oxidation, a condition known as stress (OS). Although changes hindgut microbiota have been frequently linked OS, specific microbial metabolic underpinnings of this association remain unclear. In study, we enrolled 81 postpartum Holstein cows stratified them into high (HOS, n = 9) low (LOS, groups based on index (OSi). Using multi-omics approach, performed 16S rRNA gene sequencing evaluate diversity, conducted metagenomic analysis identify functional bacteria, utilized untargeted metabolomics profile serum metabolites. Our analyses revealed elevated levels kynurenine, formyl-5-hydroxykynurenamine, 5-hydroxyindole-3-acetic acid LOS dairy cows. Additionally, had higher abundance short-chain fatty acids (SCFAs)-producing including Bacteroidetes bacterium, Paludibacter propionicigenes, Phascolarctobacterium succinatutens (P. succinatutens), which were negatively correlated with OSi. To explore potential role these bacteria mitigating administered P. (108 cfu/day for 14 days) C57BL/6 J mice (n 10). Oral administration significantly increased total capacity, decreased oxidants, reduced OSi mice. Moreover, treatment promoted activation Nrf2-Keap1 pathway, enhancing enzymatic activities GSH-Px SOD, well concentrations acetate propionate colon. conclusion, our findings suggest that systemic tryptophan metabolism disordered SCFAs production are concurrent factors influenced by associated OS development. Modulating microbiota, particularly introducing SCFAs-producing could be promising strategy combating OS.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 122 - 122
Published: Jan. 9, 2025
Alzheimer's disease (AD), the most common form of dementia, is a progressive neurodegenerative disorder that profoundly impacts cognitive function and nervous system. Emerging evidence highlights pivotal roles iron homeostasis dysregulation microbial inflammatory factors in oral gut microbiome as potential contributors to pathogenesis AD. Iron disruption can result excessive intracellular accumulation, promoting generation reactive oxygen species (ROS) oxidative damage. Additionally, agents produced by pathogenic bacteria may enter body via two primary pathways: directly through or indirectly cavity, entering bloodstream reaching brain. This infiltration disrupts cellular homeostasis, induces neuroinflammation, exacerbates AD-related pathology. Addressing these mechanisms personalized treatment strategies target underlying causes AD could play critical role preventing its onset progression.
Language: Английский
Citations
0
Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Porphyromonas gingivalis is one of the major pathogens chronic periodontitis. P. can cause systemic inflammation, amyloid β protein deposition, and hyperphosphorylation tau protein, leading to Alzheimer’s disease (AD)–like lesions. oral infection causes gut microbiota alteration, barrier dysfunction, intestinal immune response inflammation. The microbiota-gut-brain axis has a potential role in pathogenesis AD. Whether affects AD-like lesions via gut-brain needs more study. In this study, orally administered induced alveolar resorption, impairment, Oral with microflora dysbiosis, imbalance tryptophan metabolism pathway microbiota, elevated levels 3-hydroxykynurenine sera hippocampi. key metabolite, 3-hydroxykynurenine, suppressed Bcl2 gene expression, neuronal apoptosis promoting vivo vitro. These findings suggest that induce AD through axis, providing new ideas for prevention treatment
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 17, 2025
Intrinsic capacity is a crucial indicator of adverse outcomes and has predictive value for diseases mortality. The objective this study to assess the association between nighttime sleep duration intrinsic in older Chinese adults. Data were collected from China Health Retirement Longitudinal Study (CHARLS) spanning years 2008–2020. Minimally sufficient adjustment was made confounding factors identified through Directed Acyclic Graphs (DAGs), multivariate logistic regression analysis conducted determine relationship capacity. Restricted cubic splines (RCS) used nonlinear population. Finally, subgroup interaction effect performed. Among 4994 adults, 3118 (62.4%) experienced decline After adjusting factors, associated with an increased risk (P < 0.001), exhibiting J-shaped pattern. For shows nonlinear, dose-response decline. Our provides important insights into health self-management
Language: Английский
Citations
0
The Open Dentistry Journal, Journal Year: 2025, Volume and Issue: 19(1)
Published: April 7, 2025
Background Issues pertaining to oral health have been recognised as a common concern among dementia patients. Past studies indicated several mechanisms through which poor could contribute cognitive decline, such systemic inflammation and direct effects on daily functioning quality of life. Methods An umbrella review was conducted an extensive search across range databases. The strategy combined specific terms that would specifically pick out relevant for decline in dementia. A standardized tool evaluate systematic reviews applied assess the potential bias included. Results We included 8 our investigation, revealed complex relationship between It observed health, characterized by high levels dental plaque, gingival bleeding, periodontal disease, frequently associated with worse outcomes. There were some focused inflammatory process bridge, while others stressed directly influences life performance. Variability severity noted disease its correlation impairment, few studies, protective effect good hygiene reported. Conclusion findings this confirm is indeed individuals This association mediated pathways, inflammation, exacerbates neurodegeneration impacts functioning. Such results underscore need comprehensive care well regular assessments setting people one way preventing deterioration cognition.
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2023, Volume and Issue: 14(1), P. 41 - 41
Published: Dec. 31, 2023
One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity—a complexity that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g., vasculopathy, proteopathy) were multiple factors, dysfunction neuroimmune–neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis
Language: Английский
Citations
7
Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2686 - 2686
Published: Nov. 25, 2024
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiologies, including genetic, environmental, and microbiological factors. In recent years, increasing attention has been given to the role of gut microbiota in ASD. Emerging evidence suggests that dysbiosis may influence central nervous system through gut-brain axis, potentially impacting behavior neurodevelopment. The use 16S rRNA gene sequencing become pivotal tool profiling microbial communities associated ASD, offering valuable insights into bacterial diversity, composition, potential functional roles. This review aims provide comprehensive analysis current findings on relationship between oral particular focus studies utilizing sequencing. We will explore how microbiome alterations contribute ASD pathophysiology, discuss limitations existing research, propose future directions for integration diagnostics treatment strategies. These underscore modulating symptoms. data suggest specific taxa are consistently altered which have implications understanding axis its
Language: Английский
Citations
1
Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(4), P. e72067 - e72067
Published: Aug. 21, 2024
O microbioma oral é composto por uma vasta gama de microrganismos, como bactérias, protozoários, fungos e vírus, que habitam diversos locais na cavidade oral, incluindo a língua, sulco gengival saliva. Esse ecossistema beneficia-se das condições ideais umidade, temperatura pH fornecidas pela boca, além nutrientes abundantes. Cada indivíduo possui um variável, influenciado fatores genéticos ambientais, pode ser alterado idade, dieta, higiene bucal inadequada, tabagismo materiais dentários. A microbiota desempenha funções cruciais, proteção da mucosa, metabolismo modulação imunológica. No entanto, desequilíbrios composição microbiana, conhecidos disbiose, estão associados várias doenças orais sistêmicas Sendo assim, esse artigo explora compreensão dos mecanismos metabólicos bioquímicos regulam equilíbrio, visto importância disso para prevenção tratamento eficaz diversas orais.
Citations
0
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Dec. 9, 2024
In recent years, increasing evidence has highlighted the critical role of myeloid cells, specifically those that present antigen (APCs) in health and disease. These shape progression development neurodegenerative disorders, where considerable interplay between immune system neurons influences course disease pathogenesis. Antigen-presenting cells display different classes major histocompatibility complex (MHC) MHC-like proteins on their surface for presenting various types antigens to a wide variety T cells. While most studies focus MHC class I II molecules disease, there is still much remains unknown about non-polymorphic such as CD1d MR1. Thus, this review, we will summarize findings regarding contributions both classical non-classical molecules, particularly microglial APCs, diseases. This offer better understanding altered mechanisms may pave way novel therapeutic strategies targeting cell-MHC interactions, mitigate neurodegeneration its associated pathology.
Language: Английский
Citations
0
Published: Dec. 6, 2023
One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity – that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review has identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g. vasculopathy) were multiple factors, dysfunction neuroimmune-neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis
Language: Английский
Citations
1