SAL protects endothelial cells from H2O2-induced endothelial dysfunction: Regulation of inflammation and autophagy by EZH2 DOI Creative Commons

Sun Li,

Xuefang Li, Jie Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113060 - 113060

Published: Sept. 24, 2024

Language: Английский

Angiogenesis within Atherosclerotic Plaques: Mechanical Regulation, Molecular Mechanism and Clinical Diagnosis DOI Creative Commons
Hanxiao Chen,

Chih-Yu Peng,

Fei Fang

et al.

Mechanobiology in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100114 - 100114

Published: Feb. 1, 2025

Language: Английский

Citations

1
ECM Microenvironment in Vascular Homeostasis: New Targets for Atherosclerosis DOI
Lu Zhang, Qianqian Feng, Wei Kong

et al.

Physiology, Journal Year: 2024, Volume and Issue: 39(5), P. 324 - 344

Published: July 10, 2024

Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical properties influence both the formation stability of atherosclerotic plaques. This review discusses contribution ECM microenvironment homeostasis remodeling atherosclerosis, highlighting Cartilage oligomeric protein (COMP) its degrading enzyme ADAMTS7 as examples, proposes potential avenues for future research aimed at identifying novel therapeutic targets atherosclerosis based on microenvironment.

Language: Английский

Citations

7
Remodelers of the vascular microenvironment: The effect of biopolymeric hydrogels on vascular diseases DOI
Minhao Li,

Meiqi Jin,

Huazhe Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130764 - 130764

Published: March 9, 2024

Language: Английский

Citations

5
Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies DOI Open Access
Athanasios Chalkias

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17522 - 17522

Published: Dec. 15, 2023

Massive trauma remains a leading cause of death and global public health burden. Post-traumatic coagulopathy may be present even before the onset resuscitation, correlates with severity trauma. Several mechanisms have been proposed to explain development abnormal coagulation processes, but heterogeneity in injuries patient profiles makes it difficult define dominant mechanism. Regardless pattern death, significant role pathophysiology pathogenesis attributed exposure endothelial cells physical forces mechanical stimuli their local environment. In these conditions, cellular responses are translated into biochemical signals that induce/aggravate oxidative stress, inflammation, coagulopathy. Microvascular shear stress-induced alterations could treated or prevented by use innovative pharmacologic strategies effectively target shear-mediated dysfunction, including shear-responsive drug delivery systems novel antioxidants, targeting venous side circulation exploit beneficial antithrombogenic profile cells.

Language: Английский

Citations

12
3D bioprinted biomimetic bilayer GelMA scaffolds for the delivery of BMP-2 and VEGF exogenous growth factors to promote vascularized bone regeneration in a calvarial defect model in vivo DOI
Emıne Alarçın,

Zeynep Püren Akgüner,

Ayça Bal‐Öztürk

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141440 - 141440

Published: Feb. 1, 2025

Language: Английский

Citations

0
Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism DOI
Hao Tan, Shan Wang,

Xinyi He

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

Mechanical force initiates sterile inflammation, a process implicated in diverse physiological and pathological processes. The timely clearance of apoptotic cells by macrophages via efferocytosis is crucial for the proper resolution inflammation averting excessive tissue damage. Despite this, specific role underlying mechanisms mechanical on macrophage remain obscure. By integrating bioinformatics metabolomics analyses, we uncovered how disrupts "arginine metabolism─TCA cycle─mitochondrial function" metabolic cascade, thereby impairing intensifying inflammation. Notably, discovered that elevating l-arginine levels can ameliorate these crises restoring energy metabolism. Leveraging this insight, engineered microneedle drug delivery system loaded with nitric-oxide driven nanomotors (MSN-LA@MNs) targeted l-arginine. active component, MSN-LA, exploits heightened expression inducible nitric oxide synthase (iNOS) force-loaded tissues as chemoattractant, harnessing NO generated from iNOS-catalyzed autonomous propulsion. In force-induced rat orthodontic tooth movement (OTM) model, confirmed MSN-LA@MNs enhance and, under iNOS guidance, dynamically modulate OTM, thus facilitating OTM process. Collectively, our findings elucidate previously unclear mechanistic links between force, efferocytosis, vantage point, offering promising strategy modulating force-related biological processes such OTM.

Language: Английский

Citations

0
Studying biological events using biopolymeric matrices DOI

Joao Aguilar,

Silvana A. Rosú,

Jose L. Ulloa

et al.

Biophysical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
Blood-based HYAL2 methylation as a potential marker for the preclinical detection of coronary heart disease and stroke DOI Creative Commons

Lanfei Bi,

Jialie Jin,

Fan Yao

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 16, 2024

Coronary heart disease (CHD) and stroke have become the leading cause of premature mortality morbidity worldwide. Therefore, sensitive accurate biomarkers for early detection CHD are urgently needed effective prevention treatment. We aim to investigate association between blood-based HYAL2 methylation risk in Chinese population.

Language: Английский

Citations

1
Coronary Spasm Due to Pulsed Field Ablation: A State‐of‐the‐Art Review DOI Creative Commons
David A. Ramirez, Kara Garrott,

Ann C. Garlitski

et al.

Pacing and Clinical Electrophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

ABSTRACT With the ever‐growing population of patients undergoing cardiac ablation with pulsed electric fields, there is a need to understand secondary effects from therapy. Coronary artery spasm one such effect that has recently emerged as subject further investigation in electrophysiology literature. This review aims elucidate basic anatomy underlying vascular due fields and irreversible electroporation on coronary arteries. also gather current preclinical clinical data regarding physiology function arteries following electroporation.

Language: Английский

Citations

1
SAL protects endothelial cells from H2O2-induced endothelial dysfunction: Regulation of inflammation and autophagy by EZH2 DOI Creative Commons

Sun Li,

Xuefang Li, Jie Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113060 - 113060

Published: Sept. 24, 2024

Language: Английский

Citations

0