American Journal of Men s Health,
Journal Year:
2025,
Volume and Issue:
19(2)
Published: March 1, 2025
Physical
activity
is
associated
with
cancer
of
the
male
genitalia.
However,
genetic
causality
this
association
remains
unclear.
In
study,
Mendelian
randomization
(MR)
was
used
to
explore
potential
causal
relationship
between
different
intensities
physical
and
This
study
utilized
single
nucleotide
polymorphisms
(SNPs)
vigorous
exercise
obtained
from
published
genome-wide
studies
(GWAS)
summary
data
genital
GWAS.
The
main
analysis
method
inverse
variance
weighted
(IVW)
for
two-sample
MR
analysis.
heterogeneity
results
assessed
using
Cochran’s
Q
statistic,
while
horizontal
pleiotropy
MR-Egger.
Sensitivity
included
a
“leave-one-out”
test.
showed
that
light
DIY
risk
factor
(OR
=
1.045,
95%
confidence
interval
[1.004,
1.089],
p
.033).
result
passed
sensitivity
found
effect
activities
on
cancer.
Future
should
further
impact
types
specific
improve
relevant
prevention
strategies.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3806 - 3806
Published: April 17, 2025
Pyridazin-3(2H)one-based
molecules
have
always
attracted
the
attention
of
medicinal
chemists
due
to
their
different
pharmacological
properties.
The
incorporation
such
nuclei
in
therapeutically
active
either
as
monocyclic
units
or
fused
bi-
tricyclic
scaffolds
results
a
wide
range
effects
anti-inflammatory,
analgesic,
anticancer,
antimicrobial,
antiviral,
cardiovascular-protective,
antiulcer,
and
many
other
useful
activities.
In
accordance
with
our
consolidated
experience
gained
over
years
chemistry
biology
pyridazin-3(2H)ones,
this
review
summarizes
SAR
studies
pyridazinone-based
polycyclic
compounds
endowed
various
biological
therapeutic
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 18, 2025
Gastroesophageal
reflux
disease
(GERD)
is
increasingly
recognized
for
its
associations
with
extragastric
diseases,
yet
potential
role
in
pancreatic
cancer
(PC)
etiology
remains
underexplored.
This
study
investigates
the
genetic
causal
relationship
between
GERD
and
PC
using
Mendelian
randomization
(MR),
a
method
designed
to
reduce
confounding
factors.
A
two-sample
MR
analysis
was
conducted
genome-wide
association
studies
(GWAS)
data.
The
inverse
variance
weighted
(IVW)
applied,
additional
sensitivity
analyses
performed
evaluate
pleiotropy
heterogeneity.
IVW
demonstrated
significant
signature
predisposing
an
increased
risk
of
(OR:
1.36,
95%
CI:
1.04-1.80,
P
=
0.03).
There
no
evidence
(P
0.71)
or
heterogeneity
0.94).
Our
provides
robust
supporting
that
predisposition
associated
PC.
These
findings
emphasize
necessity
integrating
into
assessments
encourage
further
research
elucidate
underlying
biological
mechanisms.
insight
holds
inform
strategies
early
detection,
prevention,
personalized
management
patients.
American Journal of Men s Health,
Journal Year:
2025,
Volume and Issue:
19(2)
Published: March 1, 2025
Physical
activity
is
associated
with
cancer
of
the
male
genitalia.
However,
genetic
causality
this
association
remains
unclear.
In
study,
Mendelian
randomization
(MR)
was
used
to
explore
potential
causal
relationship
between
different
intensities
physical
and
This
study
utilized
single
nucleotide
polymorphisms
(SNPs)
vigorous
exercise
obtained
from
published
genome-wide
studies
(GWAS)
summary
data
genital
GWAS.
The
main
analysis
method
inverse
variance
weighted
(IVW)
for
two-sample
MR
analysis.
heterogeneity
results
assessed
using
Cochran’s
Q
statistic,
while
horizontal
pleiotropy
MR-Egger.
Sensitivity
included
a
“leave-one-out”
test.
showed
that
light
DIY
risk
factor
(OR
=
1.045,
95%
confidence
interval
[1.004,
1.089],
p
.033).
result
passed
sensitivity
found
effect
activities
on
cancer.
Future
should
further
impact
types
specific
improve
relevant
prevention
strategies.
