Breast milk oligosaccharides are the most essential ingredient in breast milk, affecting the health of infants: A review DOI Creative Commons
И. Н. Захарова, Yana V. Orobinskaya, Narine G. Sugian

et al.

Pediatrics Consilium Medicum, Journal Year: 2024, Volume and Issue: 3, P. 326 - 333

Published: Oct. 10, 2024

Breastfeeding remains the “gold standard” of nutrition for children in first years life. However, factors such as hypogalactia, maternal stress, health problems and simply an unwillingness to breastfeed deprive baby breast milk (BM) challenge pediatricians choose alternative food baby. The BM composition is complex, dynamic, scientific interest, attention most scientists directed oligosaccharides (BMOs). Many benefits BMOs have been proven relation child's health, including formation intestinal microbiota, maturation immune response, contribution barrier function intestine, protection against pathogens. In absence breastfeeding, modern formulas containing can be used. addition a combination 5 promising effective approach maintaining overall formula-fed infants.

Language: Английский

Protective effects and regulatory mechanisms of Platycodin D against LPS-Induced inflammatory injury in BEAS-2B cells DOI
Wei Li,

Yanqing Zhang,

Yuxin Cao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112782 - 112782

Published: July 28, 2024

Language: Английский

Citations

6
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice DOI
Qian Zhao,

Chunyuan Zeng,

Fulan Luo

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Bioactive compounds in human milk DOI
Anthony E. Castro, Maria Sanchez-Holgado, Miguel Sáenz de Pipaón

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

Citations

0
The Jieduan-Niwan Formula Reduces Inflammatory Responses in Acute-on-Chronic Liver Failure Rats by Inhibiting HMGB1-Induced Hepatocyte Pyroptosis DOI Creative Commons
Weixin Hou, Peng Fang, Jiajun Liang

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2503 - 2517

Published: April 1, 2025

Acute-on-chronic liver failure (ACLF) is a global intractable disease. HMGB1-induced hepatocyte pyroptosis expanding inflammatory responses contributes to the pathogenesis of ACLF. The JDNW formula (JDNWF) has significant clinical effect on ACLF, but its hepatoprotective mechanisms remain elusive. To explore potential molecular JDNWF in ACLF by pyroptosis. Rats were divided into normal, Caspase-1 inhibitor, HMGB1 JDNW, JDNW+Caspase-1 inhibitor and JDNW+HMGB1 groups. rat model was established 40% carbon tetrachloride-induced fibrosis, followed intraperitoneal injection D-galactosamine lipopolysaccharide. function, coagulation pathological damage ultrastructural changes hepatocytes evaluated. Triple-immunostaining active Caspase-1, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) albumin performed evaluate percentage pyroptotic hepatocytes. Western blot, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) quantitative real-time PCR (RT-qPCR) used analyze expressions key genes proteins pathways level factors. improved function damage, reduced responses, down-regulated rats. better than those (glycyrrhizin) (VX-765). Compared with glycyrrhizin or VX-765, there no differences above indicators after combination VX-765. These results indicated that inhibited inflammation rats through pathways. protects livers inhibiting reducing suggesting may be therapeutic target

Language: Английский

Citations

0
Quantitative Assessment of Intracellular Effectors and Cellular Response in RAGE Activation DOI Open Access

Vinitha Deepu,

Vikrant Rai,

Devendra K Agrawal

et al.

Archives of Internal Medicine Research, Journal Year: 2024, Volume and Issue: 07(02)

Published: Jan. 1, 2024

The review delves into the methods for quantitative assessment of intracellular effectors and cellular response Receptor Advanced Glycation End products (RAGE), a vital transmembrane receptor involved in range physiological pathological processes. RAGE bind to (AGEs) other ligands, which turn activate diverse downstream signaling pathways that impact responses such as inflammation, oxidative stress, immune reactions. article discusses activated by followed differential activation across various diseases. This will ultimately guide researchers developing targeted effective interventions diseases associated with activation. Further, we have discussed how PCR, western blotting, microscopic examination molecules can be leveraged monitor, diagnose, explore involving proteins unique post-translational modifications. underscores pressing need advancements molecular approaches disease detection management RAGE.

Language: Английский

Citations

3
Inflammation unleashed: The role of pyroptosis in chronic liver diseases DOI Creative Commons
Lujian Zhu,

Hongjie Tong,

Chao Ren

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 113006 - 113006

Published: Aug. 29, 2024

Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.

Language: Английский

Citations

3
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway DOI

Thuy Le Lam Nguyen,

Dung Van Nguyen,

Yujin Jin

et al.

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(10-11), P. 854 - 869

Published: Oct. 27, 2024

Language: Английский

Citations

1
Potential Effects of a Human Milk Oligosaccharide 6'-Sialyllactose on Angiotensin Ii-Induced Aortic Aneurysm Via P90rsk/Tgf-B/Smad2 Signaling Pathway DOI

Thuy Le Lam Nguyen,

Dung Van Nguyen,

Yujin Jin

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Breast milk oligosaccharides are the most essential ingredient in breast milk, affecting the health of infants: A review DOI Creative Commons
И. Н. Захарова, Yana V. Orobinskaya, Narine G. Sugian

et al.

Pediatrics Consilium Medicum, Journal Year: 2024, Volume and Issue: 3, P. 326 - 333

Published: Oct. 10, 2024

Breastfeeding remains the “gold standard” of nutrition for children in first years life. However, factors such as hypogalactia, maternal stress, health problems and simply an unwillingness to breastfeed deprive baby breast milk (BM) challenge pediatricians choose alternative food baby. The BM composition is complex, dynamic, scientific interest, attention most scientists directed oligosaccharides (BMOs). Many benefits BMOs have been proven relation child's health, including formation intestinal microbiota, maturation immune response, contribution barrier function intestine, protection against pathogens. In absence breastfeeding, modern formulas containing can be used. addition a combination 5 promising effective approach maintaining overall formula-fed infants.

Language: Английский

Citations

0