Therapeutic Effect of Liquiritin Carbomer Gel on Topical Glucocorticoid-Induced Skin Inflammation in Mice DOI Creative Commons
Yun Zhang, Sijia Li, Yanfang Huang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1001 - 1001

Published: July 28, 2024

Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is dangerous condition that develops after glucocorticoid use. The patients become dependent on medication and, even stopped, dermatitis symptoms recur, severely impairing their quality life. Thus, need to aggressively confront critical. Prior research has demonstrated administration licorice’s flavonoid component liquiritin stimulates epidermal proliferation, which turn enhances creation collagen healing wounds. Therefore, purpose this work was determine if use carbomer gel can treat changes mice mechanisms involved. findings that, model inflammation, aided restoration barrier function. These outcomes have been caused by enhanced expression proteins Aquaporin 3, Keratin 10, Claudin-1, as well hyaluronan content. In meantime, dramatically decreased TNF-α, IL-1β, IL-6, IFN-γ, IgE mice, according ELISA tests. Furthermore, treatment boosted superoxide dismutase, catalase, malondialdehyde expression, counteracting detrimental effects glucocorticoids epidermis. summary, these imply damage through various action.

Language: Английский

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis DOI Creative Commons
Jian Mei, Niqin Xiao, Yujiang Xi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 27, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of ECM and cartilage degeneration. Articular maintained chondrocytes, which secrete ECM, making stability these cells crucial for function. Research has shown that in later stages OA, cavities form, indicating decline chondrocyte Chondrocyte death considered central feature Apoptosis, form programmed cell death, plays key role this process. While controlled apoptosis helps remove damaged chondrocytes protects from injury, excessive disrupts balance microenvironment accelerates OA progression. Therefore, regulating may offer novel approach preventing treating This review examines pathways, interaction between regulatory factors apoptosis, analyzes current drug interventions targeting both preclinical clinical studies. It also discusses challenges outlines future research directions to guide upcoming

Language: Английский

Citations

0
Ultrasonic-assisted membrane processes for the systematic purification of glycyrrhiza wastewater DOI Creative Commons
Cunyu Li, Yun Ma,

Shuwan Tang

et al.

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 111, P. 107098 - 107098

Published: Oct. 8, 2024

Language: Английский

Citations

3
Therapeutic Effect of Liquiritin Carbomer Gel on Topical Glucocorticoid-Induced Skin Inflammation in Mice DOI Creative Commons
Yun Zhang, Sijia Li, Yanfang Huang

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1001 - 1001

Published: July 28, 2024

Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is dangerous condition that develops after glucocorticoid use. The patients become dependent on medication and, even stopped, dermatitis symptoms recur, severely impairing their quality life. Thus, need to aggressively confront critical. Prior research has demonstrated administration licorice’s flavonoid component liquiritin stimulates epidermal proliferation, which turn enhances creation collagen healing wounds. Therefore, purpose this work was determine if use carbomer gel can treat changes mice mechanisms involved. findings that, model inflammation, aided restoration barrier function. These outcomes have been caused by enhanced expression proteins Aquaporin 3, Keratin 10, Claudin-1, as well hyaluronan content. In meantime, dramatically decreased TNF-α, IL-1β, IL-6, IFN-γ, IgE mice, according ELISA tests. Furthermore, treatment boosted superoxide dismutase, catalase, malondialdehyde expression, counteracting detrimental effects glucocorticoids epidermis. summary, these imply damage through various action.

Language: Английский

Citations

1