Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson’s disease DOI
Juliana Cordovil Cotrin, Gilson Costa dos Santos,

André Simões Cadaxo

et al.

Brain Research, Journal Year: 2025, Volume and Issue: 1858, P. 149625 - 149625

Published: April 17, 2025

Language: Английский

Emerging Targets in Amyotrophic lateral sclerosis (ALS): The Promise of ATP-Binding Cassette (ABC) transporter Modulation DOI
Maneesh Mohan, Ashi Mannan,

Aayush Nauriyal

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 476, P. 115242 - 115242

Published: Sept. 6, 2024

Language: Английский

Citations

9
Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases DOI Creative Commons
Guoqiang Guan, Yaoxing Chen, Yulan Dong

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 70 - 70

Published: Jan. 9, 2025

Oxidative stress (OS) refers to the production of a substantial amount reactive oxygen species (ROS), leading cellular and organ damage. This imbalance between oxidant antioxidant activity contributes various diseases, including cancer, cardiovascular disease, diabetes, neurodegenerative conditions. The body’s system, mediated by signaling pathways, includes AMPK-SIRT1-FOXO pathway. In oxidative conditions, AMPK, an energy sensor, activates SIRT1, which in turn stimulates FOXO transcription factor. cascade enhances mitochondrial function, reduces damage, mitigates OS-induced injury. review provides comprehensive analysis biological roles, regulatory mechanisms, functions pathway diseases influenced OS, offering new insights methods for understanding OS pathogenesis its therapeutic approaches.

Language: Английский

Citations

1
A new era of cancer immunotherapy: vaccines and miRNAs DOI Creative Commons

Gitika Sareen,

Maneesh Mohan, Ashi Mannan

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(5)

Published: April 1, 2025

Language: Английский

Citations

1
Aquaporin proteins: A promising frontier for therapeutic intervention in cerebral ischemic injury DOI
Ashi Mannan, Maneesh Mohan,

Anshika Gulati

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111452 - 111452

Published: Oct. 5, 2024

Language: Английский

Citations

6
Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances DOI Creative Commons
Qiu Jiang, Jie Liu, Shan Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 10, 2025

Abstract In the context of global ageing, prevalence neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. However, current symptomatic disease-modifying therapies have achieved limited benefits for in clinical settings. Halting progress neurodegeneration cognitive decline or even improving impaired cognition function are clinically meaningful goals treatments diseases. Ageing primary risk factor their associated comorbidities, vascular pathologies, elderly individuals. Thus, we aim to elucidate role ageing from perspective a complex system, which brain core peripheral organs tissues form holistic network support functions. During progressive deterioration structure entire body hampers its active adaptive responses various stimuli, thereby rendering individuals more vulnerable Consequently, propose that prevention treatment should be grounded antiageing rejuvenation means complemented by interventions targeting disease-specific pathogenic events. This integrated approach promising strategy effectively prevent, pause slow down progression

Language: Английский

Citations

0
Unveiling Acid-Sensing Ion Channels (ASICs) in Neurodegeneration: Implications for Disease Pathogenesis and Therapeutic Strategies DOI
Maneesh Mohan, Ashi Mannan, Thakur Gurjeet Singh

et al.

Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 11, 2025

Language: Английский

Citations

0
Revenge Unraveling the Fortress: Exploring Anticancer Drug Resistance Mechanisms in BC for Enhanced Therapeutic Strategies DOI
Ashi Mannan, Maneesh Mohan, Thakur Gurjeet Singh

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104707 - 104707

Published: March 1, 2025

Language: Английский

Citations

0
Unravelling the role of protein kinase R (PKR) in neurodegenerative disease: a review DOI
Maneesh Mohan, Ashi Mannan, Thakur Gurjeet Singh

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 9, 2025

Language: Английский

Citations

0
Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson’s disease DOI
Juliana Cordovil Cotrin, Gilson Costa dos Santos,

André Simões Cadaxo

et al.

Brain Research, Journal Year: 2025, Volume and Issue: 1858, P. 149625 - 149625

Published: April 17, 2025

Language: Английский

Citations

0