Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species DOI
Abhay Prakash Mishra,

Rajesh Kumar,

Seetha Harilal

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 497 - 532

Published: Oct. 31, 2024

Language: Английский

Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation DOI Creative Commons
Nimeet Desai, Vishakha Tambe, Prasad Pofali

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Language: Английский

Citations

12
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies DOI Creative Commons
Dandan Guo, Songhua Cai,

Lvdan Deng

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 23, 2025

Ferroptosis is a distinct form of iron-dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, various signaling pathways, autophagy, have been demonstrated to influence the induction progression ferroptosis. Recent investigations elucidated that ferroptosis plays crucial role in pathogenesis pulmonary disorders, lung injury, chronic obstructive disease, fibrosis, asthma. increasingly recognized as promising novel strategy for cancer treatment. Various immune cells within tumor microenvironment, CD8+ T cells, macrophages, regulatory natural killer dendritic shown induce modulate process through regulation metabolism pathways. Conversely, can reciprocally alter metabolic environment, leading activation or inhibition functions, thereby modulating responses. This paper reviews molecular mechanism describes discusses connection between microenvironment diseases, development prospect their interaction treatment diseases.

Language: Английский

Citations

0
Applications of Molecular Dynamics in Nanomaterial Design and Characterization - A Review DOI Creative Commons
Md Aminul Islam,

Sayma Rahman,

Juhi Jannat Mim

et al.

Chemical Engineering Journal Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100731 - 100731

Published: March 1, 2025

Language: Английский

Citations

0
Magnetic/Organic Core-Shell Nanoconstructs for Cancer Theranostic DOI
Gaurisha Alias Resha Ramnath Naik,

S. P. Rachana,

Amrita Arup Roy

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Polymer/Lipid Core-Shell Nanoconstructs for Cancer Theragnostic DOI

Viola Colaco,

Anoushka Mukharya,

Amrita Arup Roy

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species DOI
Abhay Prakash Mishra,

Rajesh Kumar,

Seetha Harilal

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 497 - 532

Published: Oct. 31, 2024

Language: Английский

Citations

2