Reflectance Confocal Microscopy Can Help Differentiate Adult Xanthogranulomatous Disease from Xanthelasma—A Case Report
Larysa Krajewska-Węglewicz,
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Monika Dźwigała,
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Piotr Sobolewski
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et al.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(4), P. 1359 - 1359
Published: Feb. 18, 2025
Background:
Adult
xanthogranulomatous
disease
(AXD)
is
a
rare
histiocytic
disorder
with
systemic
potential,
while
xanthelasma
palpebrarum
(XP)
common
xanthoma
often
linked
to
lipid
disorders.
Differentiating
these
conditions
challenging
due
overlapping
features.
Reflectance
confocal
microscopy
(RCM),
non-invasive
imaging
tool,
offers
high-resolution
visualization
of
skin
structures
and
may
aid
diagnosis.
Methods:
We
present
71-year-old
woman
periocular
lesions.
RCM
was
used
evaluate
the
lesions,
identifying
cellular
structural
The
findings
were
confirmed
through
histopathology,
followed
by
surgical
excision.
Postoperative
monitoring
utilized
LC-OCT.
Results:
identified
Touton
giant
cells,
foamy
histiocytes,
fibrosis,
helping
distinguish
xanthogranuloma
from
xanthelasma.
Histopathology
diagnosis,
patient
underwent
successful
lesion
excision
without
complications.
Conclusions:
This
case
underscores
RCM's
utility
as
diagnostic
adjunct
for
differentiating
AXD
XP
in
sensitive
regions
like
area.
combined
use
LC-OCT
enhances
recurrence.
While
histopathology
remains
gold
standard,
shows
promise
warranting
further
research
validate
its
role
develop
standardized
clinical
protocols.
Language: Английский
Very low-dose vemurafenib maintenance for cardiac Erdheim Chester disease
Blood Research,
Journal Year:
2025,
Volume and Issue:
60(1)
Published: April 11, 2025
Language: Английский
Clinical Reasoning: A 59-Year-Old Man With Progressive Dysarthria and Gait Instability
Neurology,
Journal Year:
2025,
Volume and Issue:
104(12)
Published: May 22, 2025
We
report
a
59-year-old
man
with
progressively
deteriorating
neurologic
presentation
characterized
by
dysarthria
and
gait
instability.
Neurologic
examination
revealed
pseudobulbar
palsy,
cerebellar
ataxia,
pyramidal
signs.
Neuroimaging
demonstrated
irregular
brainstem
lesions
minimal
mass
effect
partial
enhancement.
Bilateral
heel
swelling,
an
uncommon
clinical
presentation,
prompted
further
diagnostic
evaluation.
This
case
highlights
the
importance
of
systematic
reasoning
approach,
emphasizing
differential
diagnosis,
investigative
modalities,
treatment
options
for
this
rare
condition,
particular
attention
to
potential
multisystem
involvement.
Language: Английский
Erdheim-chester disease with bilateral proptosis, coated aorta and hairy kidney
Journal of Hematology and Transfusion Medicine,
Journal Year:
2024,
Volume and Issue:
34
Published: Aug. 28, 2024
Erdheim-Chester
disease
(ECD)
is
a
rare
histiocytic
disorder
with
spectrum
of
clinical
manifestations,
ranging
from
asymptomatic
single-organ
involvement
to
multisystem
disease.
We
present
classic
case
ECD
detailed
radiographic
and
histopathologic
findings.
A
63-year-old
Thai
female
history
triple
vessel
post-PCI
presented
bilateral
proptosis
blurred
vision
for
one
year.
On
admission,
she
exhibited
marked
epiblepharon,
lagophthalmos,
conjunctival
injection,
chemosis,
limited
extraocular
movement
cranial
nerve
II
palsy.
Imaging
showed
increased
retro-orbital
infiltrative
lesions,
osteosclerotic
changes,
soft
tissue
thickening
along
the
great
vessels
retroperitoneum.
biopsy
foamy
proliferation
Touton
giant
cells.
EDC
was
confirmed
by
next-generation
sequencing
revealing
BRAF
V600E
mutation.
This
patient
received
pegylated
interferon-alpha.
At
1-year
follow-up
visit,
remained
stable.
In
this
report,
we
EDC.
The
rarity
makes
it
challenging
diagnose.
typical
presentation
characteristics
raise
awareness
diagnosis
EDC,
which
based
on
features
such
as
lesions
in
long
bones,
infiltration
medium
large
(coated
aorta)
pelvicalyceal
systems
(hairy
kidney).
These
findings
were
through
pathology
molecular
diagnostics.
Language: Английский