Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review DOI Creative Commons
Fengya Zhu,

Shao Yin,

Yuan Wang

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5941 - 5958

Published: Dec. 1, 2024

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects probiotics on clinical symptoms and systemic inflammation regulation various NDDs, this systematic review conducted detailed search Cochrane Library, Embase, PubMed, Web Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs Alzheimer's Disease (AD), 10 Parkinson's (PD), 2 Multiple Sclerosis (MS), Mild Cognitive Impairment (MCI), intervention durations ranging from to 16 weeks. The comprehensive analysis indicates that help improve related gastrointestinal function, cognitive quality life, mental health. Additionally, generally positive effect reducing enhancing antioxidant capacity patients. conclusion, existing evidence supports promising NDDs. However, further large-scale, high-quality studies are needed explore specific differences efficacy among probiotic strains, dosages, modes administration. Moreover, considering lifestyle dietary habits may modulate these external factors should also be included research considerations gain more understanding mechanisms application strategies NDDs treatment.

Language: Английский

The intricate interplay between dietary habits and cognitive function: insights from the gut-brain axis DOI Creative Commons
Ruyi Zhang, Meiya Zhang, Pengyu Wang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

The intricate relationship between dietary habits and cognitive function is gaining increasing attention, with a focus on the gut-brain axis as modifiable target for intervention. This review synthesizes evidence impact of patterns, particularly Mediterranean diet, plant-based diets, low-carbohydrate health. These rich in antioxidants, anti-inflammatory compounds, neuroprotective nutrients, are suggested to slow decline reduce risk neurodegenerative disorders through mechanisms such reduced inflammation oxidative stress, enhanced neurogenesis. diet has been associated improved performance delay elderly populations. However, challenges intervention implementation, including adherence individual variability, remain. Future research must adopt multidisciplinary approach, incorporating long-term, large-scale, multicenter randomized controlled trials assess enduring impacts various patterns function, considering socioeconomic cultural factors. underscores potential interventions prevent mitigate impairment, ultimately aiming improve quality life.

Language: Английский

Citations

1
Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases DOI Open Access

Pola Głowacka,

Katarzyna Oszajca, Agnieszka Pudlarz

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2244 - 2244

Published: July 12, 2024

Aging is the most prominent risk factor for neurodegeneration occurrence. The common neurodegenerative diseases (NDs), Alzheimer’s (AD) and Parkinson’s (PD) diseases, are characterized by incidence of proteinopathy, abnormal activation glial cells, oxidative stress, neuroinflammation, impaired autophagy cellular senescence excessive patient’s age. Moreover, mitochondrial disfunction, epigenetic alterations neurogenesis inhibition, together with increased blood–brain barrier permeability gut dysbiosis, have been linked to ND pathogenesis. Since NDs still lack curative treatment, recent research has sought therapeutic options in restoring microbiota supplementing probiotic bacteria-derived metabolites beneficial action host—so called postbiotics. current review focuses on literature explaining mechanisms involved pathogenesis addressing impact that postbiotics as a whole mixture particular metabolites, such short-chain fatty acids (SCFAs), lactate, polyamines, polyphenols, tryptophan exopolysaccharides bacterial extracellular vesicles, ageing-associated processes underlying also discusses issue implementing into prophylaxis therapy, depicting them compounds senescence-triggered dysfunctions worth translating from bench pharmaceutical market response “silver consumers” demands.

Language: Английский

Citations

8
Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS DOI Open Access
Corneliu Toader,

Călin Petru Tătaru,

Octavian Munteanu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12613 - 12613

Published: Nov. 24, 2024

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS, and Huntington's, remain formidable challenges in medicine, with their relentless progression limited therapeutic options. These diseases arise from a web of molecular disturbances-misfolded proteins, chronic neuroinflammation, mitochondrial dysfunction, genetic mutations-that slowly dismantle neuronal integrity. Yet, recent scientific breakthroughs are opening new paths to intervene these once-intractable conditions. This review synthesizes the latest insights into underlying dynamics neurodegeneration, revealing how intertwined pathways drive course diseases. With an eye on most promising advances, we explore innovative therapies emerging cutting-edge research: nanotechnology-based drug delivery systems capable navigating blood-brain barrier, gene-editing tools like CRISPR designed correct harmful variants, stem cell strategies that not only replace lost neurons but foster neuroprotective environments. Pharmacogenomics is reshaping treatment personalization, enabling tailored align individual profiles, while diagnostics biomarkers ushering era early, precise disease detection. Furthermore, novel perspectives gut-brain axis sparking interest mounting evidence suggests microbiome modulation may play role reducing neuroinflammatory responses linked neurodegenerative progression. Taken together, advances signal shift toward comprehensive, personalized approach could transform care. By integrating techniques, this offers forward-looking perspective future where treatments aim just manage symptoms fundamentally alter progression, presenting renewed hope for improved patient outcomes.

Language: Английский

Citations

6
Postbiotics as a Therapeutic Tool in Alzheimer's Disease: Insights into Molecular Pathways and Neuroprotective Effects DOI

Garry Hunjan,

Khadga Raj Aran

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102685 - 102685

Published: Feb. 1, 2025

Language: Английский

Citations

0
Alterations in protein quality control resulting in neurodegeneration and disease DOI

Prasann Kumar

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 123 - 175

Published: Jan. 1, 2025

Language: Английский

Citations

0
Editorial: Gut microbiota and gastrointestinal disorders, volume II DOI Creative Commons
Abbas Yadegar, Aryan Salahi‐Niri, Yan‐Dong Wang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 17, 2025

The human gut microbiota, an intricate ecosystem of bacteria, viruses, fungi, and archaea, plays a pivotal role in maintaining gastrointestinal (GI) homeostasis (1). Recent advancements microbiome research have unveiled its profound influence on various GI disorders, including gastric cancer, inflammatory bowel disease (IBD), irritable syndrome (IBS), acute pancreatitis, Clostridioides difficile infection (CDI) (2). Understanding the interplay between microbiota these disorders offers promising avenues for novel therapeutic interventions, next-generation probiotics, fecal transplantation (FMT), targeted microbiome-oriented modulation (3,4).Gastric cancer remains significant global health burden, ranking as fourth leading cause cancer-related mortality. Dysbiosis, characterized by altered microbial diversity composition, is hallmark carcinogenesis (Marashi et al.). Helicobacter pylori wellestablished risk factor, yet eradication alone does not fully restore equilibrium. Studies suggest that certain bacterial species, such Lactobacillus, enhance immunotherapy responses, whereas antibiotic-induced dysbiosis can reduce efficacy chemotherapy al.) (5,6). Probiotic supplementation post-gastrectomy has demonstrated potential mitigating inflammation fostering healthier milieu (7). IBD, encompassing Crohn's ulcerative colitis, immune-mediated disorder driven complex genetic, environmental, factors (Ning (8). Dysbiosis relationship metabolic functions extends beyond tract. Emerging explored bidirectional connection insulin-like growth factor 1 (IGF-1), key regulator growth-related pathways (Zheng been implicated modulating IGF-1 levels, suggesting consequences imbalances. This insight broadens scope microbiome-targeted therapies to include alongside diseases.The expanding knowledge underscores need precision medicine approaches. Personalized profiling could guide tailored optimizing outcomes. Probiotics, prebiotics, synbiotics, nextgeneration microbiome-based therapies, engineered consortia postbiotics, offer exciting prospects. Moreover, metagenomics metabolomics will further elucidate host-microbe interactions, paving way strategies (13).In conclusion, published studies this Research Topic highlight integral determinant disease. From IBS multifaceted (Stange Harnessing interventions holds immense revolutionizing management, shifting from symptomatic treatment root-cause (14). As continues unravel complexities future gastroenterology lies leveraging microscopic powerhouse transformative healthcare solutions.

Language: Английский

Citations

0
Microencapsulation of Lactobacillus plantarum using cellulose-based polymers by spray-drying: A probiotic-delivery system for enhanced acid-resistance and storage stability DOI

Danial Gazalian,

Atousa Aliahmadi, Hasan Rafati

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143634 - 143634

Published: April 1, 2025

Language: Английский

Citations

0
Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review DOI Creative Commons
Fengya Zhu,

Shao Yin,

Yuan Wang

et al.

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 5941 - 5958

Published: Dec. 1, 2024

In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects probiotics on clinical symptoms and systemic inflammation regulation various NDDs, this systematic review conducted detailed search Cochrane Library, Embase, PubMed, Web Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs Alzheimer's Disease (AD), 10 Parkinson's (PD), 2 Multiple Sclerosis (MS), Mild Cognitive Impairment (MCI), intervention durations ranging from to 16 weeks. The comprehensive analysis indicates that help improve related gastrointestinal function, cognitive quality life, mental health. Additionally, generally positive effect reducing enhancing antioxidant capacity patients. conclusion, existing evidence supports promising NDDs. However, further large-scale, high-quality studies are needed explore specific differences efficacy among probiotic strains, dosages, modes administration. Moreover, considering lifestyle dietary habits may modulate these external factors should also be included research considerations gain more understanding mechanisms application strategies NDDs treatment.

Language: Английский

Citations

0