Molecular insights into diabetic wound healing: Focus on Wnt/β-catenin and MAPK/ERK signaling pathways DOI
Shivam Pandey,

Tushar Anshu,

Krushna Ch Maharana

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 191, P. 156957 - 156957

Published: May 13, 2025

Language: Английский

Ficus pumila fruit polysaccharide alleviates OVA-induced allergic asthma mice through the MAPK/NF-κB signaling pathway DOI
Xiaomei Ye,

Shiru Mo,

Chengyuan Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105827 - 105827

Published: Jan. 1, 2025

Language: Английский

Citations

0
Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment DOI Creative Commons
Franziska Peters,

Windie Höfs,

Hunki Lee

et al.

The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(4)

Published: Jan. 29, 2025

Sphingolipids serve as building blocks of membranes to ensure subcellular compartmentalization and facilitate intercellular communication. How cell type–specific lipid compositions are achieved what is their functional significance in tissue morphogenesis maintenance has remained unclear. Here, we identify a stem cell–specific role for ceramide synthase 4 (CerS4) orchestrating fate decisions skin epidermis. Deletion CerS4 prevents the proper development adult hair follicle bulge (HFSC) compartment due altered differentiation trajectories. Mechanistically, HFSC defects arise from an imbalance key ceramides derivate sphingolipids, resulting hyperactivation noncanonical Wnt signaling. This impaired establishment leads disruption architecture barrier function, ultimately triggering T helper 2–dominated immune infiltration resembling human atopic dermatitis. work uncovers fundamental state–specific sphingolipid profile homeostasis maintaining intact barrier.

Language: Английский

Citations

0
Overexpression of Methionine Sulfoxide Reductase A Alleviates Acrylamide-Induced Neurotoxicity by Mitigating Lipid Peroxidation and Mitochondria-Dependent Apoptosis In Vivo and In Vitro DOI
Yuanyuan Li, Tingting Zhang,

Qiaoxing Mou

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115339 - 115339

Published: Feb. 1, 2025

Language: Английский

Citations

0
Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neuropsychiatric disorders DOI Creative Commons
Egon A. Ozer, Abdurrahman Keskin,

Yusuf Huseyin Berrak

et al.

Discover Mental Health, Journal Year: 2025, Volume and Issue: 5(1)

Published: Feb. 22, 2025

Viral infections may disrupt the structural and functional integrity of nervous system, leading to acute conditions such as encephalitis, neuropsychiatric mood disorders, schizophrenia, neurodegenerative diseases. Investigating viral interactions human proteins reveal mechanisms underlying these effects offer insights for therapeutic interventions. This study explores molecular virus that be related disorders. Herpes Simplex Virus-1 (HSV-1), Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), Influenza A (IAV) (H1N1, H5N1), Human Immunodeficiency (HIV1&2) were selected key viruses. Protein structures each accessed from Data Bank analyzed using HMI-Pred web server detect interface mimicry between proteins. The PANTHER classification system was used categorize viral-human protein based on function cellular localization. Energetically favorable identified HSV-1 (467), CMV (514), EBV (495), H1N1 (3331), H5N1 (3533), HIV 1&2 (62425). Besides immune apoptosis-related pathways, including those associated with Parkinson's Huntington's diseases, frequently interacted. total 38 proteins, calmodulin 2, Ras-related botulinum toxin substrate 1 (Rac1), PDGF-β, vimentin, found interact all six indicates a substantial number energetically underscoring complexity breadth strategies hijack host mechanisms. Further in vivo vitro validation is required understand implications interactions.

Language: Английский

Citations

0
The relationship between MAPK signaling pathways and osteogenic differentiation of periodontal ligament stem cells: a literature review DOI Creative Commons

Xuanning Liu,

Wanqing Zhao,

Yanhui Peng

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19193 - e19193

Published: March 31, 2025

Periodontitis is a common oral disease that can lead to gingival inflammation, development of periodontal pockets, resorption the alveolar bone, and loosening eventual loss teeth. The optimal outcome periodontitis treatment maximum regeneration functional reconstruction tissues after control infection elimination inflammation. Since both self-healing ability bone efficacy traditional methods are very limited, stem cell-based tissue engineering has received more attention from scholars. best cells for have been well examined, these called ligament (PDLSCs). MAPK signaling pathways, including ERK1/2, p38 MAPK, JNK, ERK5 complex highly conserved tertiary kinase pathways. These pathways closely related osteogenic differentiation PDLSCs, this paper provides an overview research on PDLSCs.

Language: Английский

Citations

0
CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: a novel mechanism and therapeutic target DOI Creative Commons

Changteng Zhang,

Xiaoyu Zhu, Rui Gao

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2025, Volume and Issue: 36(2), P. 102555 - 102555

Published: May 8, 2025

Language: Английский

Citations

0
Molecular insights into diabetic wound healing: Focus on Wnt/β-catenin and MAPK/ERK signaling pathways DOI
Shivam Pandey,

Tushar Anshu,

Krushna Ch Maharana

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 191, P. 156957 - 156957

Published: May 13, 2025

Language: Английский

Citations

0