From HHV-6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID. DOI
Michaël Maes, Abbas F. Almulla,

Xiaoou Tang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 30, 2024

Abstract Background Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome (CFS) symptoms, labeled “the physio-affective phenome.” Objectives To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 reactivation (HHV-6), directed against oligodendrocyte neuronal including myelin basic protein (MBP). Methods IgA / IgM/IgG Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive (CRP) advanced oxidation products (AOPP), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Results Neural network identified LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC most important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-MPB IgG-MBP. A large part variances both MBP (36.3-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 reactivation, which turn increased IgM-SARS-CoV-2. Conclusions Autoimmunity components junctions bacterial translocation may be involved COVID’s phenome.

Language: Английский

Regulation of the microglial polarization for alleviating neuroinflammation in the pathogenesis and therapeutics of major depressive disorder DOI
Yufei Wang,

Cong-Ya Chen,

Lan Lei

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 362, P. 123373 - 123373

Published: Jan. 4, 2025

Language: Английский

Citations

2
Ginsenoside Rg1: A natural triterpenoid glycoside with promising anti-depressive properties DOI
Yating Wang, Jun-Jie Jiang, Yi Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105940 - 105940

Published: Jan. 1, 2025

Language: Английский

Citations

2
Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis DOI

Wiktor Śliwiński,

Oliwia Gawlik-Kotelnicka

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 472, P. 115145 - 115145

Published: July 9, 2024

Language: Английский

Citations

9
Omega-3 Polyunsaturated Fatty Acids: A Clinical Perspective on Gut Microbiota, Major Depressive Disorder, and Obesity DOI
Jane Pei‐Chen Chang, Suet‐Kei Wu, Lucile Capuron

et al.

Psychiatric Annals, Journal Year: 2025, Volume and Issue: 55(2)

Published: Feb. 1, 2025

Major depressive disorder (MDD) and obesity are significant global health concerns with a strong bidirectional relationship. Gut microbiota dysbiosis has been implicated in both MDD obesity, characterized by alterations microbial diversity its metabolites. Omega-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA), docosahexaenoic (DHA) have shown promise alleviating symptoms improving metabolic health. Diet plays crucial role shaping gut microbiota, omega-3 PUFAs emerging as potential therapeutic target. By modulating reducing inflammation, influencing neurotransmitter systems, may offer novel approach to treating obesity. This article will investigate the of relationship between depression via microbiome inflammation. Further investigation is needed establish optimal dosage supplementation for individuals comorbid [ Psychiatr Ann . 2025;55(2):e34–e39.]

Language: Английский

Citations

1
Parkin, a Parkinson's disease-associated protein, mediates the mitophagy that plays a vital role in the pathophysiology of major depressive disorder DOI
Yi Zhang

Neurochemistry International, Journal Year: 2024, Volume and Issue: 179, P. 105808 - 105808

Published: July 22, 2024

Language: Английский

Citations

7
The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects DOI Open Access
Luana de Fátima Alves, J. Bernadette Moore, Douglas B. Kell

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9082 - 9082

Published: Aug. 21, 2024

Kynurenic acid (KYNA) is an antioxidant degradation product of tryptophan that has been shown to have a variety cytoprotective, neuroprotective and neuronal signalling properties. However, mammalian transporters receptors display micromolar binding constants; these are consistent with its typically tissue concentrations but far above serum/plasma concentration (normally tens nanomolar), suggesting large gaps in our knowledge transport mechanisms action, the main influx characterized date equilibrative, not concentrative. In addition, it substrate known anion efflux pump (ABCC4), whose vivo activity largely unknown. Exogeneous addition L-tryptophan or L-kynurenine leads production KYNA also many other co-metabolites (including some such as 3-hydroxy-L-kynurenine quinolinic may be toxic). With exception chestnut honey, exists at relatively low levels natural foodstuffs. bioavailability reasonable, terminal element irreversible reaction most pathways, might added exogenously without disturbing upstream metabolism significantly. Many examples, which we review, show valuable bioactivity. Given above, review potential utility nutraceutical, finding significantly worthy further study development.

Language: Английский

Citations

6
Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models DOI Creative Commons

Hu Yue,

Yaoxue Gan,

Lei Jia

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238

Published: Feb. 24, 2025

Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.

Language: Английский

Citations

0
Berberine: an isoquinoline alkaloid targeting the oxidative stress and gut-brain axis in the models of depression DOI

Cong-Ya Chen,

Yi Zhang

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117475 - 117475

Published: March 1, 2025

Language: Английский

Citations

0
The regulatory mechanism of intermittent fasting and probiotics on cognitive function by the microbiota‐gut‐brain axis DOI
Yili Chen, Chi‐Tang Ho, Xin Zhang

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(3)

Published: March 1, 2025

Abstract Intermittent fasting (IF) is an eating pattern that promotes health and cognitive improvement through periodic eating. It has been shown to enhance neuroplasticity reduce oxidative stress inflammation. Recent studies have demonstrated probiotic supplementation enhances performance by modulating gut microbiota composition increasing short‐chain fatty acid production, which in turn neurogenesis synaptic plasticity. The microbiota‐gut‐brain axis (MGBA) the communication bridge between brain, influencing function immune, endocrine, nervous systems. combination of probiotics IF may exert complementary effects on function, with enhancing microbial diversity metabolic efficiency, while further modulate barrier integrity neurotransmitter synthesis. This review critically examines interplay via MGBA, identifying key mechanisms potential therapeutic strategies remain underexplored current research.

Language: Английский

Citations

0
Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment DOI Open Access
Anna Giulia Bottaccioli, Mauro Bologna, Francesco Bottaccioli

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2759 - 2759

Published: March 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Language: Английский

Citations

0