The association of chronic pain, painkiller use, and potential mediators with liver fat content

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 25, 2025

Excessive accumulation of liver fat content (LFC) is a pathological manifestation steatotic diseases. This study aims to investigate the relationship between chronic pain and LFC development. In UK Biobank, sites were collected via questionnaire, while was measured by magnetic resonance imaging quantified Proton Density Fat Fraction (PDFF). During median follow-up 10.5 (4.0-17.8) years, in 39,437 individuals, neck/shoulder, back, stomach/abdominal, knee, general achieved significant arithmetic means difference 0.02, 0.04, 0.15 PDFF (P < 0.05) using multivariable linear regression models. There dose-effect for number 0.001). Additionally, link much stronger aspirin users than non-users, steroids had reverse effect interaction 0.05). C-reactive protein, sleep, diet, depression proved mediated 8.41%, 13.3%, 6.6%, 23.0% relationship, respectively. conclusion, there differences LFC. For patients with potential health issues, may be prioritized as an analgesic option due its protective benefits, whereas steroid medications should avoided.

Language: Английский

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Mitigation of benzo(a)pyrene-induced hepatotoxicity and oxidative damage in Nile tilapia (Oreochromis niloticus) using N-acetylcysteine-loaded starch nanoparticles in porous alginate beads through the CYP1A/Nrf2/HO-1 pathway

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(3)

Published: March 4, 2025

Language: Английский

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The Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2882 - 2882

Published: March 22, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition wherein excessive fat accumulates in the liver, leading to inflammation and potential damage. In this narrative review, we evaluate tissue microbiota, how they arise their constituent microbes, role of intestinal hepatic microbiota MASLD. The history bacteriophages (phages) occurrence part causation MASLD, conversely, "phage therapy" for antibiotic resistance, obesity, are all described. metabolism bile acids dietary tryptophan histidine defined, together with impacts individual metabolites on MASLD pathogenesis. Both periodontitis dysbiosis may cause microorganisms involved these processes discussed. Novel treatment opportunities involving exist include fecal transplantation, probiotics, prebiotics, synbiotics, supplements, intermittent fasting, phages or holins endolysins. Although FDA yet approve phage therapy clinical use, there multiple FDA-approved trials, represent new horizon future

Language: Английский

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Mast Cells and Microbiome in Health and Disease

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)

Published: March 20, 2025

Inter-kingdom communication between human microbiota and mast cells (MCs), as sentinels of innate immunity, is crucial in determining health disease. This complex signaling hub involves micro-organisms and, more importantly, their metabolic products. Gut the host’s largest symbiotic ecosystem under physiological conditions, it plays a vital role mediating MCs tolerogenic priming, thus ensuring immune homeostasis across organs. Conversely, intestinal dysbiosis various etiologies promotes MC-oriented inflammation along major body axes, including gut-skin, gut-lung, gut-liver, gut-brain. review international scientific literature provides comprehensive overview cross-talk investigation. process key biological event involved disease development clinical fields, with significant prognostic therapeutic implications for future research.

Language: Английский

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Impact of gut microbiota on metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma: pathways, diagnostic opportunities and therapeutic advances

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Oct. 5, 2024

Language: Английский

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Addressing the alarming link between nonalcoholic fatty liver disease and cardiovascular mortality in men

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(9), P. 502 - 507

Published: Sept. 19, 2024

This editorial discusses the key findings presented in Batta and Hatwal’s recent paper titled “Excess cardiovascular mortality men with non-alcoholic fatty liver disease: A cause for concern!”, which was published World Journal of Cardiology . Their original article highlights a notable correlation between nonalcoholic disease (NAFLD) increased risk men. The present commentary explores implications their findings, discussing potential mechanisms, factors, urgent need integrated clinical approaches to mitigate dual burden these diseases. Emphasis should be placed on importance early detection, lifestyle modifications, interdisciplinary collaboration improving patient outcomes. aims highlight broad NAFLD health advocate awareness proactive management strategies within medical community.

Language: Английский

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