Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use DOI Creative Commons
Pichet Ruenchit

Current Research in Parasitology and Vector-Borne Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 100256 - 100256

Published: March 1, 2025

Many antiparasitic drugs have become obsolete and ineffective in treating parasitic diseases. This ineffectiveness arises from parasite drug resistance, high toxicity, low efficacy. Thus, the discovery of novel agents is urgently needed to control Various strategies are employed discovery, design, development. review highlights paradigm searching for bioactive molecules produced during inter- intraspecific competition among organisms, particularly between microbes parasites, as a strategy de novo discovery. Competitive interactions occur when individuals same or different species coexist overlapping niches compete space resources. These well recognized. Therefore, released these promising targets Compelling data indicate that remain potential source because their diversity. antimicrobial producers nature yet be isolated investigated. body evidence underscores success numerous therapeutic drugs, including penicillin, β-lactams, tetracyclines, which been successfully discovered developed infectious comprehensively covers concepts, with particular focus on agents. approach will pave way identifying alternative eradicate diseases continue threaten human health. Additionally, this discusses current mechanisms action, limitations, existing gaps. discussion emphasizes ongoing need explore drugs.

Language: Английский

Metal Oxide–Enhanced Para-Coumaric Acid Nanoparticles for Precision Targeting of Leishmania donovani DOI
Kartikesh Sahu,

Raj Amrit Singh Samant,

Tiasha Routh

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors DOI Creative Commons

David J. Shirley,

Meganathan Nandakumar,

Aurora Cabrera

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Candida albicans is a major cause of systemic candidiasis, severe fungal infection with ∼40% mortality rate. Yck2, casein kinase 1 (CK1) in C. albicans, targeted by antifungal inhibitors YK-I-02 (YK) and MN-I-157 (MN). Using multiplexed inhibitor beads mass spectrometry (MIB/MS), the selectivity these was determined across kinome. The MIB matrix captured 89% protein kinases, revealing that YK MN selectively engage three CK1 homologues (Yck2, Yck22, Hrr25) human p38α homologue (Hog1). Chemoproteomics using custom MN-kinobead confirmed remarkable kinome selectivity. To identify new Yck2 over Hog1, 13 were screened, leading to discovery chemotype activity. These findings highlight utility MIB/MS profiling nonhuman kinomes developing selective as antimicrobial agents.

Language: Английский

Citations

0
Exploring bioactive molecules released during inter- and intraspecific competition: A paradigm for novel antiparasitic drug discovery and design for human use DOI Creative Commons
Pichet Ruenchit

Current Research in Parasitology and Vector-Borne Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 100256 - 100256

Published: March 1, 2025

Many antiparasitic drugs have become obsolete and ineffective in treating parasitic diseases. This ineffectiveness arises from parasite drug resistance, high toxicity, low efficacy. Thus, the discovery of novel agents is urgently needed to control Various strategies are employed discovery, design, development. review highlights paradigm searching for bioactive molecules produced during inter- intraspecific competition among organisms, particularly between microbes parasites, as a strategy de novo discovery. Competitive interactions occur when individuals same or different species coexist overlapping niches compete space resources. These well recognized. Therefore, released these promising targets Compelling data indicate that remain potential source because their diversity. antimicrobial producers nature yet be isolated investigated. body evidence underscores success numerous therapeutic drugs, including penicillin, β-lactams, tetracyclines, which been successfully discovered developed infectious comprehensively covers concepts, with particular focus on agents. approach will pave way identifying alternative eradicate diseases continue threaten human health. Additionally, this discusses current mechanisms action, limitations, existing gaps. discussion emphasizes ongoing need explore drugs.

Language: Английский

Citations

0