Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions DOI Creative Commons
Hye Jin Hwang,

Youngsang Nam,

Chanhee Jang

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 6 - 6

Published: Dec. 26, 2024

Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as promising source anticancer compounds, offering unique structural diversity potent biological activity. This review identifies discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures reported activities against cancer cell lines. Notably, plant-derived such rubipodanin A mallotumides A-C demonstrated low nanomolar IC50 values multiple types, highlighting potential. By integrating traditional ethnobotanical knowledge with modern genomic bioinformatic approaches, this study underscores importance resource for developing innovative treatments. These findings pave way further exploration RiPPs, emphasizing role in addressing ongoing challenges oncology enhancing repertoire effective therapies.

Language: Английский

Role of the sulfur-containing amino acid-ROS axis in cancer chemotherapeutic drug resistance DOI
Bingli Wu, Yinwei Cheng, Liyan Li

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: unknown, P. 101238 - 101238

Published: March 1, 2025

Language: Английский

Citations

0
TPD52 (isoform 3) promotes resistance to mTOR-targeted inhibitors by regulating c-Myc, PTEN, and direct activation of 4E-BP1 in LNCaP androgen-dependent cells DOI

Priyanka Khilar,

Ramesh Ummanni

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151495 - 151495

Published: Feb. 1, 2025

Language: Английский

Citations

0
3D tumor cultures for drug resistance and screening development in clinical applications DOI Creative Commons
Zheng Peng,

Xiaolan Lv,

Hao Sun

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 21, 2025

Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more effectively simulates vivo physiological environment, has gained increasing attention research and applications. By mimicking cellular microenvironment, 3D technology not only recapitulates cell-cell interactions but also faithfully reproduces biological effects therapeutic agents. Consequently, is emerging as crucial tool biomedical research. We summarize benefits models organoid explore their application realm resistance, screening, personalized therapy, discuss potential prospects challenges transformation, with aim providing insights for optimizing treatment strategies advancing precision therapy.

Language: Английский

Citations

0
Polymer-Based Antimicrobial Peptide Mimetics for Treating Multi-drug Resistant Infections: Therapy and Toxicity Evaluation DOI
Karthick Harini, Koyeli Girigoswami, Anbazhagan Thirumalai

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2024, Volume and Issue: 30(6)

Published: Sept. 30, 2024

Language: Английский

Citations

3
Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions DOI Creative Commons
Hye Jin Hwang,

Youngsang Nam,

Chanhee Jang

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 6 - 6

Published: Dec. 26, 2024

Cancer remains a significant medical challenge, necessitating the discovery of novel therapeutic agents. Ribosomally synthesized and post-translationally modified peptides (RiPPs) from plants have emerged as promising source anticancer compounds, offering unique structural diversity potent biological activity. This review identifies discusses cytotoxic RiPPs across various plant families, focusing on their absolute chemical structures reported activities against cancer cell lines. Notably, plant-derived such rubipodanin A mallotumides A-C demonstrated low nanomolar IC50 values multiple types, highlighting potential. By integrating traditional ethnobotanical knowledge with modern genomic bioinformatic approaches, this study underscores importance resource for developing innovative treatments. These findings pave way further exploration RiPPs, emphasizing role in addressing ongoing challenges oncology enhancing repertoire effective therapies.

Language: Английский

Citations

0