Repeated intermittent administration of 3,4-methylenedioxymethamphetamine mitigates demyelination in the brain from cuprizone-treated mice
Mingming Zhao,
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Akifumi Eguchi,
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Rumi Murayama
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et al.
European Journal of Pharmacology,
Journal Year:
2025,
Volume and Issue:
991, P. 177345 - 177345
Published: Feb. 2, 2025
3,4-Methylenedioxymethamphetamine
(MDMA),
commonly
known
as
a
recreational
drug,
may
also
offer
therapeutic
benefits
for
mental
health.
Population-based
studies
suggest
that
MDMA
users
have
lower
risk
of
demyelinating
diseases,
such
depression.
Given
the
role
gut
microbiota
in
mediating
MDMA's
effects,
we
hypothesized
might
confer
health
via
gut-brain
axis.
Cuprizone
(CPZ)
induces
demyelination
by
chelating
copper,
which
leads
to
oligodendrocyte
death
and
subsequent
myelin
loss.
This
study
investigated
impact
on
brain
CPZ-treated
mice,
focusing
Repeated
intermittent
administration
(10
mg/kg,
three
times
weekly
6
weeks)
significantly
reduced
corpus
callosum
(CC)
mice.
Gut
non-targeted
metabolomics
analyses
revealed
notable
differences
specific
bacteria
plasma
(β-D-allose
L-sorbose)
or
fecal
metabolite
(carnitine)
levels
between
MDMA-treated
vehicle-treated
CPZ-exposed
Negative
correlations
were
found
metabolites
(β-D-allose,
L-sorbose,
carnitine)
relative
abundance
Romboutsia
timonensis.
These
findings
alleviate
CC
mice
Further
research
is
needed
elucidate
roles
effects
investigate
other
models.
Language: Английский
Gut microbiota regulates optic nerve fiber myelination
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 20, 2025
Recent
evidence
supports
the
hypothesis
of
an
association
between
gut
microbiota
and
pathogenesis
retinal
eye
diseases,
suggesting
existence
a
gut-eye
axis.
However,
no
data
are
available
on
possible
effect
optic
nerve
fiber
maturation
myelin
development.
We
investigated
impact
nerves
collected
from
neonatal
young
adult
germ-free
(GF),
gnotobiotic
(stably
colonized
with
12
bacteria
strains,
OMM12)
control
(colonized
complex
microbiota,
CGM)
mice,
by
performing
stereological
morphoquantitative
analyses
transmission
electron
microscopy
gene
expression
analysis
quantitative
real-time
PCR.
Young
GF
OMM12
axons
smaller
hypermyelinated
compared
to
CGM
ones,
while
such
differences
were
detected
in
nerves.
The
transcription
factors
Olig1,
Olig2,
Sox10
(oligodendrocyte
myelination
positive
regulators)
downregulated
mice
respective
neonates.
Such
developmental
downregulation
was
not
observed
nerves,
that
absence
prolongs
stimulation
myelination,
possibly
through
mechanisms
yet
be
identified.
Altogether,
these
underscore
pivotal
role
driving
contributing
our
knowledge
about
both
axis
gut-brain
axis,
opening
new
horizons
for
further
investigations
will
explore
also
pathologies,
injuries
regeneration
associated
nerve.
Language: Английский
Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD)
International review of neurobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Gut microbiome-gut brain axis-depression: interconnection
The World Journal of Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 36
Published: Dec. 23, 2024
The
relationship
between
the
gut
microbiome
and
mental
health,
particularly
depression,
has
gained
significant
attention.
This
review
explores
connection
microbial
metabolites,
dysbiosis,
depression.
microbiome,
comprising
diverse
microorganisms,
maintains
physiological
balance
influences
health
through
gut-brain
axis,
a
communication
pathway
central
nervous
system.
Language: Английский