miR-574-5p in epigenetic regulation and Toll-like receptor signaling DOI Creative Commons

James Y. Yang

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 26, 2024

miR-574-5p is an unusual microRNA (miRNA) that often upregulated or downregulated following exposure to irradiation toxic chemicals; bacterial, parasitic viral infection; and a variety of other disease conditions. Canonically, epigenetically regulates the expression many messenger RNAs (mRNAs) through miRNA-mediated posttranscriptional regulation, thereby affecting cellular physiology pathophysiology contributing pathogenesis progression diseases. However, recent studies have established in addition serving as fine-tuning repressor gene expression, also stimulates endogenous ligand for Toll-like receptor-8/7 (TLR8/7). Indeed, binding TLR8/7 triggers TLR signaling pathway, leading induction interferons, inflammatory cytokines autoimmune signaling. These findings suggest not only important epigenetic regulator but immune responses. Abnormal miR-574-5p-TLR8/7 has been shown be tightly associated with inflammation-related cancers number disorders. can serve potential biomarker Most importantly, promising therapeutic target treatment prevention human disorders, especially infectious diseases,

Language: Английский

Resveratrol-Enhanced Human Neural Stem Cell-Derived Exosomes Mitigate MPP+-Induced Neurotoxicity Through Activation of AMPK and Nrf2 Pathways and Inhibition of the NLRP3 Inflammasome in SH-SY5Y Cells DOI Creative Commons
Tony F. Chan, Yuping Yang, Christopher J.B. Nicol

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 294 - 294

Published: Feb. 13, 2025

Parkinson's disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in substantia nigra. Mitochondrial dysfunction, oxidative stress, and neuroinflammation are recognized as critical pathological mechanisms driving neurodegeneration PD. Exosome (Exo)-based therapies, particularly those derived from human neural stem cells (hNSCs), offer promising neuroprotective effects due to their ability transfer bioactive molecules that modulate cellular processes. Resveratrol (RES), polyphenolic compound with potent antioxidant anti-inflammatory properties, has been shown enhance therapeutic potential cell (SC)-derived Exos. This study investigated RES-treated hNSCs-derived Exos (RES-hNSCs-Exos) on SH-SY5Y exposed 1-methyl-4-phenylpyridinium (MPP+), neurotoxin commonly used model Parkinsonian neurotoxicity. Treating MPP+ led significant reductions viability, mitochondrial increased activation inflammatory pathways. Treatment RES-hNSCs-Exos rescued MPP+-induced toxicity improving enhancing ATP production, increasing biogenesis, reducing reactive oxygen species (ROS) generation. The findings also demonstrated expression essential genes involved such PGC1α, NRF1, Tfam, indicating improved function presence RES-hNSCs-Exos. Further analysis revealed these protective were mediated activating AMP-activated protein kinase (AMPK) Nrf2 signaling pathways, which promoted health reduced stress. Moreover, treatment suppressed downregulating NLRP3 inflammasome secretion pro-inflammatory cytokines IL-1β IL-18. In conclusion, results suggest exhibit against neurotoxicity function, inhibiting neuroinflammation. These highlight hNSCs-Exos novel strategy for diseases like PD, RES valuable enhancer efficacy.

Language: Английский

Citations

1
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications DOI Open Access
Corneliu Toader, Adrian Dumitru,

Lucian Eva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13302 - 13302

Published: Dec. 11, 2024

This review aims to address the significant challenges of treating central nervous system (CNS) disorders such as neurodegenerative diseases, strokes, spinal cord injuries, and brain tumors. These are difficult manage due complexity disease mechanisms protective blood–brain barrier (BBB), which restricts drug delivery. Recent advancements in nanoparticle (NP) technologies offer promising solutions, with potential applications delivery, neuroprotection, neuroregeneration. By examining current research, we explore how NPs can cross BBB, deliver medications directly targeted CNS regions, enhance both diagnostics treatment. Key NP strategies, passive targeting, receptor-mediated transport, stimuli-responsive systems, demonstrate encouraging results. Studies show that may improve minimize side effects, increase therapeutic effectiveness models Alzheimer’s, Parkinson’s, stroke, glioblastoma. thus represent a approach for disorder management, combining delivery diagnostic capabilities enable more precise effective treatments could significantly benefit patient outcomes.

Language: Английский

Citations

4
Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway DOI

Peng-Fei Yan,

Junchao Wang,

Xiyu Zhao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041

Published: Feb. 1, 2025

Language: Английский

Citations

0
The effect of electric field microenvironment on the exosome secretion of PC12 cells by chitosan carbon dots DOI

Z.Y. Li,

Huajun Wang, Lin Zhou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142747 - 142747

Published: April 1, 2025

Language: Английский

Citations

0
miR-574-5p in epigenetic regulation and Toll-like receptor signaling DOI Creative Commons

James Y. Yang

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 26, 2024

miR-574-5p is an unusual microRNA (miRNA) that often upregulated or downregulated following exposure to irradiation toxic chemicals; bacterial, parasitic viral infection; and a variety of other disease conditions. Canonically, epigenetically regulates the expression many messenger RNAs (mRNAs) through miRNA-mediated posttranscriptional regulation, thereby affecting cellular physiology pathophysiology contributing pathogenesis progression diseases. However, recent studies have established in addition serving as fine-tuning repressor gene expression, also stimulates endogenous ligand for Toll-like receptor-8/7 (TLR8/7). Indeed, binding TLR8/7 triggers TLR signaling pathway, leading induction interferons, inflammatory cytokines autoimmune signaling. These findings suggest not only important epigenetic regulator but immune responses. Abnormal miR-574-5p-TLR8/7 has been shown be tightly associated with inflammation-related cancers number disorders. can serve potential biomarker Most importantly, promising therapeutic target treatment prevention human disorders, especially infectious diseases,

Language: Английский

Citations

0