An FGF2-Derived Short Peptide Attenuates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting Collagen Deposition and Epithelial–Mesenchymal Transition via the FGFR/MAPK Signaling Pathway

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 517 - 517

Published: Jan. 9, 2025

Following the COVID-19 pandemic, prevalence of pulmonary fibrosis has increased significantly, placing patients at higher risk and presenting new therapeutic challenges. Current anti-fibrotic drugs, such as Nintedanib, can slow decline in lung function, but their severe side effects highlight urgent need for safer more targeted alternatives. This study explores potential underlying mechanisms an endogenous peptide (P5) derived from fibroblast growth factor 2 (FGF2), developed by our research team. Using a bleomycin-induced mouse model, we observed that P5 alleviated inhibiting collagen deposition, confirmed CT scans histological staining. In TGF-β-induced cell models, effectively suppressed deposition epithelial–mesenchymal transition (EMT). Transcriptome analysis highlighted pathways related to receptor binding, extracellular matrix organization, adhesion, with KEGG confirming FGFR/MAPK signaling inhibition primary mechanism its effects. summary, demonstrates significantly attenuates through EMT, signaling, providing promising approach fibrosis.

Language: Английский

A novel role for the regulatory NRP1 in immune and inflammatory reactions during radiation-induced lung injury

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142307 - 142307

Published: March 1, 2025

Language: Английский