LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson’s Disease DOI Open Access
Cristina Ciampelli, Grazia Galleri,

Manuela Galioto

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2093 - 2093

Published: Feb. 27, 2025

Parkinson's disease (PD) is a fatal neurodegenerative for which there are no still effective treatments able to stop or slow down neurodegeneration. To date, pathological mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as major genetic cause of PD, although molecular mechanism responsible loss dopaminergic neurons cryptic. In this review, we explore contribution Drosophila models elucidation LRRK2 function different cellular pathways either glial cells. Importantly, recent studies shown that highly expressed immunocompetent cells, including astrocytes and microglia brain, compared neuronal expression. also strongly associated with development inflammatory diseases production molecules. Using models, paper shows reduction response protects flies from neurodegeneration induced by mutant

Language: Английский

LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson’s Disease DOI Open Access
Cristina Ciampelli, Grazia Galleri,

Manuela Galioto

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2093 - 2093

Published: Feb. 27, 2025

Parkinson's disease (PD) is a fatal neurodegenerative for which there are no still effective treatments able to stop or slow down neurodegeneration. To date, pathological mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as major genetic cause of PD, although molecular mechanism responsible loss dopaminergic neurons cryptic. In this review, we explore contribution Drosophila models elucidation LRRK2 function different cellular pathways either glial cells. Importantly, recent studies shown that highly expressed immunocompetent cells, including astrocytes and microglia brain, compared neuronal expression. also strongly associated with development inflammatory diseases production molecules. Using models, paper shows reduction response protects flies from neurodegeneration induced by mutant

Language: Английский

Citations

0