Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis DOI Creative Commons
Yulong Fu,

Canran Gao,

Hailing Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Injectable hydrogel implants represent a promising therapeutic approach for ischemic heart failure; but their efficacy is often limited by low bioactivity, poor durability, and inadequate injection techniques. Herein, unique incorporating extracellular matrix from fish swim bladder (FSB‐ECM), which has distinct advantages over mammalian derived ECM, such as antigenicity, source safety, developed. It consists of collagen, glycoproteins, proteoglycans, including 13 proteins common in the myocardial three specific proteins: HSPG, Col12a1, vWF. This enhances cardiac cell adhesion stretching while promoting angiogenesis M2 macrophage polarization. In addition, its storage modulus ( G ′) increases time, reaching about 1000 Pa after 5 min, facilitates transcatheter delivery situ gelling. Furthermore, this provides sustained support contractions, exhibiting superior longevity. rat model failure, ejection fraction significantly improves with FSB‐ECM treatment, accompanied increased angiogenesis, reduced inflammation, decreased infarct size. Finally, RNA sequencing combined vitro assays identifies ANGPTL4 key protein involved mediating effects treatment. Overall, new injectable based on suitable possesses remarkable reparative capabilities treating failure.

Language: Английский

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis DOI Creative Commons
Yulong Fu,

Canran Gao,

Hailing Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Injectable hydrogel implants represent a promising therapeutic approach for ischemic heart failure; but their efficacy is often limited by low bioactivity, poor durability, and inadequate injection techniques. Herein, unique incorporating extracellular matrix from fish swim bladder (FSB‐ECM), which has distinct advantages over mammalian derived ECM, such as antigenicity, source safety, developed. It consists of collagen, glycoproteins, proteoglycans, including 13 proteins common in the myocardial three specific proteins: HSPG, Col12a1, vWF. This enhances cardiac cell adhesion stretching while promoting angiogenesis M2 macrophage polarization. In addition, its storage modulus ( G ′) increases time, reaching about 1000 Pa after 5 min, facilitates transcatheter delivery situ gelling. Furthermore, this provides sustained support contractions, exhibiting superior longevity. rat model failure, ejection fraction significantly improves with FSB‐ECM treatment, accompanied increased angiogenesis, reduced inflammation, decreased infarct size. Finally, RNA sequencing combined vitro assays identifies ANGPTL4 key protein involved mediating effects treatment. Overall, new injectable based on suitable possesses remarkable reparative capabilities treating failure.

Language: Английский

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