The emerging role of exercise preconditioning in preventing skeletal muscle atrophy DOI Creative Commons
Xu Zhou, Shiming Li, Lu Wang

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Skeletal muscle atrophy, characterized by the loss of mass and function, can result from disuse, aging, disease, drug. Exercise preconditioning—a form exercise training performed before these harmful threats—induces notable remodeling extensive biochemical adaptations in skeletal muscle, creating a protective phenotype fibers, thus serving as an effective intervention for preventing atrophy. Here, we review current understanding relating to how preconditioning protects damage caused inactivity, sarcopenia, or pharmacological intervention, with emphasis on cellular mechanisms involved. Key highlighted making significant contribution effects fibers include mitochondria; expression cytoprotective proteins such HSP72, SOD2, SESN2, PGC-1α AMPK; regulation oxidative stress. These findings underscore potential non-pharmacological preserving well muscular ultimately improving quality life at-risk populations.

Language: Английский

The emerging role of exercise preconditioning in preventing skeletal muscle atrophy DOI Creative Commons
Xu Zhou, Shiming Li, Lu Wang

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Skeletal muscle atrophy, characterized by the loss of mass and function, can result from disuse, aging, disease, drug. Exercise preconditioning—a form exercise training performed before these harmful threats—induces notable remodeling extensive biochemical adaptations in skeletal muscle, creating a protective phenotype fibers, thus serving as an effective intervention for preventing atrophy. Here, we review current understanding relating to how preconditioning protects damage caused inactivity, sarcopenia, or pharmacological intervention, with emphasis on cellular mechanisms involved. Key highlighted making significant contribution effects fibers include mitochondria; expression cytoprotective proteins such HSP72, SOD2, SESN2, PGC-1α AMPK; regulation oxidative stress. These findings underscore potential non-pharmacological preserving well muscular ultimately improving quality life at-risk populations.

Language: Английский

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