Biomarkers for Health Functional Foods in Metabolic Dysfunction-Associated Steatotic Liver Disorder (MASLD) Prevention: An Integrative Analysis of Network Pharmacology, Gut Microbiota, and Multi-Omics

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3061 - 3061

Published: Sept. 11, 2024

Metabolic dysfunction-associated steatotic liver disorder (MASLD) is increasingly prevalent globally, highlighting the need for preventive strategies and early interventions. This comprehensive review explores potential of health functional foods (HFFs) to maintain healthy function prevent MASLD through an integrative analysis network pharmacology, gut microbiota, multi-omics approaches. We first examined biomarkers associated with MASLD, emphasizing complex interplay genetic, environmental, lifestyle factors. then applied pharmacology identify food components beneficial effects on metabolic function, elucidating their action mechanisms. identifies evaluates halting or reversing development disease in stages, as well that can evaluate success failure such strategies. The crucial role microbiota its metabolites prevention homeostasis discussed. also cover state-of-the-art omics approaches, including transcriptomics, metabolomics, integrated analyses, research preventing MASLD. These advanced technologies provide deeper insights into physiological mechanisms HFF development. concludes by proposing approach developing HFFs targeting prevention, considering Korean regulatory framework. outline future directions bridge gap between basic science practical applications narrative provides a foundation researchers industry professionals interested support health. Emphasis placed maintaining balance focusing early-stage intervention

Language: Английский

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Probiotic Bifidobacterium reduces serum TMAO in unstable angina patients via the gut to liver to heart axis

Liver Research, Journal Year: 2025, Volume and Issue: 9(1), P. 57 - 65

Published: Feb. 19, 2025

Language: Английский

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Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 25, 2025

In the current era, metabolic dysfunction-associated steatotic liver disease (MASLD) has gradually developed into a major type of chronic that is widespread globally. Numerous studies have shown gut microbiota plays crucial and indispensable role in progression MASLD. Currently, become one important entry points for research this disease. Therefore, aim review to elaborate on further associations between MASLD, including changes differences healthy diseased liver. Meanwhile, considering fatty steatohepatitis are abnormal pathological states development exhibits different degrees fibrosis (such as mild severe fibrosis) during progression, we also conduct comparison these use them markers progression. It reveals production action mechanisms short-chain acids bile brought about by microbiota, impact lipopolysaccharide from Gram-negative bacteria addition, regulation inhibition related factors probiotics (including new-generation probiotics) will be explored, which help monitor patients with compositions future carry out personalized targeted therapies microbiota. This achieve progress preventing combating

Language: Английский

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Bellidifolin, a constituent from edible Mongolic Liver Tea (Swertia diluta), promotes lipid metabolism by regulating intestinal microbiota and bile acid metabolism in mice during high fat diet-induced obesity

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106562 - 106562

Published: April 1, 2025

Language: Английский

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The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Bile acids, derived from cholesterol in the liver, consist a steroidal core. Primary bile acids and secondary metabolized by gut microbiota make up acid pool, which modulate nuclear hormone receptors to regulate immunity. Disruptions crosstalk between flora are intimately associated with development course of gastrointestinal inflammation. This review provides an extensive summary production, transport metabolism. It also delves into impact metabolism on body explores involvement acid-microbiota interactions various disease states. Furthermore, potential targeting signaling as means prevent treat inflammatory bowel is proposed. In this review, we primarily address functions diseases. Firstly, summarize signalling factors influencing metabolism, highlighting immune function microbially conjugated unique roles different receptors. Subsequently, emphasize vital role maintaining healthy regulating intestinal barrier function, energy Finally explore differences states, offering new perspectives restoring host's health ecosystem microbiota-bile acid-bile receptor axis.

Language: Английский

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Bile acids enhance fat metabolism and skeletal muscle development in zhijiang duck by modulating gut microbiota

Poultry Science, Journal Year: 2025, Volume and Issue: 104(8), P. 105319 - 105319

Published: May 19, 2025

Language: Английский

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The Impact of Traditional Chinese Medicine and Dietary Compounds on Modulating Gut Microbiota in Hepatic Fibrosis: A Review

Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38339 - e38339

Published: Sept. 26, 2024

Language: Английский

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Gut microbiome and liver diseases

Fundamental Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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