COVID and nervous system: Mechanisms and consequences

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 413 - 435

Published: Jan. 1, 2025

Language: Английский

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Advances in Virus Biorecognition and Detection Techniques for the Surveillance and Prevention of Infectious Diseases

Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 198 - 198

Published: March 20, 2025

Viral infectious diseases pose a serious threat to global public health due their high transmissibility, rapid mutation rates, and limited treatment options. Recent outbreaks of such as plague, monkeypox, avian influenza, coronavirus disease 2019 (COVID-19) have underscored the urgent need for efficient diagnostic surveillance technologies. Focusing on viral that seriously threaten human health, this review summarizes analyzes detection techniques from perspective combining prevention advice, discusses applications in improving sensitivity specificity. One major innovations is systematic integration advanced biorecognition technologies, bionanosensors, test strips, microfluidic platforms, along with exploration artificial intelligence virus detection. These technologies address limitations traditional methods enable real-time monitoring early warning outbreaks. By analyzing application these pathogens, new insights are provided development next-generation tools emerging re-emerging threats. In addition, we analyze current progress developed vaccines, vaccine research provide ideas future control development, call attention

Language: Английский

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Impact of COVID-19 Pandemic on Consumption of Anxiolytics, Antipsychotics, and Antidepressants in South Italian Region

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 652 - 652

Published: April 16, 2025

The COVID-19 lockdown had significant consequences on the mental health of millions people, leading to increasing prescription and use psychotropic drugs. Due lack data in current literature, this study aims estimate trends consumption anxiolytics, antipsychotics, antidepressants before during pandemic people South Italian region. We conducted a retrospective observational study, retrieving prescriptions dispensed pharmacies Basilicata region (South Italy) for period 2019–2021. presented data, expressed Daily Defined Doses (DDDs) 1000 persons/day (DHD), total resident population 95,021, dividing age groups into categories <30, 30–50, 50–70, >70 years. linear regression model examinate across Software XLSTAT was used statistical analysis. During period, more than 85,000 boxes medications were dispensed. research showed an increase sales all three drugs examined, with greater rise benzodiazepines (88.5%) selective serotonin reuptake inhibitors (81.9%) 2021 compared 2019, especially among women under 30 led drugs, confirming impact population’s health.

Language: Английский

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Gain-of-function and origin of Covid19

La Presse Médicale, Journal Year: 2023, Volume and Issue: 52(1), P. 104167 - 104167

Published: March 1, 2023

Language: Английский

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Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1425 - 1425

Published: June 23, 2023

Blood transfusion safety is an essential element of public health. Current blood screening strategies rely on targeted techniques that could miss unknown or unexpected pathogens. Recent studies have demonstrated the presence a viral community (virobiota/virome) in healthy individuals. Here, we characterized virome patients frequently exposed to by using Illumina metagenomic sequencing. The these was compared viruses present donors. A total number 155 beta-thalassemia, 149 hemodialysis, and 100 donors were pooled with five samples per pool. Members Anelloviridae Flaviviridae family most observed. Interestingly, harbored traces potentially pathogenic viruses, including adeno-, rota-, Merkel cell polyomavirus. Viruses abundant hemodialysis displayed higher anellovirus richness. Pegiviruses (Flaviviridae) only observed patient populations. An overall trend eukaryotic read abundance both groups This might be associated increased exposure through transfusion. Overall, findings this study various Iranian multiple-transfused

Language: Английский

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Covid-19 demography in France and South Africa: A comparative study of morbidity and mortality in 2020–2022

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0294870 - e0294870

Published: Feb. 5, 2024

Covid-19 epidemics raged around the world in years 2020-2022. The dynamics of and their mortality varied by country depending on prevention, treatments, vaccination health status population.

Language: Английский

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Global Inequities in COVID-19 Vaccination: Associated Factors and Tools to Measure Inequality

Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1245 - 1245

Published: July 16, 2023

Socioeconomic factors have been recognized by the WHO as determinants of health, and it is important to consider these in decision making curb existing inequality vaccination for SARS-CoV-2, which causes COVID-19.We aimed determine whether there a correlation between socioeconomic worldwide measure inequality.A study secondary sources was carried out assess against COVID-19 its association with factors. For this assessment, 169 countries were chosen from January 2020 March 2022 using LibreOffice JASP 0.16.1.10. Several mathematical models statistical tests used, including normality test, an analysis frequencies proportions, Kruskal-Wallis Spearman's correlations, Lorenz curve, Concentration Index, slope.Correlations found one, two, three doses. As GDP showed correlations 0.71 one dose 0.82 doses, we that greater competitiveness countries, higher percentage vaccinated individuals their populations. According regard receiving number reflected life expectancy indices 0.16-0.19 0.50. The continent highest degree Africa, lowest America. South Americans two doses at rate 6.19%/month, 4.3 times faster than Africans, 72% population being America, compared only 16% Africa.There associated

Language: Английский

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Genomic surveillance and serological profile of SARS-CoV-2 variants circulating in Macaé and nearby cities, southeastern Brazil

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 30, 2024

Introduction A characteristic of the COVID-19 pandemic has been sequential emergence and global dissemination SARS-CoV-2 variants, noted for their enhanced transmission efficiency. These variants with mutations in Spike glycoprotein (S-glycoprotein), which interacts ACE2 receptors human cells is critical infection, affects transmissibility virus, a matter great concern public health. Objective This research analyses effects these on cohort vaccinated naturally infected individuals from cities Macaé-RJ, Rio das Ostras-RJ, Campos dos Goytacazes-RJ, Brazil, March 2021 to 2023. Methods investigation encompasses Alpha (B.1.1.7), Gamma (P.1), Delta (B.1.617.2, B.1.671.3), Omicron (BQ.1, BQ.1.1 sublines, BF.7) focusing genomic surveillance implications disease’s epidemiology. The experimental analysis included control group (vaccinated uninfected subjects), an (post-vaccinated subjects). Samples nasopharyngeal swabs underwent viral detection via RT-qPCR diagnosis confirmation. RNase H-dependent (rhAmp-PCR) third-generation sequencing were used detect variants. Anti-S-glycoprotein immunoglobulins also evaluated noninfected volunteers. Symptoms compiled order reveal patterns clinical signs associated infection. Results study 289 participants, infections identified by ( n = 44), 189), 56) prevalent symptoms among participants cough, fever, sore throat, headache, runny nose. For Omicron, cognitive such as memory loss concentration issues reported. Interestingly, had higher anti-S-glycoprotein IgM production 28, 0.2833 ± 0.09768 OD) compared 14, 0.1035 0.03625 OD). Conversely, IgG was 12, 1.770 0.1393 than 26, 1.391 0.1563 Conclusion comprehensive enables monitoring predominant correlation cases, providing valuable insights Our continues survey circulating contributing understanding pandemic.

Language: Английский

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The dangerous biology of pathogenic germs

Comptes Rendus Biologies, Journal Year: 2024, Volume and Issue: 347(G1), P. 77 - 86

Published: Sept. 19, 2024

Language: Английский

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Vaccination increased host antiviral gene expression and reduced COVID-19 severity during the Omicron variant outbreak in Fuyang City, China

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 120, P. 110333 - 110333

Published: May 15, 2023

The differences in host antiviral gene expression and disease severity between vaccinated non-vaccinated coronavirus 2019 (COVID-19) patients are not well characterized. We sought to compare the clinical characteristics patterns of cohorts at Second People's Hospital Fuyang City. In this case-control study, we retrospectively analyzed 113 with a COVID-19 Omicron variant infection, 46 patients, 24 healthy subjects (no history COVID-19) recruited from Blood samples were collected each study participant for RNA extraction PCR. compared profiles controls who either or time infection. group, most asymptomatic, only 42.9 % developing fever. Notably, no had extrapulmonary organ damage. contrast, 21.4 group developed severe/critical (SC) 78.6 mild/moderate (MM) disease, fever occurring 74.2 patients. found that infection was associated significantly increased several important genes including IL12B, IL13, CXCL11, CXCL9, IFNA2, IFNA1, IFNγ, TNFα. Vaccinated infected mostly asymptomatic. frequently SC MM disease. Older also higher occurrence mild liver dysfunction. activation key thus may play role reducing severity.

Language: Английский

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