ABSTRACT
Flavonoid‐rich
plant
materials
have
gained
attention
for
their
potential
to
reduce
radiotherapy
side
effects.
Carica
papaya
(CP)
seeds,
known
high
flavonoid
content,
hold
promise
therapeutic
applications.
This
study
explored
the
extraction
and
evaluation
of
two
oils—sunflower
oil‐based
oil
(SPO)
pure
(PPO)—and
nano
emulsions
(SPOE
PPOE),
derived
from
CP
radioprotective
Chemical
analysis
using
QTOF‐MS
revealed
antioxidants
phytochemicals
in
oils
emulsions.
Size
zeta
measurements
dynamic
light
scattering
(DLS)
showed
particle
sizes
140
±
26.06
nm
PPOE
293.7
49.42
SPOE.
Post‐radiation,
both
SPOE
significantly
enhanced
cell
viability,
with
values
72.24
3.92
(
p
≤
0.001)
75.85
2.62
0.001),
respectively.
These
nanoemulsions
show
as
topical
agents
reducing
radiation‐induced
tissue
damage
radiotherapy.
Despite
promising
vitro
findings,
further
vivo
studies
are
needed
confirm
clinical
relevance
these
nanoemulsions.
Additionally,
incorporation
into
sunscreen
formulations
could
provide
protection
against
skin
damage,
broadening
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(5), P. 336 - 336
Published: Feb. 21, 2025
Iron-based
metal-organic
frameworks
(Fe-MOFs)
are
widely
used
for
agricultural
chemical
delivery
due
to
their
high
loading
capacity,
and
they
also
have
the
potential
provide
essential
iron
plant
growth.
Therefore,
hold
significant
promise
applications.
Evaluating
biotoxicity
of
Fe-MOFs
is
crucial
optimizing
use
in
agriculture.
In
this
study,
we
natural
biomacromolecule
carboxymethyl
cellulose
(CMC)
encapsulate
Fe-MOF
NH2-MIL-101
(Fe)
(MIL).
Through
hydroponic
experiments,
investigated
biotoxic
effects
on
rice
before
after
CMC
modification.
The
results
show
that
accumulation
dependent
dose
exposure
concentration
Fe-MOFs.
modification
(MIL@CMC)
can
reduce
release
rate
Fe
ions
from
aqueous
solutions
with
different
pH
values
(5
7).
Furthermore,
MIL@CMC
treatment
significantly
increases
absorption
by
both
aboveground
root
parts
rice.
alleviated
growth
inhibition
seedlings
increased
biomass
under
medium-
high-exposure
conditions.
Specifically,
roots,
MIL
induced
a
more
intense
oxidative
stress
response,
activities
related
antioxidant
enzymes
(CAT,
POD,
SOD)
MDA
content.
Our
demonstrated
encapsulation
NH2-MIL-101(Fe)
using
effectively
damage
promoted
uptake
These
findings
suggest
rational
positive
effect
reducing
phytotoxicity
MOFs
improving
biosafety
