Key metabolic pathways of the aging process of Citri Grandis Exocarpium and its identified potential metabolites associated with antioxidant activity DOI Creative Commons
Xiaoting Zhu, Jun Li,

Gengsheng Xiao

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 24, 2025

Citri Grandis Exocarpium (CGE), is renowned for its dual use in medicine and food, being well-known beneficial antioxidant anti-inflammatory effects. However, the changes of chemical composition activity CGE during storage (aging) process are still unclear. In this study, We examined metabolites samples aged 1 year (CG1), 3 years (CG3) 5 (CG5), mainly through comprehensive metabolomics techniques. The results indicated that analysis extracts by ultra-high-performance liquid chromatography-quadrupole/time flight mass spectrometry (UHPLC-QTOF-MS/MS) resulted detection 1249 metabolites. A total 57 differential were identified as potential markers distinguishing CGEs different aging chemometrics methods, including naringin, among others. KEGG annotation, enrichment topology revealed biosynthesis flavonoids was a key metabolic pathway CEG, involving 14 determined Total flavonoids, naringenin, butin, 7',4-dihydroxyflavone, phlorizin have been associated with activity. These clarified effects time on accumulation CGE, provided scientific basis understanding mechanism process.

Language: Английский

Key metabolic pathways of the aging process of Citri Grandis Exocarpium and its identified potential metabolites associated with antioxidant activity DOI Creative Commons
Xiaoting Zhu, Jun Li,

Gengsheng Xiao

et al.

npj Science of Food, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 24, 2025

Citri Grandis Exocarpium (CGE), is renowned for its dual use in medicine and food, being well-known beneficial antioxidant anti-inflammatory effects. However, the changes of chemical composition activity CGE during storage (aging) process are still unclear. In this study, We examined metabolites samples aged 1 year (CG1), 3 years (CG3) 5 (CG5), mainly through comprehensive metabolomics techniques. The results indicated that analysis extracts by ultra-high-performance liquid chromatography-quadrupole/time flight mass spectrometry (UHPLC-QTOF-MS/MS) resulted detection 1249 metabolites. A total 57 differential were identified as potential markers distinguishing CGEs different aging chemometrics methods, including naringin, among others. KEGG annotation, enrichment topology revealed biosynthesis flavonoids was a key metabolic pathway CEG, involving 14 determined Total flavonoids, naringenin, butin, 7',4-dihydroxyflavone, phlorizin have been associated with activity. These clarified effects time on accumulation CGE, provided scientific basis understanding mechanism process.

Language: Английский

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