Biomedical Chromatography,
Journal Year:
2023,
Volume and Issue:
38(3)
Published: Dec. 18, 2023
Abstract
The
cause
of
rheumatoid
arthritis
(RA)
is
unclear.
Xiaohuoluo
wan
(XHLW)
a
classical
Chinese
medicine
that
particularly
effective
in
the
treatment
RA.
Given
chemical
composition
XHLW
at
overall
level
has
been
little
studied
and
molecular
mechanism
for
RA
not
clear,
we
searched
potential
active
compounds
explored
their
anti‐inflammatory
by
flexibly
integrating
high‐resolution
ultra‐performance
liquid
chromatography–mass
spectrometry
(UPLC–MS)‐based
vitro
vivo
chemomics,
network
pharmacology,
other
means.
results
study
identified
XHLW,
such
as
alkaloids,
nucleosides,
fatty
acids,
may
play
an
role
regulating
key
targets
IL‐2,
STAT1,
JAK3,
MAPK8,
inducing
immune
response
through
IL‐17
signaling
pathway,
T‐cell
receptor,
FoxO,
tumor
necrosis
factor
(TNF),
so
forth,
inhibiting
release
inflammatory
factors
resisting
oxidative
stress
pathways
to
treat
this
provide
referable
data
screening
exploration
mechanisms
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(12), P. 606 - 606
Published: Nov. 24, 2023
A
total
of
16
novel
carboxymethyl
chitosan
derivatives
bearing
quinoline
groups
in
four
classes
were
prepared
by
different
synthetic
methods.
Their
chemical
structures
confirmed
Fourier-transform
infrared
spectroscopy
(FTIR),
nuclear
magnetic
resonance
(NMR),
and
elemental
analysis.
The
antioxidant
experiment
results
vitro
(including
DPPH
radical
scavenging
ability,
superoxide
anion
hydroxyl
ferric
reducing
power)
demonstrated
that
adding
to
(CS)
(CMCS)
enhanced
the
ability
CS
CMCS.
Among
them,
both
N,
O-CMCS
N-TM-O-CMCS
showed
over
70%.
In
addition,
their
radicals
reached
more
than
90%
at
maximum
tested
concentration
1.6
mg/mL.
Moreover,
cytotoxicity
assay
was
carried
out
on
L929
cells
MTT
method,
indicated
all
no
(cell
viability
>
75%)
except
derivative
1a,
which
low
1000
μg/mL
50.77
±
4.67%).
conclusion,
remarkable
weak
cytotoxicity,
highlighting
potential
use
food
medical
applications.
Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 11, 2025
Background
Peak
width
of
skeletonized
mean
diffusivity
(PSMD)
is
a
novel
marker
small
vessel
disease.
This
study
aimed
to
investigate
the
presence
disease
in
patients
with
occipital
lobe
epilepsy
(OLE)
using
PSMD.
Methods
We
enrolled
27
newly
diagnosed
OLE
and
included
29
healthy
controls.
The
age
sex
controls
were
comparable.
Diffusion
tensor
imaging
(DTI)
was
performed
3
T
MRI
scanner.
measured
PSMD
based
on
DTI
several
steps,
including
preprocessing,
skeletonization,
application
custom
mask,
histogram
analysis,
FSL
program.
compared
between
Additionally,
we
correlation
analysis
clinical
factors
OLE.
Results
Our
findings
revealed
that
exhibited
higher
(2.459
vs.
2.079
×
10
−4
mm
2
/s,
p
<
0.001).
In
addition,
positively
correlated
(
r
=
0.412,
0.032).
However,
not
associated
other
such
as
at
seizure
onset
duration
epilepsy.
Conclusion
demonstrated
had
than
controls,
indicating
evidence
finding
also
highlights
potential
for
detecting
diseases
epileptic
disorders.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1634 - 1634
Published: Feb. 14, 2025
Aging
and
age-related
neurodegenerative
disorders
are
characterized
by
the
dysfunction
or
loss
of
brain
nicotinic
acetylcholine
receptors
(nAChRs),
these
changes
may
be
related
to
other
senescence
markers,
such
as
oxidative
stress
DNA
repair
dysfunction.
However,
mechanism
nAChR
in
aging
modification
this
process
drugs
(e.g.,
memantine,
Mem)
not
yet
fully
understood.
To
study
whether
differences
expression
rat
occur
due
modulated
Mem,
we
analyzed
subunits
(at
RNA
protein
levels)
biomarkers
real-time
quantitative
polymerase
chain
reaction
(RQ-PCR)
Western
blot
validation.
Twenty-one
female
Wistar
rats
were
divided
into
four
groups,
depending
on
age,
oldest
group
received
injections
Mem
water
with
use
intragastric
catheters.
We
studied
cerebral
grey
matter
(CGM),
subcortical
white
(SCWM),
cerebellum
(Ce).
Results
showed
an
decrease
α7
mRNA
level
SCWM.
The
was
accompanied
reduced
8-oxoguanine
glycosylase
1
(OGG1)
increased
tumor
necrosis
factor
alpha
(TNFα)
level.
In
group,
observed
a
higher
SCWM
Ce.
Biomarker
levels
changed,
but
different
extent
area.
Importantly,
antioxidative
status
stopped
even
regressed
under
treatment.
After
two
weeks
treatment,
increase
TP53
8-oxo-2'deoxyguanosine
(8-oxo-2'dG)
observed.
conclude
that
administration
protective
against
mechanisms.
IBRO Neuroscience Reports,
Journal Year:
2025,
Volume and Issue:
18, P. 453 - 463
Published: March 1, 2025
The
over-stimulation
of
N-methyl-d-aspartate
glutamate
receptors
causes
an
excitotoxic
neuronal
death
which
plays
important
role
in
many
neurodegenerative
diseases.
Carissa
edulis,
a
medicinal
plant
used
African
pharmacopeia
has
been
shown
to
have
therapeutic
effects.
In
this
study,
the
effects
edulis
aqueous
extract
on
L-glutamic
acid-induced
neurotoxicity
mice
were
investigated.
Two-month-old
received
intraperitoneal
injection
acid
(2
g/kg)
for
seven
consecutive
days
and
treated
with
edulis.
Mice
monitored
behavioural
studies
including
locomotion,
muscle
strength,
memory.
Oxidative
stress
was
determined
by
measuring
lipid
peroxidation
level
antioxidant
enzymes.
Elisa
kits
evaluate
levels
proinflammatory
cytokines.
Hippocampal
histopathology
examined
using
cresyl
violet
staining.
administration
exhibited
protective
effect
abnormal
locomotor
activity
increased
mice's
strength.
Also,
it
memory
mice.
decreased
malondialdehyde
catalase
glutathione
level.
Furthermore,
significantly
IL-1β
TNF-α
compared
group.
There
no
significant
pathological
changes
hippocampus
edulis-treated
group
Our
results
indicated
that
showed
alleviating
impairment,
decreasing
oxidative
stress,
cytokines
brains
acid.
Therefore,
treatment
may
help
reduce
glutamatergic
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107097 - 107097
Published: April 1, 2025
Quinolines
have
been
an
interest
of
study
for
a
few
decades
due
to
the
importance
this
system
in
natural
and
pharmaceutical
products.
Since
their
discovery
nineteenth
century,
many
medicinal
properties
found
quinoline
compounds.
Firstly,
as
anti-parasitic
agent
against
malaria
then
other
diseases,
such
as,
parasitic
infections,
HIV,
bacterial
infections
cancer.
Consequently,
synthetic
methods
developed
afford
ring.
In
review
we
look
back
at
traditional
forward
most
recent
promising
"green"
synthesis
quinolines.
Also,
newest
advances
therapeutic
compounds
based
on
skeleton
treatment
cancer
diseases
applications
derivatives
drug
delivery
systems.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(8), P. 2798 - 2798
Published: April 18, 2025
Delirium
is
a
frequent
complication
in
critically
ill
patients,
often
leading
to
worse
clinical
outcomes,
prolonged
ICU
stays,
and
an
increased
healthcare
burden.
Its
identification
has
become
more
consistent
with
the
adoption
of
validated
diagnostic
tools,
allowing
clinicians
recognize
address
this
condition
effectively.
Although
delirium
can
arise
from
direct
neurological
dysfunction,
it
frequently
consequence
systemic
conditions
such
as
sepsis
or
organ
failure.
Therefore,
comprehensive
evaluation
underlying
causes
essential
before
initiating
pharmacological
treatment.
Among
options,
quetiapine
gained
attention
for
its
use
patients
delirium.
Compared
first-generation
antipsychotics,
preferred
due
sedative
effects
favorable
safety.
However,
current
guidelines
remain
inconclusive
regarding
routine
use,
evidence
supporting
efficacy
limited.
One
main
challenges
heterogeneity
patient
populations
included
randomized
trials,
making
difficult
determine
whether
specific
subgroups
may
benefit
This
narrative
review
explores
properties
quetiapine,
potential
role
managing
delirium,
state
safety
effectiveness.
